Instructions for use SK-SD Streptokinase-Streptodornase rectal suppositories 15000 IU/1250 IU No. 18
Composition
active ingredients: streptokinase, streptodornase;
1 suppository contains streptokinase 15,000 IU, streptodornase 1250 IU;
excipients: mineral oil, solid fat.
Dosage form
Rectal suppositories.
Main physical and chemical properties: suppositories of cylindrical-conical shape from white to beige color. On the cut, the presence of an air-porous rod and a hole-shaped cavity is allowed.
Pharmacotherapeutic group
Hematological agents. Enzymes. Combinations with streptokinase. ATX code B06A A55.
Pharmacological properties
Pharmacodynamics
The drug "SK-SD, streptokinase-streptodornase", suppositories, acts locally after rectal administration. Streptokinase acts as a fibrinolytic and dissolves fibrin and other clots. Streptodornase dissolves deoxyribonucleoproteins and deoxyribonucleoacids, as a result of which the viscosity of purulent exudates decreases and dead cells dissolve.
Pharmacokinetics
Streptokinase and streptodornase act locally on blood clots, purulent and necrotic parts of cells and tissues. The drug is administered rectally and is not absorbed into the bloodstream.
The streptokinase-plasminogen complex is gradually converted into polypeptides. The degradation products, together with other substrate fragments, are mechanically removed. Streptodornase, after DNA polymerization, is converted into a nucleotide mixture and is mechanically removed with parts of dead cells.
Indication
Chronic inflammatory processes of the uterine appendages; postoperative infiltrative lesions of the pelvic organs; endometritis; hemorrhoids in acute and chronic course; pararectal abscesses and fistulas with extensive inflammatory infiltrate; purulent caudal cysts.
Contraindication
Hypersensitivity to the active substances or excipients of the drug; presence of a fresh wound, surgical suture or bleeding for up to 10 days (this may cause loosening of the sutures and, as a result, bleeding from the wound); simultaneous use with anticoagulants, which may lead to local bleeding; blood clotting disorders.
Interaction with other medicinal products and other types of interactions
The drug "SK-SD, streptokinase-streptodornase" is contraindicated for use with anticoagulants, as bleeding is possible.
Application features
The medicine may cause local irritation.
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect the ability to influence the reaction speed when driving vehicles or other mechanisms.
Use during pregnancy or breastfeeding
The effect of the drug "SK-SD, streptokinase-streptodornase" on fertility, pregnancy and during breastfeeding has not been studied.
Method of administration and doses
Dosage
Course of treatment: 4–18 suppositories. Duration of course: 2–9 days.
The dosage is prescribed by the doctor according to the intensity of the inflammatory process.
In severe and chronic course of the disease:
1 suppository 3 times a day for the first 3 days; 1 suppository 2 times a day for the next 3 days; 1 suppository 1 time a day for the next 3 days.
Course of treatment: 9 days, 18 suppositories.
With a moderately severe course of the disease:
1 suppository 2 times a day for the first 3 days; 1 suppository 1 time a day for the next 4 days,
The course of treatment is 7 days, 10 suppositories.
With a mild course of the disease:
1 suppository 2 times a day for 2 days.
Course of treatment: 2 days, 4 suppositories.
In the absence of results or in the event of relapse, the doctor must determine the need for a second course of treatment.
Method of application
Rectal. Suppositories should be inserted deep into the rectum, after removing the suppository from the blister. Wash hands thoroughly before and after using the drug.
Children
The medicine is not prescribed for children.
Overdose
There are no data on overdose of streptokinase and streptodornase.
Adverse reactions
Sometimes the following may occur: local pain, swelling or minor bleeding, irritation, diarrhea, allergic reactions, and fever.
Expiration date
2 years.
Storage conditions
Store at 2–8°C in the original packaging. Do not freeze.
Keep out of reach of children.
Packaging
6 suppositories in a blister; 3 blisters in a cardboard box.
Vacation category
According to the recipe.
Producer
Farmina Ltd.
Location of the manufacturer and its business address
Lipska Street 44, 30-721, Krakow, Poland.
