Instructions Sargin oral solution 200 mg/ml sachet 5 ml No. 20
Composition
active ingredient: L-arginine aspartate;
1 ml of solution contains Arginine aspartate (L-arginine aspartate) - 200 mg;
excipients: sodium propyl parahydroxybenzoate (E 217), sodium methyl parahydroxybenzoate (E 219), sorbitol (E 420), sodium saccharin (E 954), grape flavoring, purified water.
Dosage form
Oral solution.
Main physicochemical properties: yellowish to yellow-brown liquid with a grape odor.
Pharmacotherapeutic group
Other cardiological drugs. Amino acids.
ATX code C01E.
Pharmacological properties
Pharmacodynamics
Sargin® has antihypoxic, cytoprotective, antioxidant, detoxification, membrane-stabilizing effects. It plays an important role in the processes of ammonia neutralization and stimulation of its excretion from the body, enhances the detoxification function of the liver. It has a hepatoprotective effect, positively affects the processes of energy supply in hepatocytes.
As a nitric oxide donor, Sargin® participates in the processes of energy supply of the body, reduces the activation and adhesion of leukocytes and platelets to the vascular endothelium, preventing the formation and development of atherosclerotic plaques, and is involved in the processes of fibrinogenolysis and spermatogenesis.
The drug has a moderate anabolic effect, stimulates the activity of the thymus gland, promotes insulin synthesis and regulates blood glucose levels during physical exertion, and helps correct acid-base balance.
Pharmacokinetics
Not studied.
Indication
Use in the complex therapy of atherosclerosis of the heart and brain vessels, arterial hypertension, atherosclerosis of peripheral vessels; diabetic angiopathy; chronic heart failure; hypercholesterolemia; chronic obstructive pulmonary diseases, pulmonary hypertension; asthenic conditions.
Contraindication
Hypersensitivity, severe renal impairment. Myocardial infarction (including history).
Interaction with other medicinal products and other types of interactions
When using arginine aspartate, it is necessary to take into account that the combined use of aminophylline with arginine may be accompanied by an increase in insulin levels in the blood, and spironolactone with arginine may be accompanied by an increase in potassium levels in the blood.
Arginine is incompatible with thiopental.
Application features
It should be used with caution in cases of electrolyte imbalance and kidney disease. When using the drug, it is necessary to adhere to a balanced sleep and rest regimen, and to avoid alcohol, nicotine, and psychostimulants. If symptoms of asthenia increase while taking the drug, treatment should be discontinued.
The drug should be used with caution in patients with angina pectoris.
Patients with hereditary fructose intolerance should not take the drug.
This medicine contains sorbitol (E 420). If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
The drug contains excipients such as sodium methyl parahydroxybenzoate (E 219) and sodium propyl parahydroxybenzoate (E 217), which may cause allergic reactions (possibly delayed).
This medicinal product contains less than 0.04 mmol (0.95 mg) sodium/dose (5 ml), i.e. essentially ‘sodium-free’.
Use during pregnancy or breastfeeding
The drug penetrates the placenta, so it can be used during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.
There are no data on the use of the drug during breastfeeding.
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Method of administration and doses
Use orally, take with meals. Adults with atherosclerosis of the heart and brain vessels, atherosclerosis of peripheral vessels, diabetic angiopathy - 5 ml (1 measuring spoon - 1 g of the drug) 3-8 times a day. With hypercholesterolemia, arterial hypertension - 5 ml 3-6 times a day. With chronic obstructive pulmonary diseases, pulmonary hypertension - 5 ml 3-6 times a day. With asthenic conditions - 5 ml 4-8 times a day. The maximum daily dose is 8 g. The duration of the course of treatment is 8-15 days; if necessary, the course of treatment should be repeated.
Children.
Do not use in patients under 18 years of age.
Overdose
Symptoms: hypersensitivity reactions, hypoglycemic states.
Treatment. If these symptoms occur, the drug should be discontinued. Gastric lavage and sorbents are indicated. There is no antidote. Symptomatic therapy.
Adverse reactions
Musculoskeletal system: joint pain.
On the part of the digestive tract: rarely - a feeling of mild discomfort in the stomach and intestines, nausea immediately after taking the drug, which disappear on their own.
Immune system disorders: hypersensitivity reactions, including bronchospasm.
Laboratory indicators: hyperkalemia.
Expiration date
The shelf life of the drug after first opening is 14 days.
Do not use the medicine after the expiry date stated on the packaging.
Storage conditions
Does not require special storage conditions.
Keep out of reach of children.
Incompatibility
Arginine is incompatible with thiopental.
Packaging
100 ml in a bottle. 1 bottle with a dosing spoon in a pack.
Vacation category
Without a prescription.
Producer
JSC "Farmak".
Address
Ukraine, 04080, Kyiv, Kyrylivska St., 74.
