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SODIUM CHLORIDE-DARNYTSYA solution for injection 9 mg/ml
Instruction
For medical use of the medicinal product
Composition:
Active ingredient: sodium chloride;
1 ml of solution contains 9 mg of sodium chloride;
excipient: water for injections.
Dosage form.
Solution for injection.
Main physicochemical properties: clear colorless liquid, salty taste.
Pharmacotherapeutic group.
Blood substitutes and perfusion solutions. electrolyte solutions. ATX code B05X A03.
Pharmacological properties.
Pharmacodynamics.
0.9% sodium chloride solution normalizes water-salt balance and eliminates fluid deficiency in the human body, which develops during dehydration or due to accumulation of extracellular fluid in the foci of major burns and injuries, during operations on the abdominal organs, peritonitis. The drug improves tissue perfusion, increases the effectiveness of blood transfusion measures in massive blood loss and severe forms of shock. It also has a detoxification effect due to a short-term increase in fluid volume, a decrease in the concentration of toxic products in the blood, and activation of diuresis.
Pharmacokinetics.
Rapidly excreted from the vascular system. The drug is in the vascular bed for a short time, after which it passes into the interstitial and intracellular sectors. After 1 hour, only about half of the injected solution remains in the vessels. Very quickly, salts and fluid begin to be excreted by the kidneys, increasing diuresis.
Clinical characteristics.
Indication.
Preparation of drug solutions for external and parenteral use; locally for washing wounds, nasal mucosa, as well as catheters and transfusion systems.
Contraindication.
Incompatibility of the main drug and the solvent. The drug should not be used for eye irrigation during ophthalmic operations.
Interaction with other drugs and other types of interactions.
Sodium chloride-Darnitsa is compatible with most medications, so it can be used to dissolve various medications - with the exception of those medications that are not compatible with sodium chloride as a solvent.
Application features.
Before dissolving the medicinal product, it should be checked whether it is possible to use sodium chloride solution to dissolve this medicinal product.
Use during pregnancy or breastfeeding.
The medicine can be used during pregnancy or breastfeeding.
The ability to influence the speed of reactions when driving vehicles or other mechanisms.
No effect.
Method of administration and doses.
The drug should be used as a solvent for parenteral administration of the main drug.
To wash wounds and mucous membranes, use the solution in sufficient quantities.
Children.
The medicine can be used in children.
Overdose.
If used correctly, it is unlikely.
Adverse reactions.
Not observed with proper use of the drug.
Expiration date.
5 years.
Storage conditions.
Store in the original packaging at a temperature not exceeding 25 °C. Do not freeze. Keep out of the reach of children.
Incompatibility.
It is determined by the drug, which should be diluted with sodium chloride solution.
Packaging.
5 ml in an ampoule; 5 ampoules in a contour blister pack; 2 contour blister packs in a pack;
10 ml in an ampoule; 5 ampoules in a contour blister pack; 2 contour blister packs in a pack.
Vacation category.
According to the recipe.
Producer.
Chao "Darnitsa Pharmaceutical Company".
Location of production and its address of place of business.
Ukraine, 02093, Kyiv, Boryspilska St., 13.
SODIUM CHLORIDE-DARNYTSYA solution for infusion 9 mg/ml
Instruction
For medical use of the medicinal product
Composition:
Active ingredient: sodium chloride;
1 ml of solution contains 9.0 mg of sodium chloride; ionic composition per 1 l of the medicinal product: Na + - 154 mmol, Cl ¯ - 154 mmol;
excipient: water for injections.
Dosage form.
Solution for infusion.
Main physicochemical properties: clear colorless liquid.
Pharmacotherapeutic group.
Blood substitutes and perfusion solutions. Electrolyte solutions. ATS code B05X A03.
Pharmacological properties.
Pharmacodynamics.
0.9% sodium chloride solution normalizes water-salt balance and eliminates fluid deficiency in the human body, which develops during dehydration or due to the accumulation of extracellular fluid in the foci of major burns and injuries, during operations on the abdominal organs, and peritonitis.
0.9% sodium chloride solution improves tissue perfusion, increases the effectiveness of blood transfusion measures in massive blood loss and severe forms of shock.
It also exhibits a detoxification effect due to a short-term increase in fluid volume, a decrease in the concentration of toxic products in the blood, and activation of diuresis.
Pharmacokinetics.
Rapidly excreted from the vascular system. The drug is retained in the vascular bed for a short time, after which it passes into the interstitial and intracellular sectors. After 1 hour, only about half of the injected solution remains in the vessels. Very quickly, salts and fluid begin to be excreted by the kidneys, increasing diuresis.
Clinical characteristics.
To fill the deficit of fluid in the body and in the complex of intensive care measures; as a solvent for other compatible drugs. can be used locally for washing wounds, nasal mucosa, as well as catheters and transfusion systems.
Contraindication.
Hyperhydration, hyperchloremia, hypernatremia, hyperchloremic acidosis, conditions associated with the risk of developing pulmonary edema.
The drug is not used for washing the eyes during ophthalmic operations.
Interaction with other drugs and other types of interactions.
0.9% sodium chloride solution is compatible with most drugs, therefore it is used to dissolve various drugs, except for those drugs that are incompatible with sodium chloride as a solvent.
Administration of 0.9% sodium chloride may lead to decreased lithium levels.
Application features.
With prolonged administration, especially in large volumes, monitor the level of electrolytes in plasma and urine, as well as diuresis.
It is administered with caution to patients with impaired renal excretory function, with decompensated heart defects, and with edematous-ascites syndrome in patients with liver cirrhosis.
Concomitant administration with corticosteroids or corticotropin requires constant monitoring of electrolyte levels in the blood.
Patients taking lithium should avoid too high or too low sodium intake. Monitoring of lithium blood levels is recommended.
In cases of shock and blood loss, blood transfusions, plasma transfusions, and plasma substitutes can be performed simultaneously with the use of 0.9% sodium chloride solution.
Use during pregnancy or breastfeeding.
The medicine can be used according to indications.
The ability to influence the reaction speed when driving vehicles or other mechanisms.
No effect.
Method of administration and doses.
It is administered intravenously, rectally, and externally.
Administered intravenously drip up to 3 liters or more of solution per day at a rate of 4-10 ml/kg/h, depending on the clinical situation and the level of fluid loss; administered orally; administered in enemas of 75-100 ml; used for washing wounds and mucous membranes.
Children.
Children with shock dehydration (without determining laboratory parameters) are administered 20-30 ml/kg. In the future, the dosage regimen is adjusted depending on laboratory parameters. The total daily dose depends on the water-electrolyte balance, etc.
Overdose.
May lead to hyperchloremic acidosis, increased potassium excretion, hyperhydration and hypervolemia, which may lead to heart failure. If symptoms of these conditions appear, the drug should be discontinued, the patient's condition assessed, and adequate care provided.
Adverse reactions.
Not observed with proper use of the drug.
When carrying out massive infusions, the development of hyperchloremic acidosis is possible.
Expiration date.
3 years.
Storage conditions.
Store in the original packaging at a temperature not exceeding 25 °C. Do not freeze.
Keep out of reach of children.
Packaging.
200 ml or 400 ml in bottles.
Vacation category.
According to the recipe.
Producer.
Chao "Darnitsa Pharmaceutical Company".
Location of the manufacturer and address of its place of business.
Ukraine, 02093, Kyiv, Boryspilska St., 13.
