Levofloxacin film-coated tablets 250 mg No. 10

Levofloxacin tablets are indicated for the treatment of infections caused by levofloxacin-sensitive microorganisms:

Composition

Active ingredient: 1 tablet contains 256.23 mg of levofloxacin hemihydrate, which is equivalent to 250 mg of levofloxacin;

1 tablet contains 512.46 mg of levofloxacin hemihydrate, which is equivalent to 500 mg of levofloxacin;

Excipients: hypromellose, crospovidone, microcrystalline cellulose, sodium stearyl fumarate, polyethylene glycol 6000, talc, red iron oxide (E172), yellow iron oxide (E172), titanium dioxide (E171).

Contraindication

Method of application

The drug is intended for oral use. The tablets should be swallowed without chewing, with sufficient liquid. The drug can be taken regardless of meals.

The drug should be used at least 2 hours before or after the use of iron salts, zinc salts, antacids containing magnesium or aluminum, didanosine (only for forms containing aluminum or magnesium in buffering agents) and sucralfate.

Application features

Pregnant women

Contraindicated.

Children

Contraindicated.

Drivers

With caution.

Overdose

Symptoms: central nervous system disorders (confusion, dizziness, impaired consciousness and seizures, hallucinations and tremors), digestive system disorders (nausea and erosion of mucous membranes), possible prolongation of the QT interval.

Treatment: symptomatic therapy. ECG monitoring should be carried out, as QT interval prolongation is possible. Antacids are used to protect the gastric mucosa. Hemodialysis, including peritoneal dialysis or HAPD, is not effective in removing levofloxacin from the body. There is no specific antidote.

Side effects

On the part of the psyche: often (from> 1/100 to <1/10) - insomnia.

From the nervous system: often (from> 1/100 to <1/10) - headache, dizziness.

Gastrointestinal: often (from > 1/100 to <1/10) - diarrhea, nausea, vomiting.

On the part of the liver: sometimes (from> 1/100 to <1/10) - increased activity of liver enzymes (ALT / AST, alkaline phosphatase, GGTP).

Interaction

Clinical pharmacology studies have demonstrated that no clinically significant effect on the pharmacokinetics of levofloxacin was caused when levofloxacin was used together with the following drugs: calcium carbonate, digoxin, glibenclamide, ranitidine.

Storage conditions

Store at a temperature not exceeding 30 °C.

Keep out of reach of children.

Shelf life - 3 years.