Instructions for Livolin forte capsules blister No. 30
Composition
active ingredients:
1 capsule contains lecithin 35% (polyunsaturated phosphatidylcholine) 300 mg, dl-α-tocopheryl acetate (vitamin E) 10 mg, thiamine mononitrate (vitamin B1) 10 mg, riboflavin (vitamin B2) 6 mg, pyridoxine hydrochloride (vitamin B6) 10 mg, cyanocobalamin (vitamin B12) 10 μg, nicotinamide 30 mg;
excipients: soybean oil, hydrogenated vegetable oil, white wax;
capsule shell: gelatin, glycerin, titanium dioxide (E 171), red iron oxide (E 172), black iron oxide (E 172), yellow iron oxide (E 172), purified water.
Dosage form
Capsules.
Main physicochemical properties: oblong, brown, opaque soft gelatin capsules containing an oily mass of yellow-brown color.
Pharmacotherapeutic group
Drugs used in liver diseases, lipotropic substances. ATC code A05B A.
Pharmacological properties
Pharmacodynamics
The active ingredient of Livolin Forte is lecithin 35%, which contains phospholipids.
Phospholipids, which are part of the drug, are similar in chemical structure to endogenous phospholipids, but they are superior to them due to the high content of polyunsaturated fatty acids. These molecules are mainly incorporated into the structures of cell membranes and facilitate the restoration of damaged liver tissues. Phospholipids have a hepatoprotective effect when liver cells are damaged by viruses, alcohol, toxic substances. The rate of entry and excretion of substances in the cells increases, the restoration of enzyme systems and improvement of liver metabolism are ensured.
Phospholipids affect impaired fat metabolism by regulating lipoprotein metabolism, as a result of which neutral fats and cholesterol are converted into forms suitable for transport, especially by increasing the ability of high-density lipoproteins (HDL) to bind cholesterol, and are directed for further oxidation. During the excretion of phospholipids through the biliary tract, the lithogenic index decreases and bile is stabilized.
The vitamin complex performs the following functions: nicotinamide exhibits a hypolipidemic effect and prevents fatty degeneration of the liver; pyridoxine as a coenzyme participates in the metabolism of phospholipids, amino acids and proteins; thiamine participates in carbohydrate metabolism; riboflavin is a cofactor of numerous respiratory enzymes; tocopheryl acts as an antioxidant at the cell membrane level, preventing the oxidation of unsaturated fatty acids.
When taken orally, more than 90% of the drug is absorbed in the small intestine. The main amount is broken down by phospholipase-A to 1-acyl-lyso-phosphatidylcholine, 50% of which is immediately broken down into polyunsaturated phosphatidylcholine during absorption in the small intestine. Polyunsaturated phosphatidylcholine enters the blood through the lymphatic system and is then transported to the liver, mainly in a complex with high-density lipoproteins. The maximum content of phosphatidylcholine in the blood 6-24 hours after oral administration is on average 20%.
Pharmacokinetics
Not studied.
Indication
Fatty liver degeneration (including liver damage in diabetes), acute and chronic hepatitis, cirrhosis of the liver, pre- and postoperative treatment of the patient during surgical intervention on the liver and biliary tract, toxic liver damage, toxicosis of pregnancy, radiation syndrome.
Contraindication
Hypersensitivity to any component of the drug, soy, peanuts or peanut oil. Allergic diseases. Intrahepatic cholestasis. Gastric and duodenal ulcer in the acute stage. Unipolar and clinical depression.
Interaction with other medicinal products and other types of interactions
Vitamin B6 weakens the effect of levodopa, prevents or reduces toxic manifestations observed with the use of isoniazid and other anti-tuberculosis drugs.
PASK, cimetidine, calcium preparations, ethanol reduce the absorption of vitamin B12.
Riboflavin is incompatible with streptomycin and reduces the effectiveness of antibacterial drugs (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin). Tricyclic antidepressants, imiprimine and amitriptyline, inhibit riboflavin metabolism, especially in cardiac tissues.
It is not recommended to use it together with other multivitamin preparations, as an overdose of the latter in the body is possible.
Vitamin E cannot be used together with iron preparations, silver, alkaline agents (sodium bicarbonate, trisamine), indirect anticoagulants (dicoumarin, neodicoumarin, etc.).
Vitamin E enhances the effect of steroidal and nonsteroidal anti-inflammatory drugs (diclofenac sodium, ibuprofen, prednisolone, etc.); reduces the toxic effect of cardiac glycosides (digitoxin, digoxin), vitamins A and D. The appointment of vitamin E in high doses can cause vitamin A deficiency in the body.
Increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have elevated levels of lipid peroxidation products in the blood). Cholestyramine, colestipol, mineral oils reduce the absorption of vitamin E.
Application features
Use the drug with caution and after consulting a doctor in severe heart or kidney diseases, increased risk of thromboembolism, patients with a history of gastric and duodenal ulcers, neoplasms, nephrolithiasis, erythremia, erythrocytosis, hyperuricemia.
The use of the drug may lead to a false-positive test for urobilinogen using Ehrlich's reagent.
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Use during pregnancy or breastfeeding
The drug can be used during pregnancy or breastfeeding as directed by a doctor and under his supervision.
Method of administration and doses
The dose of the drug for adults and children over 12 years of age is usually 1 capsule 3 times a day. Take the capsules during meals, without chewing and with a small amount of water.
The dosage of the drug and the duration of treatment are determined by the doctor individually for each patient, taking into account the nature and severity of the pathological process, the characteristics of the course of the disease, the achieved therapeutic effect and the tolerability of the drug. On average, the course of treatment is at least 3 months.
Children
Contraindicated for children under 12 years of age.
Overdose
Symptoms: nausea, vomiting, diarrhea, headache, drowsiness, lethargy, facial flushing, irritability, increased manifestations of adverse reactions. With prolonged use in high doses, peripheral neuropathy is possible.
Treatment: gastric lavage, use of activated charcoal, hyperosmotic laxatives.
In case of an overdose of Vitamin B1: anorexia, headache, insomnia, irritability, nausea, nervousness, rapid heartbeat, tremors and vomiting.
In case of Vitamin B6 overdose: symptoms include ataxia and sensory neuropathy from doses of 50 mg to 2 g per day for prolonged periods of time. Doses of 70-357 mg/kg are well tolerated.
Nicotinamide overdose: symptoms include gastrointestinal upset. Treatment is supportive.
Adverse reactions
In some cases, the following side effects may occur when using the drug.
On the part of the digestive tract: dyspeptic disorders, nausea, vomiting, diarrhea, constipation, heartburn, discomfort and pain in the epigastrium, decreased appetite.
Skin and subcutaneous tissue disorders: skin rash, urticaria, itching.
In individuals with individual intolerance to any component of the drug, hypersensitivity reactions, including angioedema and anaphylaxis, are possible.
Urine may turn yellow.
Expiration date
2 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
10 capsules in a blister, 3 blisters in an individual package and in a cardboard box.
Vacation category
Without a prescription.
Producer
Mega Lifesciences Public Company Limited.
Location of the manufacturer and its business address
Factory 1 384, Moo 4, Soi 6, Bangpu Industrial Estate, Pattana 3 Road, Phraeksa, Mueang 10280 Samut Prakan Thailand.
