Instructions Permethrin spray 0.5% can 50 g
Composition
active ingredient: permethrin;
1 g of the drug contains 5 mg of permethrin;
Excipients: ethonium, benzalkonium chloride, ethanol (96%), purified water.
Dosage form
The solution is topical.
Main physicochemical properties: clear, colorless or slightly yellow liquid with a characteristic alcohol odor.
Pharmacotherapeutic group
Ectoparasite control products, including scabies mite control products, insecticides and repellents. Pyrethrins, including synthetic compounds. Permethrin.
ATX code P03A C04.
Pharmacological properties
Pharmacodynamics.
Contact insecticide, belonging to the group of synthetic pyrethroids. Has a pediculicidal effect, has a detrimental effect on nits, larvae and sexually mature forms of head and pubic lice. Disrupts the permeability of sodium channels in the membranes of insect nerve cells, inhibits the process of polarization (repolarization) of the nerve cell, which leads to a paralyzing effect.
Pharmacokinetics.
Less than 2% of the dose of permethrin is absorbed after dermal application. It is highly lipid soluble, and its toxicity is increased by organic solvents. Based on animal studies, permethrin binds to glucuronides, glycines, and sulfates in the liver. The half-life is several hours. Permethrin is rapidly hydrolyzed to inactive metabolites and is excreted primarily in the urine.
Clinical characteristics.
Indication
Pediculosis (head, pubic).
Contraindication
Hypersensitivity to permethrin and to the excipients of the drug. Violation of skin integrity, inflammatory processes and secondary skin infections.
Pregnancy or breastfeeding. Children under 3 years of age.
The use of Permethrin is not recommended for patients with bronchial asthma, obstructive bronchitis, including a history of it, due to the risk of bronchospasm when inhaling the drug.
Special safety measures.
Medical personnel working with Permethrin should wear protective gloves. Permethrin should only be used externally.
Treatment should be carried out in a well-ventilated area or outdoors. During treatment, Permethrin should be prevented from getting on the mucous membranes of the eyes, nose, mouth, and genitourinary organs. In case of accidental contact of Permethrin with mucous membranes, the latter should be washed with plenty of water, after treatment, wash hands thoroughly with soap and rinse mouth with running water.
To prevent reinfection, the entire family must be checked for pathogens, clothing, hats, scarves, bedding, combs, and hair of people who have been in contact with the patient must be disinfected.
Interaction with other medicinal products and other types of interactions
Not installed.
Use during pregnancy or breastfeeding
No studies have been conducted on the safety of Permethrin during pregnancy or breastfeeding, therefore, the drug should not be used during this period.
Ability to influence reaction speed when driving vehicles or other mechanisms
Not installed.
Method of administration and doses
Externally. Wet the hair well with the solution using a cotton swab, rubbing the medicine into the hair roots. After treatment, leave Permethrin on the hair for 10-40 minutes (the head can be covered with a scarf), then rinse thoroughly with warm running water with soap or shampoo and dry in the usual way. After washing the hair, comb it with a thick comb to remove dead parasites; if live lice are found, repeat the treatment before the next hair wash or after 7 days.
Permethrin consumption, depending on the thickness and length of the hair, ranges from 10 ml to 60 ml.
For pubic lice, moisten the pubic hair abundantly with undiluted solution using a cotton swab. After 30 minutes, wash the treated areas with soap and rinse thoroughly with water.
Children
Do not use in children under 3 years of age.
Overdose
In case of overdose, the symptoms listed in the "Side effects" section may be aggravated. In case of overdose, it is necessary to stop using Permethrin, wash the skin with plenty of warm water, and antihistamines may also be used. In case of poisoning due to inhalation of Permethrin vapors, treatment should begin by removing the patient to fresh air. If Permethrin gets into the eyes or on the skin, the affected areas should be washed with plenty of water.
In case of accidental ingestion of Permethrin, there is a high probability of spontaneous vomiting, therefore further administration of emetics is not recommended due to the risk of rapid development of convulsions and coma. Absorption of Permethrin can be prevented by gastric lavage and the use of activated charcoal or a laxative. Treatment is primarily supportive and includes monitoring the patient for allergic reactions.
Adverse reactions
Local effects: burning sensation, tingling or prickling, numbness of the skin, increased itching, erythema, pain, eczema.
Expiration date
3 years.
Storage conditions
Keep out of the reach of children. Store at a temperature not exceeding 25 °C.
Protect from falls, impacts, and exposure to direct sunlight.
Packaging
50 g in light-resistant glass bottles with funnel-shaped stoppers and lids.
Each bottle with a funnel-shaped stopper and caps and instructions for medical use in the state and Russian languages is placed in a cardboard pack.
Vacation category
Without a prescription.
Producer
JSC "Stoma", Ukraine.
Location of the manufacturer and its business address
Ukraine, 61105, Kharkiv, Newton St., 3.
