Instructions for Regidron powder dosed package 18.9 g No. 20
Composition
active ingredients:
1 packet contains: potassium chloride 2.5 g; sodium chloride 3.5 g; sodium citrate 2.9 g; anhydrous glucose 10 g.
Dosage form
The powder is dosed.
Main physicochemical properties: white, odorless crystalline powder.
Pharmacotherapeutic group
Electrolyte preparations with carbohydrates. Salt formulations for oral rehydration.
ATX code A07C A.
Pharmacological properties
Pharmacodynamics
Rehydron solution is used to compensate for electrolyte and fluid loss during diarrhea and vomiting. Glucose promotes salt absorption, citrates help correct the balance in metabolic acidosis. The osmolarity of the Rehydron solution is 235-255 mOsm/l, the pH is slightly alkaline - 8.2.
The solution of the drug Regidron contains (per 1 liter of solution):
| Sodium chloride | 59.9 mmol |
| Potassium chloride | 33.5 mmol |
| Sodium citrate | 9.9 mmol |
| Glucose | 55.5 mmol |
| Na+ | 89.5 mmol |
| K+ | 33.5 mmol |
| Cl- | 93.4 mmol |
| Citrate ions | 9.9 mmol |
Compared to standard oral rehydration solutions recommended by the WHO, the osmolarity of Regidron is slightly lower (rehydration solutions with reduced osmolarity have been proven to be more effective) and the potassium content is higher (to accelerate the restoration of potassium levels).
Pharmacokinetics
The pharmacokinetics of water, electrolytes and glucose, which are part of the drug Regidron, correspond to the natural pharmacokinetics of these substances in the body.
Indication
Restoration of water and electrolyte balance, correction of acidosis in acute diarrhea with mild and moderate dehydration (e.g., loss of 3-9% of body weight in children), in heat injuries accompanied by impaired water and electrolyte metabolism. For prophylactic purposes: in heat and physical exertion leading to intense sweating.
Contraindication
Hypersensitivity to the components of the drug, severe dehydration, hemodynamic shock, uncontrollable vomiting, loss of consciousness, intestinal obstruction, ileus.
Interaction with other medicinal products and other types of interactions
There is no information on the interaction of the drug Regidron with other drugs. The pH of the drug solution is slightly alkaline, so it may affect drugs whose absorption depends on the pH of the intestinal contents. Also, the absorption of drugs may be changed in diarrhea, mainly those drugs that are absorbed in the small or large intestine, or in their enterohepatic circulation.
Application features
Severe dehydration (weight loss of more than 9% of body weight in children, anuria) should be treated first with intravenous rehydration agents. After this, Regidron may be prescribed for continued therapy.
The recommended doses of the drug should not be exceeded unless the patient's need for additional electrolyte administration is confirmed by laboratory tests.
The drug should be administered orally, using water to dissolve it. The contents of 1 packet of Regidron should be dissolved in 1 liter of water. Sugar should not be added to the solution. Food intake is possible immediately after rehydration. In case of vomiting, wait
10 minutes and let the solution be drunk slowly, in small sips.
If the dose is exceeded, the patient may develop hypernatremia.
Patients in whom dehydration has developed against the background of renal failure, diabetes mellitus or other chronic diseases that disrupt acid-base, electrolyte or carbohydrate balance require careful monitoring during therapy with Regidron and may require hospitalization.
Caution should be exercised when treating patients with liver disease, patients on a diet with a limited sodium or potassium content with Regidron. Diarrhea can significantly affect the fluid and glucose balance in patients with diabetes mellitus, renal failure or some other chronic diseases. Therefore, while symptoms of diarrhea persist, such patients require more careful monitoring with laboratory evaluations and in-hospital dehydration therapy.
Regidron should be used with caution in case of renal failure during oliguria or anuria, in case of parenteral rehydration therapy.
The drug should not be used in children under 6 months of age without consulting a doctor.
In infants, acute diarrhea can cause dehydration and electrolyte imbalances, leading to rapid deterioration of the patient's condition. All cases of diarrhea and dehydration in infants should be reported to a doctor as soon as possible.
the patient's mental state has changed (irritability, apathy, lethargy); the patient has slowed down his speech, becomes drowsy, quickly becomes exhausted and does not respond to questions; constant vomiting; the temperature rises above 39 °C; urine output stops; loose bloody stools appear; diarrhea lasts more than 2 days; severe abdominal pain; diarrhea suddenly stops, severe pain appears; treatment at home is unsuccessful or impossible.
