Laxers powder for preparation of solution for injection 1g + 1g vial No. 1

Laxers is an antibacterial agent for systemic use. It is a third-generation cephalosporin.

The drug Laxers is used to treat infections caused by sensitive strains of microorganisms:

Warehouse

Contraindication

Contraindicated in patients with hypersensitivity to the active substances (sulbactam, cefoperazone), beta-lactam antibiotics or any excipients.

Method of application

Adults

The usual adult dose is 2–4 g/day (i.e. 1 to 2 g of cefoperazone/day) administered intravenously or intramuscularly in equally divided doses every 12 hours.

Use in children

The usual dose of the drug for children is 40 to 80 mg/kg body weight/day (i.e. 20–40 mg cefoperazone/kg body weight/day), evenly divided into 2–4 doses.

Application features

Before initiating therapy with sulbactam/cefoperazone, careful inquiry should be made regarding previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs. Antibiotics should be prescribed with caution in patients with a history of any allergy, especially to drugs.

If allergic reactions occur, the drug should be discontinued and appropriate treatment should be initiated. Severe anaphylactic reactions require immediate administration of epinephrine. If necessary, oxygen therapy, intravenous steroids, and airway patency, including intubation, should be administered.

Pregnant women

The drug can be used during pregnancy only if there are clear indications.

Children

The medicine is used for children

Drivers

The effect of the drug on the ability to drive or operate other mechanisms is unlikely.

Overdose

Information on the acute toxicity of cefoperazone sodium and sulbactam sodium in humans is limited. Overdosage is expected to produce effects that are primarily an increase in the adverse effects reported with the drug. It should be noted that high concentrations of beta-lactam antibiotics in the cerebrospinal fluid may cause neurological reactions, including convulsions. Since cefoperazone and sulbactam are removed from the circulation by hemodialysis, this procedure may enhance the elimination of the drug in patients with renal impairment in case of overdose.

Side effects

From the blood and lymphatic system: neutropenia, leukopenia, direct positive Coombs test, decreased hemoglobin level, decreased hematocrit level, thrombocytopenia.

Immune system disorders: anaphylactic shock, anaphylactic reaction, anaphylactoid reaction including shock, hypersensitivity.

From the nervous system: headache.

Vascular disorders: haemorrhage (including fatal outcome), vasculitis, hypotension

Storage conditions

Store in the original packaging at a temperature not exceeding 25 °C.