Instructions for Metovitan hard capsules blister No. 20
Composition
active ingredients: 1 capsule contains: DL-methionine – 291 mg; α-tocopherol acetate (vitamin E) – 7.5 mg; thiamine hydrochloride (vitamin B1) – 0.9 mg; nicotinamide (vitamin B3) – 0.68 mg; zinc sulfate heptahydrate, equivalent to zinc 0.03 mg – 0.14 mg;
excipients: microcrystalline cellulose, hypromellose, talc, banana flavoring;
capsule composition: gelatin, quinoline yellow (E 104), azorubine (E 122), ponceau 4R (E 124), titanium dioxide (E 171).
Dosage form
The capsules are hard.
Main physicochemical properties: hard gelatin capsules of cylindrical shape with an opaque white body and an opaque red cap, filled with microgranules from white to light yellow in color, with a specific odor.
Pharmacotherapeutic group
Vitamins. Multivitamins, other combinations.
ATX code A11A B.
Pharmacological properties
Pharmacodynamics.
A complex drug with targeted metabolic action. The rationally selected composition contributes to a more pronounced targeted biological action of the drug to increase the vitality of the human body in adverse conditions due to the synergistic regulatory action of the components on narrow links of cellular metabolism, primarily the reactions of bioenergetic metabolism, transmethylation and transsulfuration.
The drug promotes the absorption and conversion in tissues into biologically active forms of vitamins, both those that are part of it and those that enter the body with food.
Metovitan is an effective hepatoprotector, helps normalize intracellular metabolism in all organs, promotes detoxification of lipo- and hydroperoxides, reduces the concentration of cholesterol in the blood, increases the content of phospholipids, as a result of which it increases immunity, mental and physical performance, which in general leads to an increase in vitality, endurance of the body to the action of adverse environmental factors. The drug also increases appetite and normalizes digestion.
Methionine is an essential amino acid that is part of proteins, plays an important role in the synthesis of a number of biologically important compounds, activates the action of hormones, vitamins, and enzymes, and neutralizes toxic products.
Vitamin E has antioxidant properties, participates in the biosynthesis of heme and proteins, cell proliferation, other important processes of tissue metabolism, prevents hemolysis of erythrocytes. It is necessary for the development and functioning of connective tissue, as well as for strengthening the walls of blood vessels. Inhibits lipid peroxidation by free radicals. Activates phagocytosis and is used to maintain proper resistance of erythrocytes.
Vitamin B1 normalizes the functional activity of the nervous, cardiovascular and digestive systems.
Vitamin B3 participates in redox reactions, in the regulation of biochemical processes in the body by participating in the synthesis of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).
Zinc is one of the important trace elements that is part of many enzyme systems that regulate basic metabolic processes, namely, participating in protein synthesis and carbohydrate metabolism.
Pharmacokinetics.
The substances that make up the drug Metovitan are easily absorbed in the intestines and, as natural components of living cells, are quickly metabolized. The drug activates protein synthesis, various metabolic reactions: transmethylation, transsulfuration, deamination, decarboxylation. It is excreted in urine in small quantities. The activating effect caused by the administration of the drug is prolonged, so Metovitan is recommended to be taken intermittently, for example: during the week - take daily, the next week - a break, etc.
Clinical characteristics.
Indication
For the prevention and as part of complex therapy of liver diseases: non-alcoholic and alcoholic steatohepatitis, liver damage due to the use of toxic chemicals (arsenic, chloroform, benzene) and medicinal substances (including antibiotics).
In the postoperative period and the recovery period after illnesses, including intoxications of various origins.
In combination therapy for chronic alcoholism.
With increased mental and physical stress, especially in adverse environmental conditions.
To increase the body's resistance to infectious diseases, including colds.
Contraindication
Hypersensitivity to any of the components of the drug.
Hepatic encephalopathy, severe liver failure, acute viral hepatitis.
Homocystinuria is a congenital disease in which there is a disorder of the remethylation of homocysteine into methionine.
Interaction with other medicinal products and other types of interactions
Vitamin B1, by affecting polarization processes in the area of neuromuscular synapses, can weaken the curare-like effect of muscle relaxants.
The drug reduces the negative effects of toxic drugs on the body, including paracetamol.
Do not use with other multivitamins, as overdose of the latter is possible.
Application features
A specific urine odor may appear, which is not harmful. This is due to an increase in the concentration of sulfur-containing compounds in the urine - products of methionine metabolism.
With prolonged use of the drug, it is advisable to periodically analyze the content of homocysteine in the blood.
Use during pregnancy or breastfeeding
During pregnancy or breastfeeding, the drug is taken only on the recommendation of a doctor.
Ability to influence reaction speed when driving or using other mechanisms
There have been no reports of the drug affecting the ability to drive or operate other machinery.
Method of administration and doses
The drug is prescribed for therapeutic purposes to adults, 1 capsule 3 times a day.
For prevention in the fall and spring, during epidemics, the drug is recommended to be taken 2 capsules once a day.
Capsules should be taken orally 0.5 hours after meals in courses of 5-10 days with the same breaks.
The duration of treatment is determined by the doctor individually and can range from 2 weeks to 2 months.
Children
The drug in this dosage form is not intended for use in children.
Overdose
Symptoms: possible hypotension, tachycardia, disorientation.
Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy.
Adverse reactions
Adverse reactions may sometimes occur, mainly when used in high doses.
On the part of the immune system: in individuals with hypersensitivity, allergic reactions are possible, including anaphylactic shock, angioedema, hyperthermia, itching, skin rashes; rarely - bronchospasm in individuals with hypersensitivity to B vitamins.
Skin and subcutaneous tissue disorders: rash, urticaria, itching, redness of the skin.
On the part of the gastrointestinal tract: dyspeptic disorders, nausea, vomiting, diarrhea; rarely - increased secretion of gastric juice is possible.
From the nervous system: headache, dizziness, increased excitability, drowsiness.
In case of any adverse reaction, it is necessary to consult a doctor regarding further use of the drug. After reducing the dose or temporarily discontinuing the drug, adverse reactions disappear within 2-3 days.
Expiration date
3 years.
Storage conditions
Store in original packaging at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Packaging
10 capsules in a blister. 2 blisters in a cardboard pack.
Vacation category
Without a prescription.
Producer
Technolog PJSC.
Location of the manufacturer and address of its place of business
Ukraine, 20300, Cherkasy region, Uman city, Manuilskogo street, building 8.
