Teopek tablets 300 mg blister No. 50

Pharmacological properties

Teopek contains theophylline as the active ingredient and has characteristic pharmacological properties - it has a stimulating effect on the central nervous system, enhances the contractile activity of the heart muscle, slightly dilates the coronary, as well as renal and other peripheral vessels, stimulates the respiratory center, moderately increases diuresis, inhibits platelet aggregation and the release of allergy mediators. The most important effect of the drug is bronchodilator. The mechanism of action is associated with the inhibition of phosphodiesterase and an increase in the content of cAMP in smooth muscle cells. The drug affects the intracellular distribution of calcium, reduces the release of histamine and leukotrienes from mast cells, inhibits the synthesis and activity of prostaglandins, increases the release of endogenous catecholamines. Due to the increase in the motor activity of the ciliated epithelium of the trachea and bronchi, the stimulating effect on the respiratory center and bronchodilator action, the drug improves alveolar ventilation.

The combination of theophylline with a composite polymer carrier provides a prolonged effect of the drug and a therapeutic concentration of theophylline in the blood serum when taking the drug 2 times a day, and also promotes the dosed release of the active substance in the digestive tract.

The maximum concentration of theophylline in the blood plasma is noted 3-6 hours after taking the drug inside. The time during which theophylline is determined in the blood plasma is 12-24 hours. The therapeutic concentration of theophylline in the blood plasma is 15 μg/ml. It is metabolized in the liver. The values of the half-life are very variable. 10% of the dose of the drug is excreted unchanged in the urine. The excretion of theophylline when taking Teopek tablets is increased in congestive heart failure, cirrhosis of the liver, and in smokers.

Indication

Teopek is prescribed to adults as a bronchodilator for various forms of bronchospasm, including asthma, chronic obstructive bronchitis, and pulmonary emphysema.

Application

Inside after meals, washed down with water. The tablet can be divided in half, but cannot be crushed, including chewing and dissolving in water.

In the first 1-2 days, the drug is prescribed at 0.15 g (1/2 tablet) 1-2 times a day with an interval between doses of 12-24 hours. In the following days, the single dose is increased to 0.3 g 2 times a day.

Duration of treatment - 2-3 months. However, it should be noted that the optimal doses and duration of drug administration must be selected individually, focusing on the nature of the disease, concomitant pathological processes, and the nature of complex therapy.

Contraindication

Hypersensitivity to the drug, hyperthyroidism, acute myocardial infarction, subaortic stenosis, extrasystole, epilepsy and other convulsive states, pregnancy and breastfeeding. The drug should be used with caution in gastric and duodenal ulcers. The drug is contraindicated in children under 14 years of age.

Side effects

Dizziness, headache, tachycardia, anxiety, sleep disturbances, anorexia, nausea, vomiting, abdominal pain are possible. In these cases, the dose of the drug is reduced or the drug is discontinued.

The development of side effects is more likely in coronary insufficiency, a tendency to tachycardia, epileptic seizures, chronic gastritis and colitis, and liver failure.

Special instructions

The drug should be prescribed with caution to patients with coronary artery disease, severe ag, impaired renal and/or hepatic function. The safety and efficacy of the drug during pregnancy and breastfeeding have not been established. There are no clinical data on the use of Teopek, a prolonged-release theophylline drug, for the treatment of children.

Interactions

Teopek is incompatible with anticonvulsants and barbiturates, ephedrine, methylxanthines, hormonal contraceptives, macrolide antibiotics, furosemide, propranolol, verapamil. Most of these drugs, due to the increase in the concentration of theophylline in the blood, can enhance the side effects of the latter, and barbiturates reduce its concentration in the blood.

Overdose

To date, there have been no reports of overdose with the drug Teopek.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C. Shelf life - 4 years.