Instructions Olazol aerosol can 60 g
Composition
active ingredients: sea buckthorn oil, chloramphenicol, benzocaine, boric acid;
1 bottle contains: sea buckthorn oil – 5.40 g; chloramphenicol – 1.62 g; benzocaine – 1.62 g; boric acid – 0.27 g;
excipients: triethanolamine, lanolin, stearic acid, glycerin, purified water, chladone 134a.
Dosage form
Aerosol.
Main physicochemical properties: the drug forms a yellow or yellowish foam with a slightly orange tint when released from the can.
Pharmacotherapeutic group
Means for the treatment of wounds and ulcers. ATX code D03A X.
Pharmacological properties
Pharmacodynamics
A combined drug that has an anesthetic, antibacterial (active against many gram-positive and gram-negative bacteria, pyogenic microbes, hemophilic bacteria, brucella, rickettsia, chlamydia, spirochetes) and anti-inflammatory effects, reduces exudation, promotes tissue regeneration and accelerates the process of wound epithelialization.
Pharmacokinetics
Data not presented. The drug has some degree of systemic action.
Indication
For the treatment of infected wounds, including non-healing burns, trophic ulcers, and loose skin grafts in adults and children aged 2 years and older;
in gynecology and proctology: bacterial vaginosis (acute and chronic recurrent), cervical erosion, chronic proctitis of various etiologies, anal fissures.
Contraindication
Hypersensitivity to any component of the drug, including excipients. Increased individual sensitivity to other amide local anesthetics. Allergy and toxic reaction (dyspeptic phenomena, dysbacteriosis, mental disorders) to chloramphenicol in history. Psoriasis, eczema, fungal skin diseases, suppression of bone marrow hematopoiesis, thromboembolic disease, granulocytopenia, periods of pregnancy or breastfeeding. Impaired renal function. Children's age up to 2 years.
Interaction with other medicinal products and other types of interactions
Do not use simultaneously with other antimicrobial agents for local (intravaginal) use.
Simultaneous use with erythromycin, oleandomycin, nystatin and levorin increases the antibacterial activity of the drug, and with benzylpenicillin salts it decreases it. It should not be prescribed simultaneously with drugs that inhibit hematopoiesis (sulfanilamides, pyrazolone derivatives, cytostatics), with diphenyl, barbiturates, ethanol.
It is not recommended to use the drug without clear medical indications and doctor's supervision while regularly taking monoamine oxidase inhibitors (MAO), antidepressants and antihypertensives due to the theoretical possibility of reducing the effect of MAO inhibitors or enhancing the effect of antihypertensives due to interaction with benzocaine in cases of significantly exceeding the recommended doses and duration of administration.
Application features
The contents of the canister are under pressure, so use the medicine with caution. Do not spray near an open flame. It is unacceptable to disassemble both the full and empty canister.
The use of antibacterial agents for external use may lead to skin sensitization, which is accompanied by the development of a hypersensitivity reaction (with further use of this medicinal product externally or in the form of a dosage form of systemic action).
In the presence of pus or necrotic masses, the antibacterial effect of the drug is preserved. The drug should not be allowed to get on the mucous membrane of the eyes.
Unless otherwise directed by a physician, do not exceed the recommended daily dose to minimize systemic adverse reactions.
You should not violate the rules for using the medicine.
With prolonged use, genital candidiasis develops.
With prolonged (longer than 1 month) use of the drug, it is necessary to monitor the state of the peripheral blood picture; if leukopenia occurs, the drug must be discontinued.
Uncontrolled treatment with a drug in pediatric practice should not be allowed - use only as prescribed by a doctor.
In case of heavy bleeding from the anus or if the symptoms of the disease do not disappear within 7 days of treatment or the condition worsens, it is necessary to consult a proctologist.
Use with caution as prescribed by a doctor in the following conditions: severe arterial hypertension, severe heart rhythm disturbances, clinically pronounced thyrotoxicosis, urination disorders.
There are reports that the use of products containing benzocaine has caused methemoglobinemia. Symptoms such as cyanosis of the skin, lips and nail beds, headache, dizziness, dyspnea (difficulty breathing), weakness, tachycardia, which may occur during treatment, may indicate methemoglobinemia, which is potentially life-threatening and requires urgent medical intervention.
The medicine contains lanolin and may therefore cause local skin reactions (e.g. contact dermatitis).
Ability to influence reaction speed when driving vehicles or other mechanisms
Not installed.
Use during pregnancy or breastfeeding
The medicine should not be used during pregnancy or breastfeeding.
