Neomycin Plus is an antibiotic for topical use.
Indications for use - bacterial infections of limited skin areas: bacterially infected herpes simplex, herpes zoster/chickenpox; contagious impetigo; infected varicose ulcers; infected eczema; bacterially infected diaper dermatitis. Prevention of umbilical cord infection in newborns.
Warehouse
active ingredients: 1 g of the drug contains bacitracin zinc 250 IU, neomycin sulfate 5000 IU; excipients: light magnesium oxide, corn starch.
Contraindication
Hypersensitivity to the components of the drug or to other aminoglycoside antibiotics. Significant and severe skin lesions (possible resorption of the drug with the development of an ototoxic effect with hearing loss). If uncontrolled absorption of the drug is possible, do not use in patients with severe cardiogenic or nephrogenic excretory disorders, as well as in the presence of a history of lesions of the vestibular and cochlear systems. Do not use in the external auditory canal with perforation of the eardrum and in areas around the eyes.
Method of application
Adults and children from birth should usually use Neomycin Plus powder 2 to 4 times a day.
After applying the powder to the affected areas of the skin, the natural process of evaporation (sweating) is activated, so the drug has a cooling, soothing effect.
The powder should be sprinkled over the surface to be treated. If necessary, a gauze bandage can be applied to the affected area after applying the drug.
Patients with burns covering more than 20% of the body surface should not use Neomycin Plus powder more than once a day, especially in cases of impaired renal function, as absorption of the active ingredients of the drug may occur.
When applied topically, the dose of neomycin should not exceed 1 g per day (equivalent to 200 g of powder) for more than 7 days. When repeated courses are used, the maximum dose should be halved.
Application features
When using the drug in patients with large areas of affected skin, the possibility of absorption of the active components of the drug and, as a result, the development of oto- and/or nephrotoxic effects should be taken into account. Since the risk of toxic effects increases in patients with severe liver and/or kidney disorders, such patients should be monitored for urine and blood parameters, and audiometric studies should be performed before and during intensive therapy with the drug.
Precautions should be taken with long-term use of the drug in patients with chronic otitis media due to possible ototoxic effects.
The combination of systemic and topical aminoglycosides should be avoided due to the risk of cumulative toxicity.
If uncontrolled absorption of the drug occurs, the possibility of neuromuscular blockade should be considered, especially in patients with acidosis, a history of myasthenia gravis, or other neuromuscular disorders. Neuromuscular blockade is eliminated with calcium preparations or proserin (neostigmine).
Pregnant women
If there is a risk of absorption of active substances during pregnancy or breastfeeding, the powder can be used during these periods only if the expected benefit to the mother outweighs the potential risk to the fetus or child. Like other aminoglycoside antibiotics, neomycin crosses the placental barrier. There have been reports of hearing impairment in the fetus due to systemic use of high doses of aminoglycosides.
Before breastfeeding, it is necessary to remove the remnants of the drug from the mammary gland with boiled water and sterile cotton wool.
Children
Use in children from the first days of life as prescribed by a doctor after a careful assessment of the benefit/risk ratio.
Drivers
Unknown.
Overdose
When using doses significantly exceeding the recommended ones, due to the possible absorption of the active substances of the drug, symptoms indicating nephro- and/or ototoxic reactions should be taken into account, especially in patients with trophic ulcers.
Treatment: therapy is symptomatic.
Side effects
On the part of the immune system: in the case of allergic reactions to neomycin, cross-allergy to other aminoglycoside antibiotics also occurs in approximately 50% of cases; hypersensitivity to neomycin and many other substances may occur in the case of use of the drug for chronic dermatoses or chronic otitis media.
From the nervous system: vestibular nerve damage, neuromuscular blockade.
From the side of the organs of hearing and labyrinth: ototoxicity.
Renal and urinary disorders: nephrotoxicity.
Storage conditions
Store in the original packaging at a temperature not exceeding 25°C.
Keep out of reach of children.
