Instructions Methionine film-coated tablets 0.25 g blister No. 50
Composition
active ingredient: 1 tablet contains DL-methionine 250 mg;
excipients: potato starch, colloidal anhydrous silicon dioxide, calcium stearate, polysorbate;
shell: sugar, light magnesium carbonate, povidone, colloidal anhydrous silicon dioxide, talc, titanium dioxide (E 171), Ponceau 4R dye (E 124), yellow wax, light mineral oil.
Dosage form
Film-coated tablets.
Main physicochemical properties: round tablets with a biconvex surface, covered with a pink coating. Two layers are visible on the cross section. Imperfections are allowed on the surface of the tablets.
Pharmacotherapeutic group
Antidotes. ATX code V03A B26.
Pharmacological properties
Pharmacodynamics.
Methionine is an essential amino acid that participates in the processes of transmethylation. It has a lipotropic effect, promotes the synthesis of choline, phospholipids; participates in the synthesis of adrenaline, creatine; activates the action of hormones, vitamins, enzymes. It has detoxifying properties due to the ability to methylate toxic products. It reduces the concentration of cholesterol in the blood and increases the content of phospholipids.
Pharmacokinetics.
Easily absorbed from the intestines. As an essential sulfur-containing amino acid, it is used for protein synthesis and enters into various metabolic reactions - permethylation, deamination, decarboxylation. It is excreted in urine in small amounts.
Indication
Treatment and prevention of diseases and toxic lesions of the liver: toxic hepatitis, alcoholic hepatopathy, cirrhosis of the liver, poisoning with arsenic preparations, chloroform, benzene and hepatotoxic substances.
It is the basis of combination therapy for chronic alcoholism, diabetes mellitus, for the treatment of dystrophy that develops with protein deficiency after dysentery and infectious diseases, atherosclerosis, during severe surgical operations, and burns.
Contraindication
Acute viral hepatitis, hepatic encephalopathy, severe liver failure, hypersensitivity to the drug.
Interaction with other medicinal products and other types of interactions
The use of Methionine in a balanced ratio with other amino acids prevents its toxic effects.
Application features
In acute and chronic renal failure, caution should be exercised due to the risk of hyperazotemia. Unbalanced use of methionine in large doses can lead to damage to liver cells.
Due to the unpleasant odor, children should take the medicine with sweet syrup or jelly.
The medicine contains sugar, which should be taken into account by patients with diabetes.
Use during pregnancy or breastfeeding
During pregnancy or breastfeeding, the use of the drug is possible only if the benefit to the mother outweighs the potential risk to the fetus/child.
Ability to influence reaction speed when driving vehicles or other mechanisms
Data is missing.
Method of administration and doses
Adults should be prescribed 500-1500 mg 3-4 times a day.
Single doses for children: at the age of 3-6 years - 250 mg, from the age of 7 years - 500 mg.
The frequency of administration is 3-4 times a day.
The medicine should be taken 30 minutes to 1 hour before meals.
The course of treatment is 10-30 days or 10 days with 10-day breaks between these courses.
Children: This dosage form should not be used in children under 3 years of age.
Overdose
Symptoms: possible hypotension, tachycardia, disorientation.
Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy.
Side effects
On the part of the immune system: allergic reactions.
Gastrointestinal: nausea, vomiting.
Expiration date
4 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 ºС.
Keep out of reach of children.
Packaging
10 tablets in blisters.
10 tablets in a blister, 5 blisters in a pack.
Vacation category
Without a prescription.
Producer
JSC "KYIV VITAMIN FACTORY".
Location of the manufacturer and address of its place of business.
04073, Ukraine, Kyiv, Kopylivska St., 38.
Website: www.vitamin.com.ua.
