Instructions for Thioretin A free ophthalmic solution 10 ml
Composition
Per 100 ml (ml):
α-Lipoic acid 0.1 g (g), L-proline 0.0752 g (g), L-glycine 0.1 g (g), L-lysine hydrochloride 0.014 g (g), L-leucine 0.0108 g (g), hydroxypropylmethylcellulose (hypromellose) 0.3 g (g), TRIS (hydroxymethylaminomethanetromethamine) 0.15 g (g), sodium tetraborate 0.08 g (g), sodium chloride 0.325 g (g), boric acid 1.04 g (g), water for injection.
Isotonic sterile ophthalmic solution with pH 7.0-7.4. Preservative-free.
Antioxidant. Metabolic drug.
General properties
α-Lipoic acid is a powerful antioxidant and chelator, activates carbohydrate metabolism, plays a key role in the energy metabolism of glucose, increases ATP synthesis. Inhibits the processes of gluconeogenesis and ketogenesis. Directly inactivates any free radicals, protects the lens from oxidation, preserves its transparency. Reduces the oxidation of lipids of cell membranes, especially in the nerve cells of the cornea, which allows to preserve its sensitivity. Increases endogenous antioxidant potential. Improves endothelial function. Has high bioavailability, is quickly and completely absorbed.
Amino acids in TIORETIN® A free provide substrates for new cell divisions and extracellular matrix synthesis. In particular, lysine and leucine are of fundamental importance for the structural stability of collagen in the stroma. Amino acids improve the trophism of the eye surface and prevent inflammatory and irritant reactions.
L-proline is one of the components of collagen protein – the basis of all tissues in the human body. It maintains the connective tissues of the eye sclera, cornea and blood vessels in a normal state.
L-glycine is a central neurotransmitter of inhibitory action, improves metabolic processes. Enhances the production of GABA. Has a positive effect on muscular dystrophies.
L-lysine is involved in collagen synthesis, namely in the formation of collagen fibrils, which is important for corneal healing. It has anti-inflammatory, anti-edematous, analgesic effects, increases vascular tone and phagocyte function, activates cellular and humoral immunity, and the processes of biosynthesis of amino acids, their precursors and metabolites.
L-leucine is an essential amino acid that participates in protein synthesis, completes the regeneration process, and is responsible for corneal transparency.
Boric acid - provides an antiseptic effect, has buffering properties and is used as a pH regulator in ophthalmic solutions.
Indications for use
Diabetic retinopathy.
Macular dystrophy.
Prevention of cataract progression.
Angiopathies and neuropathies of various genesis.
Method of administration and doses
Adults: 1 drop in the conjunctival sac 2-3 times a day.
Children: 1 drop 2-3 times a day under the supervision of a doctor. There are no age restrictions if the solution is prescribed by a doctor.
Side effects
May cause mild, short-term burning and blurred vision. In case of any prolonged adverse reaction, discontinue use of the solution and consult a doctor.
Contraindication
Hypersensitivity to any components of the product or other chemically related substances.
Reservation
The solution is intended for external ophthalmic use.
The solution is sterile until the vial is opened.
Do not use the solution if the vial is damaged.
To prevent contamination of the solution, close the bottle tightly after use and do not touch the tip of the dispenser to your eye or other objects.
If the medical device is used simultaneously with other ophthalmic drugs, a doctor should be consulted.
Contact lenses must be removed before using the solution.
Storage conditions
Store at a temperature not exceeding 25°C out of the reach of children.
Packaging
1 bottle of 10 ml (ml).
Expiration date
2 years.
From the moment of first application of the solution, the product can be used for no more than 3 months.
Do not use the product after the expiry date stated on the bottle label.
Producer
Fidia Farmaceutici S.p.A., Via Ponte della Fabbrica 3/A, 35031, Abano Terme (PD), Italy
Fidia Farmaceutici SpA., Via Ponte della Fabbrica, 3/A, 35031, Abano Terme (PD), Italy
Authorized representative of the manufacturer in Ukraine: LLC "S.A.F.PHARMA", Sobornosti Avenue, 7-A, office 514, 02160 Kyiv, Ukraine
