SK-SD streptokinase-streptodornase rectal suppositories 15000 IU + 1250 IU blister No. 6

Instructions for use SK-SD streptokinase-streptodornase rectal suppositories 15000 IU + 1250 IU blister No. 6

Composition

active ingredients: streptokinase, streptodornase;

1 suppository contains streptokinase 15,000 IU, streptodornase 1250 IU;

excipients: mineral oil, solid fat.

Dosage form

Rectal suppositories.

Main physical and chemical properties: suppositories of cylindrical-conical shape from white to beige color. On the cut, the presence of an air-porous rod and a hole-shaped cavity is allowed.

Pharmacotherapeutic group

Hematological agents. Enzymes. Combinations with streptokinase. ATX code B06A A55.

Pharmacological properties

Pharmacodynamics

The drug "SK-SD, streptokinase-streptodornase", suppositories, acts locally after rectal administration. Streptokinase acts as a fibrinolytic and dissolves fibrin and other clots. Streptodornase dissolves deoxyribonucleoproteins and deoxyribonucleoacids, as a result of which the viscosity of purulent exudates decreases and dead cells dissolve.

Pharmacokinetics

Streptokinase and streptodornase act locally on blood clots, purulent and necrotic parts of cells and tissues. The drug is administered rectally and is not absorbed into the bloodstream.

The streptokinase-plasminogen complex is gradually converted into polypeptides. The degradation products, together with other substrate fragments, are mechanically removed. Streptodornase, after DNA polymerization, is converted into a nucleotide mixture and is mechanically removed with parts of dead cells.

Indication

– Chronic inflammatory processes of the uterine appendages;

– postoperative infiltrative lesions of the pelvic organs;

– endometritis;

– hemorrhoids in acute and chronic course;

– pararectal abscesses and fistulas with extensive inflammatory infiltrate;

– purulent caudal cysts.

Contraindication

– Hypersensitivity to the active substances or excipients of the drug;

– the presence of a fresh wound, surgical suture or bleeding for up to 10 days (this may cause the sutures to loosen and, as a result, bleeding from the wound);

– simultaneous use with anticoagulants, which may lead to local bleeding;

– blood clotting disorders.

Interaction with other medicinal products and other types of interactions

The drug "SK-SD, streptokinase-streptodornase" is contraindicated for use with anticoagulants, as bleeding is possible.

Application features

The medicine may cause local irritation.

Use during pregnancy or breastfeeding

The effect of the drug "SK-SD, streptokinase-streptodornase" on fertility, pregnancy and during breastfeeding has not been studied.

Ability to influence reaction speed when driving vehicles or other mechanisms

Does not affect the ability to influence the reaction speed when driving vehicles or other mechanisms.

Method of administration and doses

Dosage

Course of treatment: 4–18 suppositories. Duration of course: 2–9 days.

The dosage is prescribed by the doctor according to the intensity of the inflammatory process.

In severe and chronic course of the disease:

– 1 suppository 3 times a day for the first 3 days;

– 1 suppository 2 times a day for the next 3 days;

– 1 suppository once a day for the next 3 days.

Course of treatment: 9 days, 18 suppositories.

With a moderately severe course of the disease:

– 1 suppository 2 times a day for the first 3 days;

– 1 suppository once a day for the next 4 days,

The course of treatment is 7 days, 10 suppositories.

With a mild course of the disease:

– 1 suppository 2 times a day for 2 days.

Course of treatment: 2 days, 4 suppositories.

In the absence of results or in the event of relapse, the doctor must determine the need for a second course of treatment.

Method of application

Rectal. Suppositories should be inserted deep into the rectum, after removing the suppository from the blister. Wash hands thoroughly before and after using the drug.

Children

The medicine is not prescribed for children.

Overdose

There are no data on overdose of streptokinase and streptodornase.

Adverse reactions

Sometimes the following may occur: local pain, swelling or minor bleeding, irritation, diarrhea, allergic reactions, and fever.

Expiration date

2 years.

Storage conditions

Store at 2–8°C in the original packaging. Do not freeze.

Keep out of reach of children.

Packaging

6 suppositories in a blister; 1, 2 or 3 blisters in a cardboard box.

Vacation category

According to the recipe.

Producer

Farmina Ltd.

Location of the manufacturer and address of its place of business

Lipska Street 44, 30-721, Krakow, Poland.