Oftan Timolol eye drops 0.5% bottle with dropper 5 ml

Pharmacological properties

Antiglaucoma agent, non-selective β-adrenergic blocker. Timolol does not have sympathomimetic and membrane-stabilizing effects. The decrease in intraocular pressure is a consequence of a decrease in the production of aqueous humor when the drug is applied topically; the effect of timolol on the outflow of aqueous humor from the eye is insignificant. It does not affect the size of the pupil or accommodation. After instillation into the eye, timolol enters the systemic bloodstream through the conjunctiva, the mucous membrane of the nasal cavity and the digestive tract. When taken orally, the drug is well absorbed, then rapidly metabolized. Inactive metabolites are excreted mainly in the urine. The duration of action is 10-20 hours, which allows the drug to be used 2 times a day. Intraocular pressure begins to decrease 30 minutes after instillation of the drug, and its maximum decrease is observed after 3-4 hours.

Indication

Increased intraocular pressure, open-angle glaucoma; glaucoma due to aphakia; main types of secondary glaucoma.

Application

0.25% or 0.5% solution - 1 drop (30 μl) 1-2 times a day in the affected eye. It is recommended to start treatment with a 0.25% solution; if the effect is insufficient, 0.5% solution should be used. Intraocular pressure should be measured 3-4 weeks after the start of treatment and then regularly, at regular intervals.

Contraindication

Heart failure, heart rhythm disturbances, especially AV block II-III degree, bradycardia, BA, COPD, tendency to bronchospasm, hypersensitivity to timolol maleate or benzalkonium chloride.

Side effects

Decreased lacrimation, superficial punctate keratopathy and corneal anesthesia, conjunctivitis, blepharitis, nonspecific eye symptoms; these phenomena disappear after discontinuation of the drug. Possible systemic side effects: bradycardia, hypotension and increased symptoms of circulatory failure; headache, dry mouth, nausea, heart rhythm disturbances, dizziness have also been described, but a clear causal relationship with the use of the drug has not been established. Patients with a tendency to allergic reactions may develop a rash, urticaria. The condition of patients with myasthenia gravis may worsen when using timolol in the form of eye drops.

Special instructions

The drug should not be used in newborns and young children.

During pregnancy or breastfeeding, the drug is prescribed only if the expected benefit to the mother outweighs the potential risk to the fetus or child.

The use of the drug does not affect the ability to drive vehicles. Oftan Timolol eye drops contain benzalkonium chloride as a preservative, which can settle on soft contact lenses, so they should be removed before instillation of the drug and put back on after 15 minutes. During treatment, intraocular pressure should be regularly monitored.

Interactions

Oftan timolol can be combined with other agents for the treatment of glaucoma (miotics, adrenaline and carbonic anhydrase inhibitors), with the exception of other β-adrenergic blockers. In patients taking concomitant oral β-adrenergic blockers or calcium antagonists, the risk of local and systemic side effects increases. The drug should be prescribed with caution to patients who are scheduled for surgery under general anesthesia, since the risk of developing arterial hypotension and asystole during anesthesia in patients who have received β-adrenergic blockers before surgery increases.

Overdose

Systemic reactions are possible, including bradycardia, hypotension, acute heart failure and bronchospasm. In case of severe bradycardia or bronchospasm, isoprenaline is administered intravenously; in case of arterial hypotension, dobutamine; in case of acute heart failure, cardiac glycosides, diuretics and oxygen therapy are prescribed.

Storage conditions

In a place protected from light at a temperature of 15-25 ° C. the drug in an open bottle can be used for 1 month.