Instructions Levomekol ointment 40 g
Composition
active ingredients: chloramphenicol (chloramphenicol), methyluracil;
1 g of ointment contains chloramphenicol (chloramphenicol) 7.5 mg, methyluracil 40 mg;
excipients: polyethylene glycol 400, polyethylene glycol 1500.
Dosage form
Ointment.
Main physicochemical properties: white or white with a yellowish tinge of color ointment.
Pharmacotherapeutic group
Drugs that promote wound healing (scarring). ATX code D03A X.
Pharmacological properties
Pharmacodynamics.
Combined drug for topical use with antimicrobial, reparative and anti-inflammatory effects. Chloramphenicol (chloramphenicol), which is part of the drug, has an antimicrobial effect, the mechanism of which is associated with a violation of the synthesis of proteins of microorganisms. It acts bacteriostatically, active against gram-positive and gram-negative microorganisms (staphylococcus, streptococcus, Pseudomonas aeruginosa and Escherichia coli). Methyluracil accelerates the processes of cell regeneration, promotes wound healing and has an anti-inflammatory effect.
Pharmacokinetics.
The polyethylene oxide base adsorbs wound exudate, potentiates the activity of medicinal substances. The drug easily penetrates into tissues without damaging biological membranes, however, the degree of systemic absorption after application of the drug to the skin, wounds and mucous membranes is unknown.
Indication
Treatment of purulent wounds (infected with mixed microbial flora) in the first phase of the wound process, trophic ulcers, pressure sores, infected burns, boils, carbuncles.
Contraindication
Hypersensitivity to the components of the drug; psoriasis, eczema, fungal skin lesions.
Interaction with other medicinal products and other types of interactions
It is undesirable to use simultaneously with drugs that inhibit hematopoiesis: sulfonamides, cytostatics, pyrazoline derivatives; with diphenyl, barbiturates, ethanol.
Simultaneous use of the drug with erythromycin, oleandomycin, nystatin and levorin increases the antibacterial activity of the ointment, and with benzylpenicillin salts it decreases it.
Application features
The use of antibacterial agents for external use may lead to skin sensitization, which is accompanied by the development of hypersensitivity reactions with further use of this drug externally or in the form of a dosage form for systemic action.
In the presence of pus or necrotic masses, the antibacterial effect of the drug is maintained. Do not allow the ointment to get on the mucous membrane of the eyes.
With prolonged (longer than 1 month) use of the drug, it is necessary to monitor the state of the peripheral blood picture.
You should not violate the rules for using the medicine.
Use during pregnancy or breastfeeding
The use of the drug during pregnancy or breastfeeding is justified only if the intended benefit to the mother outweighs the potential risk to the fetus or child.
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Method of administration and doses
Levomekol is intended for external use in adults and children over 3 years of age. Sterile gauze napkins are impregnated with the ointment, which should be used to fill the wound. It is possible to introduce the ointment into purulent cavities through a catheter (drainage tube) using a syringe. In such cases, Levomekol is pre-heated to 35-36 ° C. Dressings should be carried out daily until the wounds are completely cleansed of purulent-necrotic masses and until their granulation begins. With a large area of wound surfaces, the daily dose of the ointment in terms of chloramphenicol (chloramphenicol) should not exceed 3 g.
The ointment should be used from the first day of injury for 4 days. Hyperosmolar ointment Levomekol is not recommended for long-term use, as it can cause osmotic shock in intact cells. On the 5th-7th day of treatment, it is recommended to change the ointment to drugs that restore the integrity of damaged tissue.
Children.
The drug should be used in children over 3 years of age.
Overdose
Prolonged (more than 5-7 days) external use often leads to contact sensitization, which is accompanied by the development of hypersensitivity reactions upon subsequent use of the drug externally or in the form of dosage forms for systemic use. Therapy is symptomatic.
Side effects
Allergic reactions are possible, including skin rashes, dermatitis, burning sensation, itching, local edema, hyperemia, angioedema, urticaria; general weakness is possible. In such cases, the use of the ointment should be discontinued and a doctor should be consulted.
Expiration date
2 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C, do not freeze. Keep out of the reach of children.
Packaging
25 g in containers. 20 g or 30 g or 40 g in aluminum or laminate tubes in a pack or without a pack.
Vacation category
Without a prescription.
Producer
PrJSC Pharmaceutical Factory "Viola".
Address
Ukraine, 69063, Zaporizhia, Academician Amosov St., 75.
Applicant
PrJSC Pharmaceutical Factory "Viola".
