Metaphor tablets 850 mg No. 30




Metafor tablets are indicated for:
Type 2 diabetes mellitus when diet therapy and exercise regimen are ineffective, especially in overweight patients: as monotherapy or combination therapy in combination with other oral hypoglycemic agents, or in combination with insulin for the treatment of adults; as monotherapy or combination therapy with insulin for the treatment of children aged 10 years and adolescents. To reduce the complications of diabetes in adult patients with type 2 diabetes mellitus and overweight as a first-line drug after ineffective diet therapy.Composition
active ingredient: metformin hydrochloride; 1 tablet contains metformin hydrochloride 850 mg, which corresponds to metformin 662.9 mg; excipients: povidone; magnesium stearate; shell: Opadry Clear film coating mixture: hypromellose; polyethylene glycol.Contraindication
Hypersensitivity to metformin or any other component of the drug; any type of acute metabolic acidosis (e.g. lactic acidosis, diabetic ketoacidosis); diabetic precoma; severe renal failure (glomerular filtration rate (GFR) < 30 ml/min); acute conditions with a risk of developing renal dysfunction: dehydration, severe infectious diseases, shock; diseases that may lead to the development of tissue hypoxia (especially acute diseases or exacerbation of chronic diseases): decompensated heart failure, respiratory failure, recent myocardial infarction, shock; hepatic failure, acute alcohol poisoning, alcoholism.Method of application
The usual starting dose is 500 mg or 850 mg (Metaphora®, film-coated tablets, 500 mg or 850 mg) 2-3 times daily with or after meals.
After 10-15 days, the dose should be adjusted according to the results of serum glucose measurements.
Slowly increasing the dose helps reduce side effects from the digestive tract.
Application features
Pregnant women
When planning a pregnancy, as well as in the event of pregnancy, it is recommended to use insulin, not metformin, to treat diabetes to maintain blood glucose levels as close to normal as possible, in order to reduce the risk of fetal malformations.
Children
The drug Metafora® should be used to treat children aged 10 years and older.
Drivers
Metformin monotherapy does not affect the reaction rate when driving or operating other mechanisms, since the drug does not cause hypoglycemia. However, caution should be exercised when using metformin in combination with other hypoglycemic agents (sulfonylureas, insulin or meglitinides) due to the risk of hypoglycemia.
Overdose
When using the drug in a dose of 85 g, hypoglycemia was not observed. However, in this case, the development of lactic acidosis was observed. A significant excess of the metformin dose or concomitant risk factors can cause the occurrence of lactic acidosis. Lactic acidosis is an emergency and should be treated in a hospital. The most effective measure for removing lactate and metformin from the body is hemodialysis.
Side effects
The most common adverse reactions at the beginning of treatment are nausea, vomiting, diarrhea, abdominal pain, and lack of appetite.
Interaction
Alcohol intoxication is associated with an increased risk of lactic acidosis, especially in the presence of starvation, malnutrition, or liver failure.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Shelf life - 2 years.
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