Troxegel gel 2% tube 40 g

Pharmacological properties

Pharmacodynamics. Troxerutin has angioprotective and phlebotonizing effect. Troxerutin accumulates selectively in the endothelial layer of veins, penetrates deeply into the subendothelial layer of the venous wall, and the concentration will be higher than in other tissues. The drug prevents damage to cell membranes caused by oxidation. The antioxidant effect is manifested in the reduction and elimination of the oxidative properties of oxygen, inhibition of lipid peroxidation, protection of the vascular endothelium from the oxidative action of hydroxyl radicals. Troxerutin reduces the increased permeability of capillaries and increases venous tone.

The cytoprotective effect is manifested in the inhibition of neutrophil activation and adhesion, reduction of erythrocyte aggregation and increased resistance of erythrocytes to deformation, and reduction of the release of inflammatory mediators.

The drug increases venous-arterial reflux, prolongs venous filling time, reduces blood flow to the skin (in the supine position), and improves microcirculation and microvascular perfusion.

The action of the drug is aimed at reducing the intensity of pain, improving trophism and eliminating various pathological disorders associated with venous insufficiency.

Pharmacokinetics. Due to the dosage form of the drug Troxegel, it ensures complete absorption of the active substance through the stratum corneum of the epidermis and penetration into the blood vessels in the subcutaneous tissue.

Indication

For symptomatic treatment of: venous insufficiency, pre-varicose and varicose syndrome, superficial thrombophlebitis, phlebitis and post-phlebitic conditions; for complex treatment of hemorrhoidal disease; edema and pain in injuries and varicose veins; muscle cramps (convulsive twitching of the calf muscles).

Application

The gel is applied to the affected area in a uniform thin layer in the morning and evening, rubbing in with light massage movements until the drug is completely absorbed. Does not leave greasy stains on clothes. The dosage and duration of use of the drug is determined by the doctor depending on the severity and course of the disease.

Contraindication

Hypersensitivity to troxerutin or any other excipient of the drug. Troxegel should not be applied to mucous membranes, open wounds and eczematous skin areas.

Side effects

In isolated cases, hypersensitivity reactions may occur, including skin irritation, erythema, pruritus, skin rash, dermatitis, angioedema. These symptoms usually disappear after discontinuation of the drug.

Special instructions

Prolonged use may lead to the development of hypersensitivity!

Benzalkonium chloride may cause skin reactions. Patients with severe renal impairment are not recommended to use the drug for a long time. If the severity of the symptoms of the disease does not decrease while taking the drug, you should consult a doctor.

Use during pregnancy and breastfeeding. There are no clinical data on the use of the drug during pregnancy and breastfeeding. Therefore, it is permissible only as prescribed by a doctor, who will determine the benefit to the woman / risk to the fetus (child).

Children. There are no contraindications for the use of the drug in children.

The ability to influence the reaction speed when driving vehicles or working with other mechanisms. Does not affect.

Interactions

Enhances the effect of ascorbic acid on the structure and permeability of the vascular wall.

Overdose

With local application, cases of overdose have not been registered. In case of accidental ingestion of a large amount of the drug, it is necessary to take general measures to eliminate it: induce vomiting, apply symptomatic treatment. If indicated, peritoneal dialysis is prescribed.

Storage conditions

In the original packaging at a temperature not exceeding 25 °C.