Silibor 35 film-coated tablets 35 mg blister No. 30

Pharmacological properties

Silibor contains flavonoids (silybinin, silychristin, silydianin) from the fruits of milk thistle - silybum marianum (l.).

Pharmacodynamics. Hepatoprotective agent, the mechanism of action of which is due to antioxidant and membrane-stabilizing activity. Improves metabolism in hepatocytes: normalizes phospholipid metabolism, stimulates the synthesis of structural and functional proteins, RNA and glycogen. Prevents the penetration of hepatotoxic substances into liver cells and accelerates the processes of hepatocyte regeneration.

Pharmacokinetics. Slowly absorbed in the gastrointestinal tract (half-absorption period - 2.2 h), metabolized in the liver by conjugation. Up to 40% of silymarin excreted in the bile is reabsorbed and enters the enterohepatic circulation cycle. Excreted mainly with bile in the form of glucuronides and sulfates, to a lesser extent - with urine. Half-life - 6 h. Does not accumulate in the body.

Indication

Chronic hepatitis of various etiologies, cirrhosis of the liver (as part of complex therapy), conditions after acute infectious and toxic hepatitis, liver steatosis; prophylactic agent for prolonged professional intoxications and prolonged use of drugs that have a hepatotoxic effect.

Application

Take before meals, without chewing, with a small amount of water. Adults and children over 12 years of age are prescribed 70 mg 3 times a day. For patients with severe forms of the disease, the daily dose can be increased to 420 mg, divided into 3 doses, if necessary. Children aged 6-9 years are prescribed 70 mg 1 time a day, 9-12 years - 70 mg 2 times a day. Duration of treatment - 1 month; if necessary, it can be increased to 3 months. The course of treatment can be repeated after 1-2 months. As a prophylactic agent, it is prescribed in a daily dose of 70 mg 1-2 times a day. Duration of prophylactic administration - up to 1 month.

Contraindication

Hypersensitivity to the components of the drug, age up to 4 years.

Side effects

Possible dyspeptic phenomena (diarrhea) and allergic reactions (skin rashes, itching), increased diuresis. With long-term courses of taking the drug, an increase in existing disorders of the vestibular apparatus (dizziness) may be noted. In case of adverse reactions, the dose is reduced or the drug is canceled.

Special instructions

Use during pregnancy and breastfeeding. The drug can be used only under the supervision of a doctor and provided that the expected benefit to the mother outweighs the potential risk to the child. When taking the drug, an increase in diuresis may be noted, due to the slight diuretic effect characteristic of flavonoids.

Impact on the ability to drive vehicles and operate complex mechanisms. No effect.

Overdose

Cases of overdose with Siliboron have not been described. In case of overdose of the drug, vomiting should be induced, activated charcoal should be taken, and symptomatic therapy should be carried out.

Storage conditions

Store in a dry place protected from light at a temperature of 8-25 °C.