Instructions Sodium chloride solution for infusion 0.9% PE bottle 100 ml
Composition
active ingredient: sodium chloride;
1 ml of solution contains 9.0 mg of sodium chloride;
ionic composition per 1 liter of the drug: Na+ – 154 mmol, Cl¯ – 154 mmol;
excipient: water for injections.
Dosage form
Solution for infusion.
Main physicochemical properties: clear colorless liquid.
Pharmacotherapeutic group
Blood substitutes and perfusion solutions. Electrolyte solutions. ATX code B05X A03.
Pharmacological properties
Pharmacodynamics.
0.9% sodium chloride solution normalizes water-salt balance and eliminates fluid deficiency in the human body, which develops during dehydration or due to the accumulation of extracellular fluid in the foci of major burns and injuries, during operations on the abdominal organs, and peritonitis.
0.9% sodium chloride solution improves tissue perfusion, increases the effectiveness of blood transfusion measures in massive blood loss and severe forms of shock.
It also exhibits a detoxification effect due to a short-term increase in fluid volume, a decrease in the concentration of toxic products in the blood, and activation of diuresis.
Pharmacokinetics.
Rapidly excreted from the vascular system. The drug is retained in the vascular bed for a short time, after which it passes into the interstitial and intracellular sectors. After 1 hour, only about half of the injected solution remains in the vessels. Very quickly, salts and fluid begin to be excreted by the kidneys, increasing diuresis.
Indication
To replenish the lack of fluid in the body and in the complex of intensive care measures; as a solvent for other compatible drugs. Can be used locally for washing wounds, nasal mucosa, as well as catheters and transfusion systems.
Contraindication
Hyperhydration, hyperchloremia, hypernatremia, hyperchloremic acidosis, conditions associated with the risk of developing pulmonary edema.
The drug is not used for washing the eyes during ophthalmic operations.
Interaction with other medicinal products and other types of interactions
0.9% sodium chloride solution is compatible with most medications, so it is used to dissolve various medications, except for those medications that are incompatible with sodium chloride as a solvent.
Administration of 0.9% sodium chloride may lead to a decrease in lithium levels.
Application features
With prolonged administration, especially in large volumes, monitor the level of electrolytes in plasma and urine, as well as diuresis.
It is administered with caution to patients with impaired renal excretory function, with decompensated heart defects, and with edematous-ascites syndrome in patients with liver cirrhosis.
Concomitant administration with corticosteroids or corticotropin requires constant monitoring of blood electrolyte levels.
Patients taking lithium should avoid very high or very low sodium intake. Monitoring of lithium blood levels is recommended.
In cases of shock and blood loss, blood transfusion, plasma transfusion, and plasma substitutes can be performed simultaneously with the use of 0.9% sodium chloride solution.
Use during pregnancy or breastfeeding
The medicine can be used according to indications.
Ability to influence reaction speed when driving vehicles or other mechanisms
No effect.
Method of administration and doses
It is administered intravenously, rectally, and externally.
Doses
Administered intravenously drip up to 3 liters or more of solution per day at a rate of 4–10 ml/kg/h, depending on the clinical situation and the level of fluid loss; administered orally; administered in enemas of 75–100 ml; used for washing wounds and mucous membranes.
Method of application
Do not insert the needle(s) into any areas of the polymer vial that are not intended for this purpose, but only into sterile ports!
To carry out infusion treatment, you must follow the following algorithm:
Remove the protective plastic cover with the first opening control (if any);
Tear off the safety valve(s) No. 1 as shown in Fig. 1 and 2 (the manufacturer may use different types and materials for safety valves).
Remove the cap from the needle and insert it into any of the special ports No. 2 of the infusion drug vial.
Another sterile port can be used to introduce other drugs into the infusion bottle or, in case of insufficient flow rate, for an air needle.
Hang the solution bottle using the special ring No. 3 located at the bottom of the bottle.
Children.
Children with shock dehydration (without determining laboratory parameters) are administered 20–30 ml/kg. In the future, the dosage regimen is adjusted depending on laboratory parameters. The total daily dose depends on the water-electrolyte balance, etc.
Overdose
May lead to hyperchloremic acidosis, increased potassium excretion, hyperhydration and hypervolemia, which may lead to heart failure. If symptoms of these conditions appear, the drug should be discontinued, the patient's condition should be assessed and adequate care provided.
Side effects
Not observed with correct use of the drug.
When performing massive infusions, the development of hyperchloremic acidosis is possible.
Expiration date
3 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 ° C. Do not freeze.
Keep out of reach of children.
Packaging
100 ml or 200 ml, or 250 ml, or 400 ml, or 500 ml in bottles.
100 ml in bottles, 40 bottles in boxes.
200 ml or 250 ml, or 400 ml, or 500 ml in bottles, 20 bottles in boxes.
Vacation category
According to the recipe.
Producer
PrJSC "Pharmaceutical Company "Darnitsa".
Address
Ukraine, 02093, Kyiv, Boryspilska St., 13.
