Nitroglycerin concentrate for infusion solution 10 mg/ml ampoule 2 ml No. 10

Nitroglycerin concentrate for solution for infusion should be used for the following indications:

Composition

Active ingredient: nitroglycerin;

1 ml of glycerol trinitrate solution 5% in ethanol, calculated on 100% content of the main substance - 10.0 mg;

Excipients: ethanol (96%).

Contraindication

Hypersensitivity to nitroglycerin and other nitro compounds. Hypovolemia, severe arterial hypotension (systolic blood pressure <90 mm Hg), acute myocardial infarction localized in the right ventricle, increased intracranial pressure (due to head injury or cerebral hemorrhage), cardiac tamponade, hypertrophic obstructive cardiomyopathy, constrictive pericarditis, angle-closure glaucoma, toxic pulmonary edema, anemia, acute vascular insufficiency (shock, vascular collapse).

Sildenafil. Simultaneous use of the phosphodiesterase type 5 inhibitor sildenafil, since sildenafil potentiates the hypotensive effect of nitrates (the interval between doses should be at least 48 hours).

Method of application

The dosage regimen is set individually, depending on the clinical response and systolic blood pressure.

An infusion solution containing 100 mcg/ml nitroglycerin is usually used.

Application features

Pregnant women

Not recommended.

Overdose

Symptoms: hypotension, tachycardia, feeling of heat, flushing, headache, palpitations, fainting. Increased intracranial pressure, which can lead to confusion and neurological disorders. Overdose within a few hours can lead to ethanol intoxication.

Treatment. Excessive hypotension can be eliminated by reducing the infusion rate of the drug or stopping its administration. In case of severe arterial hypotension, the patient should be placed in a horizontal position with the head of the bed lowered. In case of hypotension associated with bradycardia, the use of atropine and dopamine is indicated. Hypoxia caused by methemoglobinemia can cause cyanosis, metabolic acidosis, coma, convulsions, vascular collapse. In case of methemoglobinemia, a solution of methylene blue (1-2 mg/kg body weight) is administered.

Side effects

In most cases, the side effects of nitroglycerin are associated with an excessive decrease in blood pressure.

Interaction

Sildenafil. Concomitant use of the phosphodiesterase type 5 inhibitor sildenafil is contraindicated, as sildenafil potentiates the hypotensive effect of nitrates (the interval between doses should be at least 48 hours).

Storage conditions

Store at a temperature of 8 °C to 15 °C in the original packaging away from fire.

Keep out of reach of children.

Shelf life - 3 years.