Regulax picosulfate oral drops dropper bottle 20 ml

Pharmacological properties

Sodium picosulfate refers to contact laxatives that irritate the receptors of the intestinal mucosa. Activated in the colon under the action of bacterial sulfatases; the substance released stimulates the sensitive nerve endings of the intestinal mucosa, enhancing its motility. The laxative effect of sodium picosulfate is not accompanied by tenesmus and intestinal spasms. In infants, the effectiveness of sodium picosulfate may be insufficient due to the small amount of bacterial flora that produces sulfatases.

Regulax Picosulfate drops - a remedy that regulates bowel function, increasing the volume of feces and enhancing peristalsis (natural rhythmic movement), promotes timely, painless bowel movements. The laxative effect occurs after 10-12 hours.

Sodium picosulfate is absorbed in the small intestine only in limited quantities and has practically no systemic effect. After the breakdown of the complex sulfate ester by bacteria in the large intestine, a diphenol laxative is formed, which is partially absorbed and, after conjugation, is excreted in the bile.

A small part is excreted in the urine as a glucuronide; a large part is excreted in the feces as both free diphenol and picosulfate itself.

Indication

Intestinal atony, constipation (except spastic), caused by a change in the nature and diet, prolonged immobilization, fever, severe general condition, diseases of the cardiovascular system and metabolic disorders; used in pre- and postoperative periods, in obstetric and gynecological practice, to facilitate defecation in hemorrhoids, anal fissures, inoperable hernias, myocardial infarction, severe acute respiratory syndrome, to cleanse the intestines before instrumental examination.

Application

Regulax picosulfate drops are taken orally once, preferably in the evening. As a rule, the effect occurs after 10-12 hours. Adults and children over 12 years old are prescribed 13-26 drops (corresponds to 5-10 mg of sodium picosulfate monohydrate), children 4-12 years old - 6-12 drops (corresponds to 2.5 -5 mg of sodium picosulfate monohydrate).

The use of the drug should be short-term.

Contraindication

Hypersensitivity to the components of the drug. intestinal obstruction, constipation along with symptoms of intestinal obstruction (abdominal pain, nausea, vomiting, fever), peritonitis, acute inflammatory diseases of the abdominal organs, children under 4 years of age.

Side effects

With short-term use, side effects rarely develop. Sometimes abdominal pain, diarrhea, nausea may occur.

Long-term use of Regulax Picosulfate drops can lead to loss of water, potassium and other salts. This, in turn, can cause intestinal atony, cardiac disorders, and muscle weakness.

Special instructions

The drug Regulax picosulfate drops is intended for short-term use.

During pregnancy, the drug can only be used under strict indications and under the supervision of a doctor.

Breastfeeding should be discontinued during use of the drug.

The drug can be used for diabetes mellitus, as it contains a sugar substitute (1 ml of drops contains 0.03 CU).

The drug is used with caution after operations on the gastrointestinal tract, in case of dehydration.

Habituation has not been observed with prolonged use.

Interactions

Diuretics, adrenal cortex hormones when used simultaneously with the drug increase the risk of hypokalemia, arrhythmia and muscle weakness. The drug may enhance the toxic effects of cardiac glycosides. Irrational antibiotic therapy may reduce the effectiveness of the drug.

Overdose

It manifests itself as diarrhea, cramping abdominal pain. Replacement therapy is carried out, electrolyte loss is replenished.

Storage conditions

At a temperature of 15-25 °C.