Merkana capsules No. 20

Composition

1 capsule contains: active ingredient: patented undenatured cartilage collagen type II UC-IItm* - 40.0 mg (mg); excipients: filler: microcrystalline cellulose (E460), anti-caking agents: calcium phosphate (E341), amorphous silicon dioxide (E551), magnesium stearate (E572); capsule shell: gelatin, dye: titanium dioxide (E171).

GMO-free.

Recommendations for use

Mercana is recommended as a dietary supplement to the diet as an additional source of undenatured collagen type II UC-II™ to eliminate joint inflammation, normalize the functional state of joints, in particular during physical exertion. It helps eliminate inflammation and reduce joint stiffness, improve their mobility and flexibility.

Studies have shown that taking 40 mg (mg) of undenatured collagen type II (UC-II™) capsules daily can help relieve joint discomfort and restore healthy joint function and flexibility. Studies have also shown that taking 40 mg (mg) of undenatured collagen type II (UC-II™) capsules daily for 90 days for certain conditions (such as those requiring cartilage repair) may result in greater improvements than taking a glucosamine (1500 mg (mg)/day) and chondroitin (1200 mg (mg)/day) complex.

The difference between undenatured type II collagen and denatured (or hydrolyzed) collagen is the preservation of the three-dimensional configuration of the molecule itself (undenatured type II collagen) and the presence of active epitopes. It is believed that undenatured type II collagen, when administered orally, penetrates from the intestinal lumen into the intestinal Peyer's patches and promotes the formation of specialized regulatory T lymphocytes (T-regulators), which are able to produce anti-inflammatory cytokines, such as interleukin-10 (IL-10), interleukin-4 (IL-4) and transforming growth factor-β (TGF-β). These cytokines are able to penetrate into the synovial fluid of the joint through the circulatory system of the synovium and subchondral bone.

Anti-inflammatory cytokines IL-10, IL-4, TGF-β are able to suppress inflammation and improve cartilage metabolism. IL-10 affects the receptors of macrophages and synoviocytes, inhibiting the release of interleukin-1 (IL-1). TGF-β stimulates the synthesis of the intercellular substance (matrix) of cartilage by inhibiting the catabolic activity of chondrocytes (which led to the breakdown of collagen and other extracellular matrix proteins) and activating the anabolic function and proliferation of chondrocytes. In addition, IL-10 and TGF-β contribute to an increase in the production of interleukin-4 (IL-4). This contributes to the switching of chondrocyte metabolism towards the synthesis of intercellular matrix components.

Undenatured type II collagen helps reduce inflammation in the joints and improve articular cartilage metabolism.

Method of application

Adults should take 1 capsule once a day on an empty stomach before bedtime, with a glass of water. It is recommended to consult a doctor before use.

The recommended duration of use is 2-6 months. If necessary, the course can be repeated.

Reservation

Do not exceed the recommended daily dose. Mercan should not be used as a substitute for a balanced diet.

Contraindication

Individual sensitivity to any of the components, pregnancy and lactation.

Storage conditions

Store in the original packaging at a temperature of 4°C to 25°C in a dry place, protected from light and out of the reach of children.

Release form

Capsules.

Producer

Laboratorios Virens SL, Spain, Industria 48-B Poligono Industrial Nord-Est 08740 Sant Andreu de la Barca, Barcelona.