Instructions Medikhronal-Darnitsa granules pack set No. 21
Composition
package number 1:
active ingredient: 1 packet contains: glucose monohydrate 17.5 g;
excipient: povidone;
package number 2:
active ingredients: 1 packet contains: glycine 7 g; sodium formate 3.5 g;
excipient: povidone.
Dosage form
Granules.
Main physicochemical properties: white or white with a yellowish tinge granules, odorless.
Pharmacotherapeutic group
Drugs used for alcohol addiction.
ATX code N07B B.
Pharmacological properties
Pharmacodynamics
The drug Medichronal®-Darnitsa is a combined agent that helps reduce the accumulation of toxic alcohol metabolites in the body, in particular acetaldehyde (an oxidation product of ethanol).
The drug has a detoxifying effect, improves metabolic processes in the body, enhances the synthesis of catecholamines, especially noradrenaline, which improves neuromediation processes, stimulates the limbic-reticular complex, and increases the functional activity of the cerebral cortex.
The drug Medichronal®-Darnitsa has a positive effect on liver function, and also improves sleep and general well-being.
The reduction of symptoms of acute alcohol intoxication, symptoms of mild and moderate withdrawal syndrome occurs within 20-30 minutes after taking the drug.
Pharmacokinetics
Aminoacetic acid is rapidly absorbed in the digestive tract. It has almost 100% bioavailability. It easily penetrates most body fluids and tissues. It is destroyed in the liver by the enzyme glycine oxidase.
Sodium formate is rapidly absorbed in the digestive tract. In the systemic bloodstream and tissues of the body, it reacts with acetaldehyde to form conjugates that participate in the tricarboxylic acid cycle, increasing the formation of macroergic compounds.
Indication
Alcohol intoxication, withdrawal state; to increase the effectiveness of other methods of therapy; prevention of intoxication; secondary prevention of alcoholism.
Contraindication
Hypersensitivity to the components of the drug; severe forms of diabetes mellitus, arterial hypotension.
Interaction with other medicinal products and other types of interactions
The active ingredient of the drug, glycine, reduces the toxicity of anticonvulsants, antipsychotics, and antidepressants.
When combined with tranquilizers, hypnotics and antipsychotics, the inhibitory effect on the central nervous system is enhanced.
Medichronal®-Darnitsa can be combined with other drugs for the treatment of alcohol dependence, except for disulfiram. Disulfiram can be used after courses of treatment with Medichronal®-Darnitsa, if necessary.
Application features
Medichronal®-Darnitsa can be used both independently and in complex treatment. When prescribing treatment, it is necessary to apply an individual approach, which may include changes in the duration of treatment or an increase in the number of repeated courses during the year.
Patients prone to arterial hypotension should monitor blood pressure (BP) and, if necessary, adjust the dose of the drug (prescribe the drug in lower doses and subject to regular monitoring of blood pressure). If BP decreases below normal levels, the drug should be discontinued.
Since the drug contains glucose, the restriction to use is conditions accompanied by hyperglycemia.
Use during pregnancy or breastfeeding
The effect of the drug on the body during pregnancy or breastfeeding has not been studied in detail, therefore the use of the drug is not recommended.
Ability to influence reaction speed when driving vehicles or other mechanisms
During treatment, caution should be exercised when driving vehicles and working with complex mechanisms.
Method of administration and doses
Medichronal®-Darnitsa is prescribed to adults orally after meals, having previously dissolved the contents of both sachets in 200 ml of warm water. A single dose is 28.5 g (total weight of the components of both sachets). To improve the taste, the contents of the sachets can be dissolved in non-carbonated drinks (juice, compote, etc.).
To relieve acute alcoholic conditions, the drug should be used on the first day 1-2 times (after 10-12 hours) in a dose of 28.5 g, in the next 2-3 days - 28.5 g once a day.
To prevent intoxication, it is necessary to take a single dose (contents of packets No. 1 and No. 2) 30 minutes before drinking alcoholic beverages.
Children
Studies on the efficacy and safety of the drug in children have not been conducted.
Overdose
There is no information about the clinical manifestations of overdose.
Symptoms: In case of overdose, digestive disorders (nausea, bloating, diarrhea) and increased manifestations of adverse reactions are possible.
Treatment: Symptomatic therapy.
Adverse reactions
All components of the drug Medichronal®-Darnitsa are natural metabolites, so it is well tolerated. In some cases, the following side effects are possible:
Gastrointestinal: nausea;
from the nervous system: headache, tension, irritability, impaired concentration;
Immune system: hypersensitivity reactions, including rash, itching, urticaria.
Expiration date
3 years.
Do not use the medicine after the expiry date stated on the packaging.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
Granules in package No. 1 and package No. 2; package No. 1 and package No. 2 in a pack; 7 packages No. 1 and 7 packages No. 2 in a pack; 21 packages No. 1 and 21 packages No. 2 in a pack.
Vacation category
Without a prescription.
Producer
PrJSC "Pharmaceutical Company "Darnitsa".
Location of the manufacturer and its business address
Ukraine, 02093, Kyiv, Boryspilska St., 13.
