Strepsils with honey and lemon lozenges blister pack No. 24

Instructions for Strepsils with honey and lemon lozenges blister No. 24

Composition

active ingredients: 2,4-dichlorobenzyl alcohol, amylmetacresol;

1 lollipop contains: 2,4-dichlorobenzyl alcohol 1.2 mg, amylmetacresol 0.6 mg;

excipients: honey, peppermint oil, lemon oil, tartaric acid, quinoline yellow (E 104), sucrose solution, glucose solution.

Dosage form

Lollipops.

Main physicochemical properties: round, yellow lollipops with an "S" embossed on both sides.

Pharmacotherapeutic group

Drugs used in throat diseases. Antiseptics. Dichlorobenzyl alcohol. ATX code R02A A03.

Pharmacological properties

Pharmacodynamics

2,4-Dichlorobenzyl alcohol and amylmetacresol are antiseptics and have antibacterial (bactericidal and bacteriostatic), antifungal and antiviral properties, which have been demonstrated in vitro. When both active substances are combined in one medicinal product, a synergistic antibacterial effect is observed, which allows to reduce the dosage required for the combination. In vitro studies have demonstrated antibacterial activity of the drug against certain microorganisms that cause sore throat, such as Streptococcus pyogenes, Staphylococcus aureus, Haemophilus influenza and Moraxella catarrhalis, after 1 minute of contact. An overall reduction in the bacterial load in the oral cavity was also observed in one in vivo study. In vitro studies have also shown antiviral activity of amylmetacresol and 2,4-dichlorobenzyl alcohol, as well as combinations of these two substances, against enveloped viruses, including influenza A virus, parainfluenza virus, respiratory syncytial virus, cytomegalovirus, and coronavirus, after 1-2 minutes of contact.

Clinical trial data show that Strepsils Honey and Lemon lozenges relieve sore throat, reduce soreness and difficulty swallowing, with an onset of action of 5 minutes and a duration of action of up to 2 hours. Significantly greater relief compared to the use of lozenges without active ingredients was also demonstrated with treatment for up to 3 days. One study also showed that Strepsils Honey and Lemon lozenges significantly reduced post-operative sore throat and hoarseness 20 minutes and 24 hours after intubation. A study in children (aged 6-16 years) with acute and recurrent chronic sore throat demonstrated a reduction in subjective and objective signs of sore throat after 3 days of treatment with Strepsils Honey and Lemon lozenges.

Strepsils Honey and Lemon Lozenges contain lemon oil, peppermint oil, and honey, the drug has a softening effect that soothes a sore throat.

Pharmacokinetics

Dichlorobenzyl alcohol is metabolized in the liver to form hippuric acid, which is excreted in the urine. Data on the metabolism and excretion of amylmetacresol are not available.

Indication

Symptomatic treatment of infectious and inflammatory diseases of the oral cavity and pharynx.

Contraindication

Hypersensitivity to any component of the drug.

Interaction with other medicinal products and other types of interactions

There are no known interactions.

Application features

The indicated maximum dose should not be exceeded.

If symptoms persist for 3 days, you should consult a doctor for additional adjustment of the treatment regimen.

Patients with rare hereditary diseases accompanied by fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase insufficiency should not use this drug. Patients with diabetes should take into account that 1 lollipop contains approximately 2.6 g of sugar.

Ability to influence reaction speed when driving vehicles or other mechanisms

The effect on the ability to drive or operate other mechanisms is absent or insignificant.

Use during pregnancy or breastfeeding

Pregnancy: There are no or limited amount of data from the use of amylmetacresol and 2,4-dichlorobenzyl alcohol. As with all medicines, caution should be exercised when using this medicine during pregnancy and, if necessary, seek medical advice.

Breast-feeding: It is not known whether 2,4-dichlorobenzyl alcohol, amylmetacresol or metabolites are excreted in human milk. A risk to the newborn/infants cannot be excluded.

Fertility: There are no data on the effect on fertility.

Method of administration and doses

For oromucosal use.

Use the lowest effective dose necessary to relieve symptoms for the shortest period of time.

It is recommended for adults and children over 6 years of age to take 1 lollipop every 2-3 hours. The lollipop should be slowly sucked until completely dissolved. Do not use more than 12 lollipops in 24 hours. If symptoms do not improve or worsen within 3 days, consult a doctor.

No dose adjustment is necessary for elderly patients.

Given the dosage form, the drug is contraindicated in children under 6 years of age.

Overdose

In the unlikely event of overdose, serious side effects are not expected. Some gastrointestinal discomfort may occur. Treatment is symptomatic.

Adverse reactions

The following adverse reactions have been observed with short-term use of 2,4-dichlorobenzyl alcohol and amylmetacresol at non-prescription doses. Other adverse reactions may occur with chronic disease treatment and long-term use.

Adverse reactions are classified by system organ class and frequency. The frequency is defined as follows: very common: ≥1/10; common: ≥1/100 and <1/10; uncommon: ≥1/1,000 and <1/100; rare: ≥1/10,000 and <1/1,000; very rare: <1/10,000; not known (cannot be estimated from the available data). Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.

From the immune system.

Uncommon: hypersensitivity reactions including urticaria.

From the respiratory tract and mediastinal organs.

Uncommon: pharyngeal oedema (swelling of the throat).

From the digestive tract.

Uncommon: oral discomfort (burning sensation in the mouth), throat irritation (burning sensation in the throat), oral paraesthesia (tingling sensation in the mouth), oral oedema. Rare: glossodynia (tongue pain). Very rare: dyspepsia, nausea, stomatitis. Not known: abdominal pain.

On the skin and subcutaneous tissue.

Not known: skin rash, itching, erythema.

Expiration date

2 years.

Storage conditions

Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Packaging

12 lollipops in a blister, 2 blisters in a cardboard box.

Vacation category

Without a prescription.

Producer

Reckitt Benckiser Healthcare International Limited.

Location of the manufacturer and its business address

Nottingham site, Thane Road, Nottingham, NG90 2DB, United Kingdom.