Loperamide-Health tablets are indicated for:
Symptomatic treatment of acute diarrhea in adults and children over 12 years of age. Symptomatic treatment of acute episodes of diarrhea caused by irritable bowel syndrome in adults aged 18 years and older after initial diagnosis by a physician.
Composition
Active ingredient: loperamide;
1 tablet contains loperamide hydrochloride 2 mg;
Excipients: lactose, potato starch, magnesium stearate.
Contraindication
Loperamide is contraindicated:
patients with known hypersensitivity to loperamide hydrochloride or to any of the components of the drug; children under 12 years of age; patients with acute dysentery, characterized by the presence of blood in the stool and elevated body temperature; patients with acute ulcerative colitis or pseudomembranous colitis associated with the use of broad-spectrum antibiotics; patients with bacterial enterocolitis caused by microorganisms of the Salmonella, Shigella and Campylobacter families.
Loperamide should not be used at all if it is necessary to avoid inhibition of peristalsis due to the possible risk of significant complications, including intestinal obstruction, megacolon, and toxic megacolon.
The drug should be discontinued immediately if constipation, bloating, or intestinal obstruction develops.
Method of application
Loperamide is not indicated for the initial treatment of severe diarrhoea with associated fluid and electrolyte depletion. In children in particular, it is advisable to replace this loss by parenteral or oral replacement therapy.
The tablets should be taken without chewing, with water.
Symptomatic treatment of acute diarrhea in adults and children over 12 years of age
The initial dose is 2 tablets (4 mg), then 1 tablet (2 mg) after each subsequent loose stool. The usual dose is 3-4 tablets (6-8 mg) per day. The maximum daily dose for acute diarrhea should not exceed 6 tablets (12 mg).
Application features
Pregnant women
Not recommended for use.
Children
The drug should be used in children from 12 years of age for the symptomatic treatment of acute diarrhea.
Drivers
Increased fatigue, dizziness or drowsiness may occur in diarrhea syndrome when using loperamide hydrochloride. Therefore, it is recommended to take this drug with caution when driving a car or operating machinery.
Overdose
Symptoms: In case of overdose (including relative overdose due to impaired liver function), central nervous system depression (stupor, impaired coordination, drowsiness, miosis, muscle hypertonia, respiratory depression), urinary retention and a complex of symptoms similar to intestinal obstruction may occur.
Children may be more sensitive to effects on the central nervous system.
Treatment. In case of overdose, the patient should immediately consult a doctor. If symptoms of overdose appear, naloxone can be used as an antidote. Since the duration of action of loperamide is longer than that of naloxone (1-3 hours), repeated administration of naloxone may be necessary. The patient should be closely monitored for at least 48 hours to detect possible central nervous system depression.
Side effects
Adults and children 12 years of age and older. Adverse reactions in patients with acute diarrhea, occurring at a frequency of 1% or more, reported in safety studies with loperamide hydrochloride:
Nervous system: headache. Gastrointestinal tract: constipation, bloating, nausea.
Side effects that occurred with a frequency of less than 1% in safety studies of loperamide hydrochloride:
Nervous system: dizziness. Gastrointestinal tract: dry mouth, flatulence, abdominal pain and discomfort, vomiting, upper abdominal pain, dyspepsia. Skin and subcutaneous tissue: rash.
Interaction
There are reports of interactions between loperamide and drugs with similar pharmacological properties. Drugs that have a central nervous system depressant effect should not be used concomitantly with loperamide in children.
Concomitant treatment with oral desmopressin resulted in a 3-fold increase in plasma desmopressin concentrations, probably due to slower gastrointestinal motility.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Shelf life - 4 years.
