Marcaine solution for injection 5 mg/ml bottle 20 ml No. 5

Marcaine, 0.5% solution, is used for local anesthesia by percutaneous infiltration, peripheral nerve block(s) and central nerve block (caudal or epidural), i.e., by a specialist in situations where prolonged anesthesia is required. Since sensory nerve block is more pronounced than motor block, Marcaine is particularly effective in relieving pain, for example, during childbirth.

Composition

Active ingredient: bupivacaine;

1 ml of bupivacaine hydrochloride monohydrate equivalent to 5 mg of bupivacaine hydrochloride;

Excipients: sodium chloride, sodium hydroxide and/or hydrochloric acid, water for injections.

Contraindication

Method of application

Marcaine should only be administered by or under the supervision of physicians experienced in regional anesthesia. Small doses should be used to achieve adequate anesthesia.

It is important to take special care to prevent accidental intravascular injection. It is recommended to perform an aspiration test before and during the administration of the total dose. The total dose should be administered slowly, at a rate of 25-50 mg/min or in divided doses, maintaining constant verbal contact with the patient and monitoring the heart rate.

Application features

Pregnant women

Should not be used in early pregnancy unless the benefits are considered to outweigh the risks.

Children

Use for anesthesia in children aged 1 year and older as directed.

Drivers

With caution.

Overdose

Accidental intravascular injections of local anesthetics can cause immediate (seconds to minutes) systemic toxic reactions. In case of overdose, systemic toxicity occurs later (15-60 minutes after injection) due to the slower increase in blood concentrations of the local anesthetic.

Side effects

Adverse reactions caused by the drug itself are difficult to distinguish from the physiological effects of nerve fiber blockade (e.g., decreased blood pressure, bradycardia), as well as phenomena caused directly (e.g., nerve injury) or indirectly (e.g., epidural abscess) by needle puncture.

Interaction

Caution should be exercised when using bupivacaine with drugs structurally similar to local anesthetics, such as class IC antiarrhythmics, as their toxic effects are additive.

Specific interaction studies between local anesthetics and class III antiarrhythmics (e.g. amiodarone) have not been performed, but caution is advised in this case.

Storage conditions

Store at a temperature not exceeding 25 °C.

Do not freeze. Keep out of reach of children.

Shelf life - 3 years.