Instructions for use Synthomycin vaginal suppositories 0.25 g strip No. 10
Composition
active ingredient: chloramphenicol;
1 suppository contains 250 mg (0.25 g) of synthomycin;
excipient: solid fat.
Dosage form
Vaginal suppositories.
Main physicochemical properties: suppositories are white or white with a yellowish or creamy tint.
Pharmacotherapeutic group
Antimicrobial and antiseptic agents used in gynecology. Antibiotics. ATX code G01A A05.
Pharmacological properties
Pharmacodynamics
The active ingredient of the drug is chloramphenicol - a broad-spectrum antibiotic that has high antibacterial activity against pathogens of various forms of purulent-inflammatory processes. Chloramphenicol is a bacteriostatic antibiotic, it disrupts the process of protein synthesis in the microbial cell (having good lipophilicity, it penetrates the cell membrane of bacteria and reversibly binds to the 50S subunit of bacterial ribosomes, as a result, the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis). Active against most strains of gram-positive and gram-negative microorganisms, pathogens of purulent, intestinal infections, meningococcal infection: Escherichia coli, Shigella dysenteria, Shigella flexneri, Shigella boydii spp., Shigella sonnei, Salmonella spp. (including Salmonella typhi, Salmonella paratyphi), Staphylococcus spp., Streptococcus spp., (including Streptococcus pneumoniae), Neisseria meningitidis, Neuseria gonorrhoeae, some strains of Proteus spp., Burkholderia pseudomallei, Rickettsia spp., Treponema spp., Leptospira spp., Chlamydia spp., (including Chlamydia trachomatis), Coxiella burnetii, Ehrlichia canis, Bacteroides fragilis, Klebsiella pneumoniae, Hemophilus influenzae. Not effective against acid-fast bacteria (including Mycobacterium tuberculosis), anaerobes, methicillin-resistant strains of staphylococci, Acinetobacter, Enterobacter, Serratia marcescens, indole-positive strains of Proteus shh., Preudomonas aeruginosa spp., protozoa, fungi.
Resistance of microorganisms to chloramphenicol develops slowly.
Pharmacokinetics
It acts locally, penetrates well into the uterine tissues. The half-life is 3-5 hours. It is excreted in the urine in unchanged form and as metabolites, and is partially excreted in the feces.
Indication
Bacterial gynecological infections (vaginitis, cervicitis) caused by microorganisms sensitive to synthomycin.
Prevention of purulent-inflammatory diseases in gynecology; before invasive procedures: abortions, gynecological surgeries (diathermocoagulation of the cervix, hysterography), before and after the installation of an intrauterine device.
Contraindication
Hypersensitivity to the components of the drug. Psoriasis. Eczema. Fungal diseases of the vagina. Suppression of bone marrow hematopoiesis.
Interaction with other medicinal products and other types of interactions
It should not be administered simultaneously with drugs that inhibit hematopoiesis (sulfanilamides, pyrazolone derivatives, cytostatics).
Application features
With prolonged use, genital candidiasis develops. During treatment, systematic monitoring of peripheral blood composition is necessary; if leukopenia occurs, the drug must be discontinued.
Use during pregnancy or breastfeeding
Do not use during pregnancy or breastfeeding.
Ability to influence reaction speed when driving vehicles or other mechanisms
No tests have been conducted to study the effect of suppositories on the ability to drive vehicles and other mechanisms.
Method of administration and doses
Apply to adult women. Having previously freed the suppository from the contour shell, insert it as deeply as possible into the vagina. The patient should lie on her back. Apply 1 suppository 2-3 times a day. The maximum daily dose is 4 suppositories. The course of treatment is 5-7 days.
Children
The drug should not be used in children.
Overdose
Not described.
Adverse reactions
On the part of the immune system: allergic reactions, local irritation or itching are possible.
Gastrointestinal: dyspeptic phenomena (nausea, vomiting, loose stools).
From the hematopoietic system: leukopenia, thrombocytopenia, reticulocytopenia, decreased hemoglobin level in the blood.
In these cases, the use of the drug should be discontinued.
Expiration date
2 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
5 suppositories in strips. 2 strips in a cardboard pack.
Vacation category
According to the recipe.
Producer
PJSC "Monpharm".
Location of the manufacturer and its business address
Ukraine, 19100, Cherkasy region, Monastyryshche, Zavodska st., 8.
