Instructions NovoMetril Pro sachet No. 20
Composition
TRANS-Resveratrol (from Polygonum Cuspidatum), Aescin (from Aesculus hippocastanum L.), Hyperoside (from Betula pendula Roth L.), Harpagoside (from Harpagophytum Procumbens (Burch.) DC.), Withanoids (from Withania somnifera), Genistein (Isoflavone), Narengin (Flavonoid), Green Tea Extract (EGCG), Ginsenosides (from Panax ginseng CA Mey.), Diosmin (Flavonoid), Ellagic Acid (from Punica granatum L.), Quercetin (from Sophora japonica L.), Bromelain, L-Cysteine, Alpha-Lipoic Acid, Folic Acid, Vitamin A, Vitamin E (DL-Alpha Tocopheryl Acetate), Vitamin C (L-Ascorbic Acid), Vitamin B1 (Thiamine Hydrochloride), Vitamin B2 (Riboflavin), Vitamin B3 niacin (nicotinamide), vitamin B6 (pyridoxine hydrochloride), biotin (D-biotin), vitamin B12 (cyanocobalamin), vitamin D3 (cholecalciferol), zinc oxide, magnesium oxide, sodium selenium, enzyme mix (Enzymix®), probiotic blend Lacto B5 (B. bifidum, L. Gasseri, L. Rhamnosus, B. sporogenes, S. Boulardii, B. coagulans).
Recommendations for use
- It is recommended to be used to normalize estrogen metabolism in estrogen-dependent diseases: endometrial hyperplasia, uterine fibroids, endometriosis, menstrual disorders, mastopathy, anogenital warts associated with human papillomavirus. The prevalence of endometriosis is 5-10% in reproductive age, and it increases to 20-30% in women with subfertility, and further increases to 40-60% in women with infertility. Mediators such as cyclooxygenase (PTGS2), monocyte chemotactic peptide (CCL2) and matrix metalloproteinase (MMP9), molecules that are partially regulated by NF-kB and steroid receptors, provoke symptoms of pelvic pain.
- NovoMetril PRO is a complex based on important biologically active molecules to improve the reproductive health of women with anovulatory dysfunction and endometriosis.
- Suppresses the expression of inflammatory biomarkers (TNF-a, COX-2, IL-y 1), transcription (NF-KB, PPAR-gamma) and induces antioxidant enzymes (catalase, superoxide dismutase).
- Affects cell signal transduction pathways, initiating transcription (STATZ), ribosomal protein S6-kinase beta-2 (RPS6KB2), inhibits mitotic protein kinase activity (MAPK1/3; ERK/2, MAPK14(p38)).
- Inhibits cell proliferation, increases apoptosis, modulates angiogenesis, extracellular matrix production, which play a huge role in the pathogenesis of endometriosis. Normalization of estrogen metabolism by induction of active cytochrome CYP1A1 Effectively eliminates immune disorders observed in women with ovarian endometriosis and a history of infertility.
- Inhibition of pathological cell proliferation by blocking intracellular signaling pathways from growth factors (EGF, IGF).
- Activates the production of pro-inflammatory cytokines IL-10.
- Stimulation of apoptosis in endometrial stromal cells through the production of a pro-apoptotic protein.
- Reduces the risk of ovarian reserve depletion and normalizes immunoendothelial indicators.
- Inhibits epidermal, insulin-like growth factors and TNF-a.
- Improves the restoration of the menstrual cycle in patients with endometriosis.
- Reduces symptoms of hyperandrogenism (dysmenorrhea, oligo-/amenorrhea).
- Reduces metabolic disorders characterized by (serum triglycerides, total cholesterol, high body mass index, high blood pressure, impaired glucose tolerance).
- Helps reduce oxidative stress and fatty liver disease. Hepatoprotector.
- Inhibits the enzyme 5-alpha-reductase, which is responsible for the symptoms of hyperandrogenism in women with endometriosis.
- Reduces homocysteine, cortisol, and leptin resistance.
- Correlates the level of Anti-Mullerian hormone in women with endometriosis.
- Improves nuclear-cytoplasmic maturation of Oocytes by normalizing the follicular environment, thereby improving Oocyte quality.
- Improves the results of assisted reproductive technology (ART) in women with endometriosis.
- Increases the synthesis of Sex Binding Globulin (SHBG).
- Inhibits the formation of estrogen metabolites by reducing oxidative stress.
- Reduces symptoms of subclinical hypothyroidism (which correlates with body mass index).
- Regulates gene transcription and post-translational histone acetylation.
- Inhibits adhesion and implantation of endometrial tissue by reducing reactive oxygen species.
- Inhibits proliferation and transformation in cells infected with human papillomavirus, inhibiting malignancy processes.
- Adjuvant therapy for endometritis.
- Diffuse, sclerotic, nodular and cystic adenomyosis.
- Intramural, submucosal and subserosal uterine fibroids.
- It acts as an adjunctive therapy for acute and chronic endometritis due to its antimicrobial and anti-inflammatory effects, preventing irritation and damage to the endometrium.
- Inhibits angiogenesis, migratory and invasive processes of epithelial-mesenchymal transition and the growth of endometrial polyps.
- Promotes better embryo implantation in assisted reproductive technologies (ART).
- Inhibits endometrial inflammation caused by dilation and curettage, abnormal uterine bleeding, hysteroscopy, endometrial biopsy.
Method of administration and doses
Women aged 18 to 60 should take one sachet once a day, after meals. Dissolve the contents of the sachet in a glass of cold water (200 ml) before use.
Contraindication
Individual sensitivity to ingredients. Do not exceed the recommended dose.
Precautions for use by certain categories of consumers (e.g. children, pregnant women)
Individual sensitivity to ingredients.
Storage conditions
Store in a cool, dry place, away from direct heat sources, at a temperature of +5 - +25 ° C. Keep out of the reach of children.
Release form
Oral powder in sachets. 1 sachet - 4 g/20 sachets in a box.
It is not a medicine.
Expiration date
The batch number is indicated on the packaging. Shelf life: 48 months.
Producer
Manufacturer: Gruppo Farmaimpresa SrI Via Cipro-1 25124 Brescia (BS) Italy/ Gruppo Farmaimpresa Srls, Via Cipro-125124 Brescia - Italy.
Importer in Ukraine: LLC "BIOVIVA", 76018, Ivano-Frankivsk, Danylo Halytskoho St., 67/1, Tel.: +380996241351, bioviva.italy@gmail.com