Regidron contains potassium and sodium, which must be taken into account when using the solution in patients with impaired kidney function who are on a diet with controlled potassium or sodium intake.
Since the medicine contains glucose, patients with rare hereditary diseases such as glucose-galactose malabsorption should not take this medicine.
Ability to influence reaction speed when driving vehicles or other mechanisms
The drug does not affect the reaction speed when driving vehicles or other mechanisms.
Use during pregnancy or breastfeeding
The drug is approved for use in recommended doses during pregnancy or breastfeeding. Breastfeeding can be continued as long as necessary, even during oral rehydration, or it can be continued immediately after rehydration.
Method of administration and doses
Dissolve the powder from 1 sachet of Regidron in 1 liter of boiled water cooled to room temperature. No other components should be added to the solution, so as not to disrupt the effect of the drug. The solution should be taken orally or administered under the supervision of a physician through a nasogastric tube.
Before starting treatment, the patient should be weighed to determine body weight loss and the degree of dehydration.
Fatty foods and foods high in simple sugars should be avoided.
Therapy with Regidron should be started after the onset of diarrhea.
The finished solution should be taken in small sips after each loose bowel movement. Over 6-10 hours, the dose of the Regidron solution can be 30-60 ml/kg of body weight. Usually, the drug should be taken for no longer than 3-4 days, and the drug should be discontinued after the diarrhea has stopped. In case of nausea or vomiting, it is advisable to take the cooled solution in small repeated doses.
Rehydration: to correct dehydration, the drug should be taken during the first 6-10 hours in an amount that is twice the weight loss due to diarrhea, i.e. if the loss is 400 g, the amount of the drug is 800 ml. During therapy with Regidron, there is no need to use other fluids.
Further use: if diarrhea continues, after correction of dehydration, it is possible to take Regidron and other fluids within the next 24 hours according to the table:
| Body weight (kg) | Total liquid amount (ml) | Regidron (ml) | Water (ml) | Other liquids (ml) |
| 5 | 830 | 350 | 210 | 270 |
| 6 | 1000 | 420 | 250 | 330 |
| 7 | 1050 | 440 | 260 | 350 |
| 8 | 1100 | 460 | 280 | 360 |
| 9 | 1150 | 480 | 290 | 380 |
| 10 | 1200 | 500 | 300 | 400 |
| 12 | 1300 | 540 | 320 | 440 |
| 14 | 1400 | 580 | 350 | 470 |
| 16 | 1500 | 620 | 370 | 510 |
| 18 | 1600 | 660 | 400 | 540 |
| 20 | 1700 | 700 | 420 | 580 |
| 25 | 1800 | 750 | 450 | 600 |
| 30 | 1900 | 800 | 480 | 620 |
| 40 | 2100 | 900 | 540 | 660 |
| 50 | 2300 | 1000 | 600 | 700 |
| 70 | 2700 | 1200 | 720 | 780 |
Children
Regidron can be used in children. There are no restrictions on the age from which children can use this medicine.
Overdose
When administering a very large amount or a very concentrated solution of the drug Regidron, hypernatremia may occur. In patients with reduced kidney function, metabolic alkalosis and hyperkalemia may occur. Symptoms of hypernatremia include weakness, neuromuscular excitation, drowsiness, confusion, coma, and sometimes even respiratory arrest. Metabolic alkalosis may manifest itself in decreased lung ventilation, neuromuscular excitation, and tetanic convulsions.
In case of severe overdose with severe consequences, the administration of Regidron should be discontinued. A doctor's consultation is necessary. Correction of electrolyte and fluid balance should be carried out on the basis of laboratory test data.
Adverse reactions
When the recommended doses are observed, the development of adverse reactions is unlikely. The development of allergic reactions is potentially possible. In patients with normal renal function, the risk of hypernatremia or hyperhydration when using the drug Regidron is low. Vomiting may occur, indicating that the drug has been administered too quickly.
Expiration date
3 years.
Storage conditions
Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Store the prepared solution in a refrigerator at 2-8°C for 24 hours.
Packaging
18.9 g of powder per bag; 20 bags per carton.
Vacation category
Without a prescription.
Producer
Orion Corporation.
Location of the manufacturer and its business address
Orionintie 1, 02200 Espoo, Finland.
