Instructions for Okomistin eye, ear, nose drops 0.01% bottle with dropper 5 ml
Composition
active ingredient: benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride monohydrate;
1 ml of solution contains benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride monohydrate (calculated on the anhydrous substance) 0.1 mg;
Excipients: sodium chloride, water for injections.
Dosage form
Eye/ear/nose drops.
Main physicochemical properties: colorless transparent liquid.
Pharmacotherapeutic group
Means used in ophthalmology and otology. ATX code S03D.
Anti-edematous and other drugs for topical use in diseases of the nasal cavity. ATX code R01A.
Pharmacological properties
Pharmacodynamics.
Benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride monohydrate is a cationic surfactant with antimicrobial (antiseptic) action. The action of Okomistin ® is based on the direct hydrophobic interaction of the molecule with the lipids of the membranes of microorganisms, which leads to their fragmentation and destruction. At the same time, part of the molecule of the active substance, immersing in the hydrophobic area of the membrane, destroys the supramembrane layer, loosens the membrane, increases its permeability for high-molecular substances, changes the enzymatic activity of the microbial cell, inhibits enzyme systems, which causes inhibition of the vital activity of microorganisms and their cytolysis. Unlike other antiseptics, Okomistin ® has a high selectivity of action against microorganisms, since it practically does not affect the membranes of human cells. This effect is associated with a different structure of human cell membranes (a significantly longer length of lipid radicals, which sharply limits the possibility of hydrophobic interaction of the active substance with cells). Okomistin ® has a pronounced antimicrobial effect against gram-positive and gram-negative, aerobic and anaerobic, spore-forming and asporogenic bacteria in the form of monocultures and microbial associations, including hospital strains with multi-resistance to antibiotics. It has a detrimental effect on pathogens of sexually transmitted diseases - gonococci, pale treponema, trichomonads, chlamydia, as well as herpes viruses, human immunodeficiency. It has an antifungal effect on ascomycetes of the genus Aspergillus and the genus Penicillium, yeast ( Rhodotorula rubra, Torulopsis gabrata ) and yeast-like ( Candida albicans, Candida krusei ) fungi, dermatophytes ( Trichophyton rubrum, Trichophyton mentagrophytes, Trichopphyton verrucosum, T. schoenleinii, T. violaceum, Epidermophyton Kaufman-Wolf, E. floccosum, Microsporum gypseum, Microsporum canis ), as well as on other pathogenic fungi (for example, Pityrosporum orbiculare (Malassezia furfur ) in the form of monocultures and microbial associations, including fungal microflora with resistance to chemotherapeutic drugs. Under the action of Okomistin ® , the resistance of microorganisms to antibiotics decreases. Okomistin ® has an anti-inflammatory and immunoadjuvant effect, enhances local protective reactions, regenerative processes, activates mechanisms of nonspecific protection due to modulation of cellular and local humoral immune response, thereby accelerating recovery.
Pharmacokinetics.
Okomistin® has a local effect. There is no data on the possibility of the drug penetrating the systemic bloodstream.
Indication
In the complex treatment of infectious processes of the anterior segment of the eye (blepharitis, conjunctivitis, keratitis, keratouveitis) caused by gram-positive and gram-negative bacteria, chlamydia, fungi and viruses sensitive to Okomistin®, eye injuries, eye burns (thermal and chemical).
Prevention of ophthalmia neonatorum, including gonococcal and chlamydial ophthalmia.
Prevention and treatment of purulent-inflammatory eye lesions in the pre- and postoperative period.
In the complex treatment of acute and chronic otitis externa, chronic purulent mesotympanitis, otomycosis.
In the complex treatment of acute rhinitis.
Contraindication
Individual sensitivity to the components of the drug.
Interaction with other medicinal products and other types of interactions
When used together, Okomistin® increases the effectiveness of topical antibiotics.
If you are taking any other medications at the same time, you should inform your doctor.
Use during pregnancy or breastfeeding
Can be used during pregnancy. There is no data on the negative effects of the drug during breastfeeding.
Ability to influence reaction speed when driving vehicles or other mechanisms
The drug does not affect the speed of reactions when driving vehicles and other mechanisms.
Method of administration and doses
Ophthalmology
For the treatment of infectious processes of the anterior segment of the eye, adults and children over 12 years of age should instill 2-3 drops into the conjunctival sac, and children under 12 years of age should instill 1-2 drops 4-6 times a day. The duration of treatment usually does not exceed 2 weeks.
When treating eye burns, after rinsing the eye with plenty of water, perform frequent instillations (every 5-10 minutes) for 1-2 hours. For further treatment, the drug is used for adults and children over 12 years of age, 2-3 drops, for children under 12 years of age - 1-2 drops 4-6 times a day.
To prevent ophthalmia in newborns, immediately after birth, instill 1 drop of the drug into each eye 3 times with an interval of 2-3 minutes.
Otolaryngology
When treating acute and chronic external otitis, otomycosis, adults and children over 12 years of age should instill 3-5 drops 4-6 times a day; children under 12 years of age - 2-3 drops 4-6 times a day.
A gauze swab moistened with the drug can be inserted into the external auditory canal 4-6 times a day for 10-14 days (instead of instillation).
In chronic mesotympanitis, use in complex treatment using hardware ultrasonic irrigation or injection into the tympanic cavity together with antibiotics.
In the treatment of acute rhinitis, infections of the nasal mucosa, adults and children over 12 years of age should instill 2-3 drops, children under 12 years of age - 1-2 drops in each nasal passage 4-6 times a day. The course of treatment is 7-14 days.
Dosage features. Accurate dosing is achieved by pressing the bottom of the bottle – one press = 1 drop.
Children.
The drug can be used in pediatric practice.
Overdose
Not observed.
Side effects
Hypersensitivity reactions are possible when using the drug. In some cases, a short-term burning sensation is possible, which disappears on its own after 5-20 seconds and does not require discontinuation of treatment.
If any adverse reactions occur, you should consult a doctor!
Expiration date
3 years.
After first opening the bottle – 25 days.
The drug cannot be used after the expiration date indicated on the package.
Storage conditions
Store at a temperature not exceeding 35 °C in the original packaging out of the reach of children. Keep the bottle tightly closed between uses.
Packaging
5 ml or 10 ml in a polymer bottle with a dropper, 1 bottle in a cardboard pack.
Vacation category
According to the recipe.
Producer
JSC "Farmak".
Location of the manufacturer and address of its place of business.
Ukraine, 04080, Kyiv, Kyrylivska St., 74.
Applicant
KNVMP "ISNA".
Location of the applicant.
Ukraine, 04114, Kyiv, Dubrovytska St., building 8, room 160.
