Magnesium sulfate electrolyte solution is indicated for use in:
hypertensive crisis, ventricular arrhythmias, convulsive syndrome; eclampsia, hypomagnesemia, increased need for magnesium; use in complex therapy of premature birth, angina pectoris, poisoning with heavy metal salts, tetraethyl lead, soluble barium salts (antidote).
Composition
1 ml of solution contains 250 mg of magnesium sulfate heptahydrate;
excipient: sodium hydroxide, diluted hydrochloric acid, water for injections.
Contraindication
Increased individual sensitivity to the components of the drug, arterial hypotension, severe bradycardia, atrioventricular block, conditions caused by calcium deficiency and depression of the respiratory center, cachexia, impaired renal function, severe hepatic or renal failure, myasthenia gravis, malignant neoplasms.
Method of application
Arterial hypertension.
Administer 5–10–20 ml intramuscularly daily.
The course of treatment is 15–20 injections, and along with a decrease in blood pressure, the severity of angina may decrease.
Hypertensive crisis.
Administer 10–20 ml intramuscularly or intravenously slowly.
Cardiac arrhythmias.
Administer 4–8 ml intravenously over 5–10 minutes, repeat injection if necessary.
Ischemic stroke.
10–20 ml intravenously for 5–7 days.
Convulsive syndrome.
Adults should be given 5–10–20 ml intramuscularly. Children should be given intramuscularly at the rate of 0.08–0.16 ml/kg body weight (20–40 mg/kg).
Toxicosis of pregnant women.
10–20 ml 1–2 times a day intramuscularly.
Labor pain relief.
5–10–20 ml intramuscularly, if necessary, combine magnesium sulfate with analgesics.
Urinary retention.
Administer 5–10 ml of the drug intramuscularly or 5–10 ml of a 25% magnesium sulfate solution diluted 5 times intravenously (also administered as an enema).
As an antidote.
In case of intoxication with mercury, arsenic, tetraethyl lead, intravenously administer 5–10 ml of a 25% solution of magnesium sulfate diluted 2.5–5 times. In case of poisoning with soluble barium salts, administer 4–8 ml intravenously or wash the stomach with a 1% solution of magnesium sulfate.
Newborns.
In case of intracranial hypertension and severe asphyxia in newborns, administer intramuscularly, starting with a dose of 0.2 ml/kg of body weight per day, increasing the dose on the 3rd–4th day to 0.8 ml/kg of body weight per day for 3–8 days in complex therapy. To eliminate magnesium deficiency in newborns, prescribe 0.5–0.8 ml/kg 1 time per day for 5–8 days.
Application features
Pregnant women
During pregnancy, magnesium sulfate should be used with extreme caution, only in cases where the expected therapeutic effect outweighs the potential risk to the fetus.
If necessary, use of the drug should stop breastfeeding.
Children
The drug can be used in pediatric practice.
Drivers
Patients should be warned about the need to be careful when working with potentially dangerous mechanisms or when driving vehicles, since the drug has a sedative effect.
Overdose
Symptoms: signs of hypermagnesemia in order of increasing serum magnesium concentration:
decreased deep tendon reflexes (2–3.5 mmol/l); prolonged PQ interval and widened QRS complex on ECG (2.5–5 mmol/l); loss of deep tendon reflexes (4–5 mmol/l); depression of the respiratory center (5–6.5 mmol/l); impaired cardiac conduction (7.5 mmol/l); cardiac arrest (12.5 mmol/l).
In addition, hyperhidrosis, anxiety, inhibition, polyuria, uterine atony.
Treatment: calcium preparations are the specific antidote.
Side effects
Cardiovascular system: bradycardia, palpitations.
Respiratory system: shortness of breath, respiratory depression.
From the nervous system: headache, dizziness, general weakness.
Musculoskeletal system: muscle weakness.
From the digestive tract: nausea, vomiting.
Allergic reactions: anaphylactic shock, angioedema, hyperthermic syndrome, chills.
Injection site disorders: hyperemia, edema, pain.
Storage conditions
Store at a temperature not exceeding 25 ºС in the original packaging. Do not freeze. Keep out of the reach of children.
Shelf life - 2 years.
