Paracetamol Euro infusion solution is used for the following indications:
adults: short-term treatment of moderate pain, especially in the postoperative period; short-term treatment of hyperthermic reactions; children: symptomatic treatment of pain and hyperthermia after surgery.
Composition
The active substance is paracetamol (1 ml of solution contains 10 mg of paracetamol).
Excipients: glucose, monohydrate; acetic acid; sodium acetate, trihydrate; sodium citrate, dihydrate; water for injections.
Contraindication
hypersensitivity to paracetamol and other components of the drug; severe hepatocellular insufficiency; severe renal insufficiency; age up to one year.
Method of application
"Paracetamol Euro" is used for rapid relief of pain and/or hyperthermic syndrome when an exclusively intravenous route of administration of the drug is necessary.
When using the drug in children, before starting the infusion, the excess drug is withdrawn from the vial and the volume of solution corresponding to a single dose is left.
The duration of the infusion should be 15 minutes.
Adults and children weighing 50 kg or more
The maximum single dose is 1000 mg of paracetamol. The maximum daily dose is 4 g. The interval between administration of the drug should be at least 4 hours. Usually, one to four infusions are used during the first day from the onset of pain syndrome (postoperative period), if necessary, the duration of treatment can be increased, but it should not exceed 72 hours (3 days), the total number of infusions - no more than 12.
Children weighing from 33 kg to 50 kg
For 15 mg/kg paracetamol per injection, i.e. 1.5 ml/kg. The maximum daily dose should not exceed 60 mg/kg body weight. The minimum interval between doses should be 4 hours. The duration of treatment usually does not exceed 4 infusions during the day.
Children weighing from 10 kg to 33 kg
For 15 mg/kg paracetamol per injection, i.e. 1.5 ml/kg. The maximum daily dose should not exceed 60 mg/kg body weight. The minimum interval between doses should be 4 hours. The duration of treatment usually does not exceed 4 infusions during the day.
Application features
Pregnant women
There is no data on the negative impact of intravenous paracetamol on fetal development or fetotoxic effects. However, the benefit/risk ratio should be assessed before using the drug, and during use of the drug, the pregnant woman should be carefully monitored.
Paracetamol is able to penetrate into breast milk. Breastfeeding should be discontinued during treatment.
Children
Not prescribed for children under one year of age and weighing less than 10 kg.
Drivers
The drug does not affect the reaction speed when driving vehicles or other mechanisms.
Overdose
The risk of toxic effects of the drug increases in the elderly, children, patients with liver failure, in cases of chronic alcoholism, in the presence of alimentary dystrophy and in people with reduced enzymatic activity. In these cases, overdose can be fatal.
Symptoms appear within the first 24 hours and are manifested by nausea, vomiting, anorexia, pallor, abdominal pain. Overdose in adults can be with a single dose of 7.5 g or more, in children - 140 mg / kg body weight. In this case, liver cytolysis, liver failure, metabolic acidosis, encephalopathy develop, which can lead to coma and death of the patient. Within 12-48 hours, the level of hepatic transaminases (AST, ALT), lactate dehydrogenase, bilirubin increases and the level of prothrombin decreases. Clinical symptoms of liver damage appear after two days and reach a maximum after 4-6 days.
Treatment: administration of SH-group donors and precursors of glutathione-methionine synthesis 8-9 hours after overdose and N-acetylcysteine - 12 hours after. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed since its administration.
Side effects
From the cardiovascular system: rarely - arterial hypotension.
On the part of the liver: rarely - increased levels of hepatic transaminases.
From the blood: rarely - thrombocytopenia, leukopenia, neutropenia.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C, out of the reach of children.
Shelf life - 18 months. Opened solution cannot be stored.
