Powder for solution for injection or infusion Medoklav is indicated for the treatment of bacterial infections caused by microorganisms sensitive to Medoklav, such as:
severe infections of the throat, nose and ear (mastoiditis, peritonsillar infections, epiglottitis and sinusitis with accompanying severe systemic signs and symptoms); exacerbation of chronic bronchitis (after confirmation of the diagnosis); community-acquired pneumonia; cystitis; pyelonephritis; skin and soft tissue infections, including bacterial cellulitis, animal bites, severe dentoalveolar abscesses with widespread cellulitis; bone and joint infections, including osteomyelitis; intra-abdominal infections; genital infections in women.
Prevention of bacterial infections during major surgical interventions in the following areas:
gastrointestinal tract; pelvic organs; head and neck; biliary tract.
Composition
Active ingredients: amoxicillin, clavulanic acid;
1 vial contains amoxicillin sodium equivalent to amoxicillin 1 g and clavulanate potassium equivalent to clavulanic acid 0.2 g
Contraindication
Hypersensitivity to the active substances, penicillin and other components of the drug.
History of a severe immediate-type allergic reaction (e.g. anaphylaxis) to another beta-lactam antibiotic (cephalosporin, carbapenem or monobactam).
History of jaundice/liver dysfunction caused by amoxicillin/clavulanic acid.
Method of application
Doses are given as the content of amoxicillin / clavulanic acid, or even the indicated dose of the individual component.
When choosing a dose of Medoklav for the treatment of a particular infection, it is necessary to consider:
the expected pathogens and their expected susceptibility to antibacterial agents (see section; severity and location of the infection; age, body weight and renal function status of the patient, as described below.
This dosage form of Medoklav can be used in a daily dose of up to 3000 mg of amoxicillin and 600 mg of clavulanic acid. If it is necessary to use a high dose of amoxicillin, another form of Medoklav should be prescribed to avoid excessively high daily doses of clavulanic acid.
The duration of treatment is determined by the doctor individually. Some infections (for example, osteomyelitis) require long-term treatment. The duration of treatment should not exceed 14 days without evaluating the results of the application and the clinical picture.
Application features
Pregnant women
The use of the drug during pregnancy should be avoided, except in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
Children
Apply to children from the first days of life.
Drivers
No studies have been conducted to study the ability to influence the reaction rate when driving vehicles or operating other mechanisms. However, the occurrence of such adverse reactions as allergic reactions, dizziness, convulsions may affect the ability to drive vehicles or operate other mechanisms.
Overdose
Overdose may be accompanied by gastrointestinal symptoms and disturbances of water and electrolyte balance. These symptoms are treated symptomatically, with special attention to the correction of water and electrolyte balance.
Amoxicillin crystalluria may occur, which can sometimes lead to renal failure. There are reports of amoxicillin precipitation in the urinary catheter when using intravenous Medoclav in high doses. The patency of the catheter should be checked regularly.
Medoklav can be removed from the bloodstream by hemodialysis.
Side effects
Infections and infestations. Often - candidiasis of the skin and mucous membranes. From the blood and lymphatic system. Rarely - reversible leukopenia (including neutropenia) and thrombocytopenia. From the immune system. Frequency unknown - angioedema; anaphylaxis; serum sickness-like syndrome; allergic vasculitis. From the nervous system. Uncommon - dizziness, headache. From the vascular system. Rarely - thrombophlebitis at the injection site. From the gastrointestinal tract. Often - diarrhea. Uncommon - nausea, vomiting, indigestion. From the hepatobiliary system. Uncommon - moderate increase in AST and / or ALT levels is observed in patients receiving beta-lactam antibiotics. From the skin and subcutaneous tissue. Uncommon - skin rash, itching, urticaria. Rarely - erythema multiforme.
Interaction
Concomitant use of probenecid is not recommended. Probenecid reduces the tubular secretion of amoxicillin. Concomitant use of Medoklav may lead to prolonged elevation of blood levels of amoxicillin, but not of clavulanic acid.
Concomitant use of allopurinol during treatment with amoxicillin increases the likelihood of allergic skin reactions. There are no data on the simultaneous use of Medoklav and allopurinol.
Like other antibiotics, Medoklav may affect the intestinal flora, leading to reduced reabsorption of estrogens and reduced effectiveness of combined oral contraceptives.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Shelf life - 2 years.
