Medacet-1000 powder for solution for injection 1000 mg vial No. 1




Medacet powder for injection is indicated for the treatment of the following infections in adults and children, including newborns:
community-acquired pneumonia; respiratory tract infections in patients with cystic fibrosis; bacterial meningitis; chronic otitis media; malignant otitis externa; complicated urinary tract infection; complicated skin and soft tissue infection; complicated abdominal infection; bone and joint infections; dialysis-associated peritonitis in patients on continuous ambulatory peritoneal dialysis.Treatment of bacteremia occurring in patients as a result of any of the above infections.
Composition
Active ingredient: ceftazidime.
1 vial contains ceftazidime pentahydrate equivalent to ceftazidime 1000 mg.
Excipients: sodium carbonate.
Contraindication
Hypersensitivity to ceftazidime or to any of the excipients. Hypersensitivity to cephalosporin antibiotics. History of severe hypersensitivity (e.g. anaphylactic reactions) to other β-lactam antibiotics (penicillins, monobactams and carbapenems).Method of application
Medacet is administered by injection or infusion or by deep intramuscular injection. Recommended sites for intramuscular administration are the upper outer quadrant of the gluteus maximus muscle or the lateral aspect of the thigh.
Ceftazidime solutions can be administered directly into a vein or into an intravenous infusion system if the patient is receiving fluids parenterally.
The dose depends on the severity of the disease, sensitivity, location and type of infection, as well as the patient's age and renal function.
Application features
Pregnant women
The drug should be prescribed to pregnant women only when the benefits of its use outweigh the possible risks.
Children
Apply to children from the first days of life.
Drivers
However, certain side effects (e.g. dizziness) may occur, which may affect the ability to drive or use other machinery.
Overdose
Overdose may result in neurological complications such as encephalopathy, convulsions and coma. Symptoms of overdose may occur in patients with renal insufficiency unless the dose is reduced accordingly. Serum ceftazidime concentrations can be reduced by haemodialysis or peritoneal dialysis.
Adverse reactions
From the side of the circulatory and lymphatic system: often - eosinophilia and thrombocytosis. From the side of the gastrointestinal tract: often - diarrhea. From the digestive system: often - transient increase in the level of one or more liver enzymes (ALT, AST, LDH, GGT, LF). From the side of the skin and subcutaneous tissue: often - maculopapular rash or urticaria. General and administration site disorders: often - pain and / or inflammation at the injection site.Interaction
Like other antibiotics, the drug may affect the intestinal flora, leading to reduced estrogen reabsorption and reduced effectiveness of combined oral contraceptives.
Storage conditions
Store at a temperature not exceeding 30 °C in the original packaging. Keep out of the reach of children.
Shelf life - 2 years.
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