Metamin tablets are indicated for:
In type 2 diabetes mellitus when diet therapy and exercise regimen are ineffective, especially in patients with excess body weight. As monotherapy or combination therapy together with other oral hypoglycemic agents or together with insulin for the treatment of adults. As monotherapy or combination therapy with insulin for the treatment of children aged 10 years and adolescents. To reduce the complications of diabetes in adult patients with type 2 diabetes mellitus and excess body weight as a first-line drug when diet therapy is ineffective.
Composition
Active ingredient: metformin hydrochloride;
1 tablet contains metformin hydrochloride 500 mg or 850 mg or 1000 mg;
Excipients: lactose, povidone, magnesium stearate, colloidal silicon dioxide, hydroxypropylmethylcellulose.
Contraindication
Hypersensitivity to metformin or any component of the drug; any type of acute metabolic acidosis (e.g. lactic acidosis, diabetic ketoacidosis); diabetic coma; severe renal failure (glomerular filtration rate (GFR) <30 ml/min); acute conditions with a risk of developing renal dysfunction, such as: dehydration, severe infectious diseases, shock; diseases that can lead to tissue hypoxia (especially acute diseases or exacerbation of chronic diseases); decompensated heart failure, respiratory failure, recent myocardial infarction, shock; hepatic failure, acute alcohol poisoning, alcoholism.
Method of application
Usually the starting dose is 500 mg or 850 mg 2-3 times a day during or after meals.
After 10-15 days, the dose should be adjusted according to the results of serum glucose measurements.
Slowly increasing the dose helps reduce side effects from the digestive tract.
When treating with high doses (2000-3000 mg per day), it is possible to replace every 2 tablets of the drug Metamin, 500 mg with 1 tablet of the drug Metamin, 1000 mg.
The maximum recommended dose is 3000 mg per day, divided into 3 doses.
If switching from another antidiabetic agent, this agent should be discontinued and metformin should be prescribed as described above.
Application features
Pregnant women
When planning a pregnancy, as well as in the event of pregnancy, it is recommended to use metformin to treat diabetes, and insulin to maintain blood glucose levels as close to normal as possible, to reduce the risk of developing fetal defects.
Children
The drug Metamin is used to treat children aged 10 years and older.
Drivers
With caution
Overdose
When using the drug at a dose of 85 g, hypoglycemia was not observed. However, in this case, the development of lactic acidosis was observed. A significant excess of the metformin dose or concomitant risk factors can lead to the occurrence of lactic acidosis. Lactic acidosis is an emergency. In the event of lactic acidosis, treatment with the drug must be discontinued and the patient urgently hospitalized. The most effective measure for removing lactate and metformin from the body is hemodialysis.
Side effects
Nervous system disorders: Common: taste disturbance.
Gastrointestinal tract. Very common: digestive system disorders such as: nausea, vomiting, diarrhea, abdominal pain, lack of appetite. Most often, these side effects occur at the beginning of treatment and in most cases disappear spontaneously. To prevent the occurrence of side effects from the gastrointestinal tract, a slow increase in the dose of the drug is recommended.
Interaction
Alcohol. Acute alcohol intoxication is associated with an increased risk of lactic acidosis, especially in cases of fasting or low-calorie diet, as well as in liver failure. When treating with Metamin, ethanol and ethanol-containing drugs should be avoided.
Combinations that should be used with caution. Drugs that have a hyperglycemic effect (systemic and local corticosteroids, sympathomimetics). It is necessary to monitor blood glucose levels more often, especially at the beginning of treatment. During and after discontinuation of such combined therapy, it is necessary to adjust the dose of Metamin under the control of glycemia.
Storage conditions
Store at a temperature not exceeding 25ºС.
Keep out of reach of children!
Shelf life - 3 years.
