Quetiapine film-coated tablets 200 mg blister No. 30

Quetiapine tablets are indicated for the treatment of schizophrenia, treatment of bipolar disorders:

Composition

Active ingredient: quetiapine;

1 tablet contains 25 mg or 100 mg, or 200 mg or 300 mg of quetiapine (as quetiapine fumarate);

Excipients: lactose, microcrystalline cellulose, sodium starch (type A), povidone, calcium phosphate dihydrate dibasic, magnesium stearate;

Tablet coating 25 mg polyethylene glycol, titanium dioxide (E 171), hydroxypropylmethylcellulose, red iron oxide (E172), yellow iron oxide (E172);

Tablet coating 100 mg polyethylene glycol, titanium dioxide (E 171), hydroxypropylmethylcellulose, iron oxide yellow (E172);

Tablet coating 200 mg and 300 mg polyethylene glycol, hydroxypropylmethylcellulose, titanium dioxide (E 171), talc.

Contraindication

Hypersensitivity to the components of the drug.

Concomitant use of cytochrome P450 3A4 inhibitors, such as HIV protease inhibitors, azole antifungals, erythromycin, clarithromycin, and nefazodone.

Method of application

Apply to adults 2 times a day, regardless of meals.

Application features

Pregnant women

It should be prescribed only in cases where the expected benefit to the mother outweighs the possible risk to the fetus.

Children

Not applicable.

Drivers

Not applicable.

Overdose

In general, the symptoms and signs of overdose reported were due to an increase in the known pharmacological effects of the drug, such as drowsiness and sedation, tachycardia, hypotension and anticholinergic effects.

There is no specific antidote for quetiapine. In case of severe intoxication, the need for multi-directional measures should be considered and intensive care procedures are recommended, including the restoration and maintenance of airway patency, ensuring adequate oxygenation and ventilation of the lungs, monitoring and support of the cardiovascular system.

Side effects

The following adverse reactions were reported more frequently with quetiapine (10%): drowsiness, dizziness, dry mouth, headache, withdrawal syndrome, increased serum triglycerides, increased serum total cholesterol (predominantly LDL cholesterol), decreased HDL cholesterol, weight gain, decreased hemoglobin, and extrapyramidal symptoms.

Interaction

The drug should be prescribed with caution to patients receiving other drugs with anticholinergic (muscarinic) effects.

Although quetiapine primarily acts on the central nervous system (CNS), quetiapine should be used with caution in combination with other drugs with similar effects and with alcohol.

Concomitant use of cytochrome P450 3A4 inhibitors, such as HIV protease inhibitors, azole antifungals, erythromycin, clarithromycin, and nefazodone.

Storage conditions

Store in the original packaging at a temperature not exceeding 30 °C.

Keep out of reach of children.

Shelf life - 5 years.