Meldonium solution for injection 100 mg/ml ampoule 5 ml No. 10

Meldonium injection solution is indicated in the complex therapy of diseases:

Composition

Active ingredient: meldonium;

1 ml meldonium (3-(2,2,2-trimethylhydrazinium) propionate dihydrate) 100 mg;

5 ml of solution (1 ampoule) contain meldonium (3-(2,2,2-trimethylhydrazinium) propionate dihydrate) 500 mg;

Excipients: sodium hydroxide, diluted hydrochloric acid, water for injections.

Contraindication

Method of application

Intravenously. The use of the drug does not require special preparation before administration.

Due to the possible stimulating effect, the drug is recommended to be used in the morning.

Adults. The dose is 500-1000 mg (5-10 ml) into a vein, administered as a single dose or in two divided doses. The duration of treatment is usually 10-14 days, after which the treatment is continued with an oral dosage form. The duration of the course of treatment is 4-6 weeks. The course of treatment can be repeated 2-3 times a year.

Elderly patients. Elderly patients with impaired liver and/or kidney function may require a reduced dose of meldonium.

Patients with renal impairment. Since the drug is excreted from the body by the kidneys, patients with mild to moderate renal impairment should use a lower dose of meldonium.

Patients with hepatic impairment. Patients with mild to moderate hepatic impairment should be given a lower dose of meldonium.

Application features

Pregnant women

Contraindicated.

Children

Contraindicated.

Overdose

There have been no reports of overdoses of meldonium. The drug is low-toxic and does not cause any dangerous side effects.

Low blood pressure may cause headache, dizziness, tachycardia, and weakness. Treatment is symptomatic.

In case of severe overdose, liver and kidney function should be monitored.

Hemodialysis is not of significant importance in case of meldonium overdose due to pronounced binding to blood proteins.

Side effects

Interaction

Meldonium can be used together with long-acting nitrates and other antianginal drugs (stable angina of exertion), cardiac glycosides and diuretics (heart failure). It can also be combined with anticoagulants, antiplatelet agents, antiarrhythmics and other drugs that improve microcirculation.

Meldonium may enhance the effects of drugs containing glyceryl trinitrate, nifedipine, beta-blockers and other antihypertensive agents and peripheral vasodilators.

Storage conditions

Store at a temperature not exceeding 25 °C in the original packaging. Do not freeze.

Keep out of reach of children.

Shelf life - 2 years.