Metafora-SR tablets 1000 mg No. 30

Metafora – SR is an oral hypoglycemic agent. Metformin. Indications for use

Warehouse

Contraindication

Method of application

Reducing the risk or delaying the onset of type 2 diabetes

Metformin should only be prescribed when lifestyle changes within 3–6 months do not provide adequate glycemic control.

Treatment should be initiated with one extended-release tablet of metformin hydrochloride 500 mg once daily with the evening meal.

After 10–15 days of treatment, the dose should be adjusted according to the results of blood glucose measurements (OGTT (oral glucose tolerance test) and/or fasting plasma glucose and/or HbA1c should be normal). A slow increase in dose may improve gastrointestinal tolerability. The maximum recommended dose of Metformin®-SR 1000 mg is 2 tablets (2000 mg) taken with food in the evening.

Application features

In case of dehydration (severe diarrhea or vomiting, fever, or decreased fluid intake), it is recommended to temporarily discontinue metformin and seek medical attention.

Pregnant women

In case of pregnancy, the use of metformin for the treatment of impaired glycemic control or diabetes is not recommended.

Children

The drug should not be used in children, as there are no clinical data on its use in this age group of patients.

Drivers

The drug Metformin®-SR does not affect the speed of reactions when driving or working with other mechanisms, since monotherapy with the drug does not cause hypoglycemia.

However, caution should be exercised when metformin is used in combination with other hypoglycemic agents (sulfonylureas, insulin, meglitinides) due to the risk of hypoglycemia.

Overdose

When using the drug at a dose of 85 g, hypoglycemia was not observed. However, in this case, the development of lactic acidosis was observed. A significant excess of the metformin dose or concomitant risk factors can cause the occurrence of lactic acidosis. Lactic acidosis is an emergency. In the event of lactic acidosis, the drug should be discontinued and the patient urgently hospitalized. The most effective measure for removing lactate and metformin from the body is hemodialysis.

Side effects

From the nervous system: taste disturbance.

Gastrointestinal: digestive system disorders such as nausea, vomiting, diarrhea, abdominal pain, lack of appetite.

Hepatobiliary system: isolated reports of abnormal liver function tests or hepatitis, which completely disappeared after metformin discontinuation.

Storage conditions

Store in the original packaging at a temperature not exceeding 25°C.

Keep out of reach of children.