Instructions Liasten powder for solution for injection 0.002 g bottle No. 5
Composition
active ingredient: glucosaminylmuramylpentapeptide (N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-L-asparagyl);
1 vial contains 0.002 g of glucosaminylmuramyl pentapeptide (N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-L-asparagyl) in terms of peptides;
excipient: dextran 40.
Dosage form
Powder for preparation of solution for injection.
Main physicochemical properties: lyophilized powder or porous mass of white or white with a yellowish tinge, easily soluble in water for injection and 0.9% sodium chloride solution for injection.
Pharmacotherapeutic group
Immunostimulants. ATX code L03A.
Pharmacological properties
LIASTEN® belongs to immunomodulators of natural origin with a wide spectrum of action. It is a fragment of the cell wall of lactobacteria. LIASTEN® stimulates the function of macrophages and normalizes the number of T-lymphocytes. LIASTEN® activates cells of the monocyte-macrophage series, phagocytosis, increases the activity of lysosomal enzymes, the production of reactive oxygen species, enhances the cytotoxic effect of macrophages on cells infected with viruses, bacteria and tumor cells. The drug enhances the synthesis of cytokines, in particular interleukin-1. LIASTEN® increases the cytotoxic activity of natural killer cells. The immunomodulatory activity of LIASTEN® is also manifested in the fact that the drug preserves the endocrine function of the thymus, helps reduce the level of circulating immune complexes. LIASTEN® helps stimulate leukopoiesis, has weak antimetastatic and antitumor effects, and reduces the side effects of chemo- and radiation therapy. The drug does not have embryotoxic, mutagenic and teratogenic effects.
Indication
LIASTEN® is prescribed as an immunomodulatory agent for various diseases accompanied by secondary immunodeficiency, leukopenia, in particular during chemo- and radiation therapy of cancer patients and patients with leukemia in order to reduce the toxic effect of cytostatics; in acute and chronic radiation injuries; in surgical treatment of cancer and other categories of patients. LIASTEN® is indicated for acute and chronic bacterial and viral infections, in particular tuberculosis, as well as for the treatment of patients with leukopenia of various origins.
Contraindication
Hypersensitivity to the components of the drug and autoimmune diseases. Children's age, pregnancy, breastfeeding.
Interaction with other medicinal products and other types of interactions
Unknown.
Application features
It is prescribed with caution to patients with allergic and autoimmune diseases.
Ability to influence reaction speed when driving vehicles or other mechanisms
No effect.
Use during pregnancy or breastfeeding
There is no experience with the use of the drug in pregnant and breastfeeding women.
Method of administration and doses
LIASTEN® is administered subcutaneously or intramuscularly. Before using the drug, 1–2 ml of 0.9% isotonic sodium chloride solution for injection or water for injection is added to the vial.
If subcutaneous administration of the drug is planned, 1 ml of solvent can be used. After adding the solvent, the bottle is shaken thoroughly until its contents are completely dissolved. The usual daily dose of the drug for adults is 0.002 g of the active substance. The course of treatment involves 3–5 injections with an interval of 5–7 days. If necessary, repeated courses of treatment can be carried out after 3–6 and 12 months.
Children
There is no experience with the use of the drug in children.
Overdose
No cases of overdose with Liasten have been identified.
Adverse reactions
Sometimes a short-term slight increase in body temperature, local reactions, and joint pain are possible. In such cases, it is necessary to increase the interval between injections of the drug to 10 days.
Expiration date
3 years.
Storage conditions
Store at a temperature not exceeding 25 ° C. Store the drug solution for no more than 24 hours in the refrigerator at a temperature of + 4 to + 6 ° C.
Packaging
5 bottles in a cardboard box.
Vacation category
According to the recipe.
Producer
SE "Enzym".
Location of the manufacturer and its business address
Ukraine, 24321, Vinnytsia region, Ladyzhyn city, Khlibozavodska st., 2.