Method of administration and doses
Before use, shake the aerosol can 10–15 times, remove the protective cap, put the spray nozzle on the valve stem and slowly press its head, as a result of which the medicine comes out of the can in the form of foam. Before and after using the medicine, the spray nozzle should be rinsed with boiled water.
For external use. If possible, clean the wound surface from pus and necrotic tissues and cover with an even layer (1–1.5 cm) of foam. Apply daily or every other day, for open treatment of wounds and burns in adults - 1–4 times a day, in children over 2 years old - 1–2 times a day, depending on the nature of the inflammation and the stage of regeneration of damaged tissues. To cover the entire wound surface, apply the foam from a distance of 1–5 cm. Press the spray nozzle head all the way down and immediately release - 7 ml of foam (approximately 1.4 g of the drug) is released from the canister, which is enough to cover a wound with a surface area of approximately 100 cm2. The duration of treatment is determined and monitored by the doctor individually.
When applied to the cavity. In case of gynecological diseases (bacterial vaginosis, cervical erosion), before introducing the drug into the vagina, in order to remove mucus, douche with an antiseptic solution (chamomile decoction or furatsilin solution 1: 5000, chlorhexidine bigluconate 0.02%, sodium bicarbonate 2%). After that, insert the free edge of the spray nozzle into the vagina to a depth of 1.5–2 cm, press its head all the way down and immediately release. In case of gynecological diseases, repeat the procedure 2 times a day. The course of treatment is 7–10 days.
For proctitis, first do a cleansing enema with a decoction of chamomile or calendula, then insert the free edge of the spray nozzle into the rectum to a depth of 2–4 cm, press its head all the way down and immediately release. The procedure is carried out once a day. The course of treatment is up to 2 weeks.
Children
Apply externally to children over 2 years of age.
Treatment of children should be carried out under the supervision of a physician.
There is no experience of use in gynecology and proctology in children, therefore the drug should not be used in children for these indications.
Overdose
External use of the drug in recommended doses does not cause overdose.
Prolonged and frequent use of drugs containing chloramphenicol may lead to contact sensitization, which is accompanied by the development of hypersensitivity reactions upon subsequent use of the drug externally or in the form of dosage forms for systemic use.
Symptoms of overdose with systemic absorption of benzocaine may include: drowsiness, anxiety, cardiac arrhythmias, agitation. In severe cases, convulsions, coma, decreased respiratory rate or respiratory failure. There are reports that the use of products containing benzocaine caused methemoglobinemia. Symptoms such as cyanosis of the skin, lips and nail beds, headache, dizziness, shortness of breath (difficulty breathing), weakness, tachycardia, which may occur during treatment, may indicate methemoglobinemia, which is potentially life-threatening and requires urgent medical intervention. Emergency care for overdose and the development of methemoglobinemia consists of intravenous administration of methylene blue.
Symptoms of overdose with systemic absorption of boric acid may include: nausea, vomiting, diarrhea, circulatory disorders and depression of the central nervous system, decreased body temperature, shock, coma, erythematous rash. In case of severe poisoning, measures are taken to maintain vital functions of the body, hemodialysis or peritoneal dialysis, blood exchange transfusion are performed. With prolonged use of the drug on large areas of the skin, symptoms of chronic intoxication may occur: tissue edema, exhaustion, stomatitis, eczema, menstrual disorders in women, anemia, convulsions, alopecia.
Symptoms of overdose require discontinuation of the drug and symptomatic treatment.
Adverse reactions
Local reactions: slight temporary (2–3 min) increase in discomfort in the anal area after administration of the drug.
On the part of the immune system: allergic reactions are possible, including angioedema, other signs of irritation not observed before treatment, skin rashes, itching, burning sensation, hyperemia, edema. Prolonged external use often leads to contact sensitization.
Gastrointestinal: possible urge to defecate, dyspeptic phenomena (nausea, vomiting, loose stools). In these cases, the use of the drug should be discontinued.
From the side of the hematopoietic system: leukopenia, thrombocytopenia, reticulocytopenia, decreased hemoglobin level in the blood.
Expiration date
2 years.
Storage conditions
Keep out of reach of children. Store in original packaging at a temperature of + 2 °C to + 8 °C.
Packaging
60 g in cylinders with continuous valves, equipped with nozzles and protective caps.
Vacation category
Without a prescription.
Producer
JSC "STOMA".
Location of the manufacturer and its business address
Ukraine, 61105, Kharkiv, Newton St., 3.
