Ornizol ® tablets are used for the following indications:
trichomoniasis (urinary tract infections in women and men caused by Trichomonas vaginalis); amebiasis (all intestinal infections caused by Entamoeba histolytica, including amoebic dysentery, all extraintestinal forms of amebiasis, especially amoebic liver abscess); giardiasis.
Composition
The active ingredient is ornidazole (one tablet contains 500 mg of ornidazole in terms of 100% substance).
Excipients: microcrystalline cellulose; povidone; talc; sodium starch glycolate (type A); lactose, monohydrate; calcium stearate, coating mixture "Opadry II White" (contains: hypromellose; lactose, monohydrate; titanium dioxide (E 171); triacetin; polyethylene glycol / macrogol).
Contraindication
Hypersensitivity to the drug or to other nitroimidazole derivatives; patients with CNS lesions (epilepsy, brain lesions, multiple sclerosis); pathological blood lesions or other hematological abnormalities.
Method of application
"Ornizol ®" should always be taken orally after meals.
Trichomoniasis
500 mg tablets are used in single or 5-day therapy regimens.
Since taking ornidazole can lead to reactions such as redness, numbness, fever, nausea and vomiting, as well as possible hypotension and tinnitus, alcohol should not be consumed for at least 3 days after taking the drug.
Recommended dosage:
single therapeutic dose: 3 tablets taken in the evening - daily dose (tablet weighing 500 mg); five-day therapy: one tablet in the morning, one tablet in the evening - daily dose (tablet weighing 500 mg).
To eliminate the possibility of re-infection, the sexual partner must undergo the same course of treatment.
The single daily dose for children is 25 mg/kg.
Amebiasis
Possible treatment regimens:
3-day course of treatment for patients with amoebic dysentery; 5-10-day course of treatment for all forms of amebiasis.
Recommended dosage regimen (daily dose):
3-day course of treatment: adults and children weighing more than 35 kg (500 mg tablet) - 3 tablets at a time in the evening; with a body weight of more than 60 kg - 4 tablets (two tablets in the morning and two tablets in the evening); children weighing up to 35 kg - 40 mg/kg of body weight, a single dose; 5-10-day course of treatment: adults and children weighing more than 35 kg (500 mg tablet) - two tablets (one tablet in the morning and one tablet in the evening); children weighing up to 35 kg - 25 mg/kg of body weight, a single dose.
Giardiasis
Recommended dosage regimen 1-2-day course of treatment:
adults and children weighing over 35 kg - 3 tablets at a time in the evening; children weighing up to 35 kg - 40 mg/kg, single dose.
Application features
Pregnant women
Ornidazole does not have a teratogenic or toxic effect on the fetus. Since controlled studies in pregnant women have not been conducted, the drug should be prescribed in early pregnancy or during breastfeeding only if there are absolute indications, if the possible benefit of using the drug for the mother outweighs the potential risk to the fetus / child.
Drivers
When using the drug "Ornizol ®" such manifestations as drowsiness, rigidity, dizziness, tremor, convulsions, impaired coordination, temporary loss of consciousness are possible. The possibility of such manifestations must be taken into account for patients who drive vehicles or work with other mechanisms.
Overdose
It manifests itself as an increase in symptoms of adverse reactions.
Treatment: no specific antidote is known, diazepam should be used in case of convulsions. Treatment is symptomatic.
Side effects
From the lymphatic system and hematopoietic system: manifestations of effects on the bone marrow, leukopenia, neutropenia.
Nervous system: drowsiness, headache, dizziness, tremor, rigidity, impaired coordination, ataxia, convulsions, fatigue, spatial disorientation, temporary loss of consciousness, confusion, agitation and peripheral neuropathy.
Gastrointestinal: taste disturbance, metallic taste in the mouth, coated tongue, nausea, vomiting, diarrhea, epigastric pain, dry mouth, loss of appetite.
From the hepatobiliary system: unknown - jaundice, impaired biochemical indicators of liver function, increased levels of liver enzymes; hepatotoxicity.
Immune system disorders: hypersensitivity reactions, including anaphylactic shock, angioedema.
Skin and subcutaneous tissue disorders: skin rash, urticaria, skin hyperemia, itching.
Infections and infestations: exacerbation of candidiasis.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C, out of the reach of children.
Shelf life - 4 years.
