Instructions for use Troxerutin-Darnitsa gel 20 mg/g tube 30 g
Composition
active ingredient: troxerutin;
1 g of gel contains 20 mg of troxerutin;
Excipients: methyl parahydroxybenzoate (E 218), propylene glycol, carbomer 980, trometamol, disodium edetate, purified water.
Dosage form
Gel.
Main physical and chemical properties: transparent yellow gel with a faint characteristic odor. It should be homogeneous in appearance.
Pharmacotherapeutic group
Angioprotectors. Capillary stabilizing agents. Troxerutin. ATX code C05C A04.
Pharmacological properties
Pharmacodynamics.
Troxerutin-Darnitsa has an angioprotective and phlebotonizing effect.
The main site of drug accumulation is the endothelial layer of venules. The drug penetrates deeply into the subendothelial layer of the venous wall, where its concentration is higher than in neighboring tissues.
The drug prevents damage to cell membranes caused by oxidation. The antioxidant effect is manifested in the reduction and elimination of the oxidative properties of oxygen, inhibition of lipid peroxidation, protection of the vascular endothelium from the oxidative action of hydroxyl radicals. Troxerutin-Darnitsa reduces increased capillary permeability and increases venous tone.
The cytoprotective effect is manifested in the inhibition of neutrophil activation and adhesion, reduction of erythrocyte aggregation and increase of erythrocyte resistance to deformation, reduction of the release of inflammatory mediators.
The drug increases venous-arterial reflux, prolongs venous filling time, reduces blood flow to the skin (in the supine position), and improves microcirculation and microvascular perfusion.
The action of the drug is aimed at reducing swelling, pain, improving trophism and eliminating various pathological disorders associated with venous insufficiency.
Pharmacokinetics.
When applying the drug Troxerutin-Darnitsa to the affected area, the active substance quickly penetrates through the epidermis, after 30 minutes it is found in the dermis, and after 2-5 hours in the subcutaneous fat.
Indication
For symptomatic treatment of: venous insufficiency, pre-varicose and varicose syndrome, superficial thrombophlebitis, phlebitis and post-phlebitic conditions; for complex treatment of hemorrhoidal disease; edema and pain in injuries and varicose veins; muscle cramps (convulsive contraction of the calf muscles).
Contraindication
Hypersensitivity to troxerutin or to the components of the drug.
Interaction with other medicinal products and other types of interactions
Enhances the capillary protective effect of ascorbic acid.
Application features
Do not apply the gel to open wounds, eczematous skin, eyes and mucous membranes. Prolonged use may cause hypersensitivity.
Patients with severe renal impairment are not recommended to use the drug for a long time.
If the severity of the symptoms of the disease does not decrease when using the medicine, you should consult a doctor.
Use during pregnancy or breastfeeding
There is no data on the negative effects of the drug when used during pregnancy or breastfeeding, therefore its use is permissible only as prescribed by a doctor, who will determine the benefit-risk ratio for the woman/fetus (child).
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Method of administration and doses
Externally: the gel is applied in the morning and evening to the skin of the affected area, lightly rubbing with light movements until the drug is completely absorbed. In severe conditions, combination therapy with troxerutin capsules is recommended. In chronic venous insufficiency, combination therapy should be used until the symptoms disappear completely. The dosage and duration of treatment are determined by the doctor individually, taking into account the severity and course of the disease.
Children.
There are no contraindications for the use of the drug in children.
Overdose
No cases of overdose have been registered with topical application. In case of accidental ingestion of a large amount of the drug, general measures should be taken to eliminate the drug: induce vomiting, use symptomatic treatment. If indicated, use peritoneal dialysis.
Side effects
When using Troxerutin-Darnitsa gel, the following side effects may very rarely occur:
from the immune system: angioedema;
Skin and subcutaneous tissue disorders: skin irritation, redness, erythema, itching, skin rashes, dermatitis.
These symptoms usually disappear quickly after discontinuation of the medicinal product. This medicinal product contains methyl parahydroxybenzoate (E 218), which may cause allergic reactions (possibly delayed).
Expiration date
3 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 ° C. Do not freeze. Keep out of the reach of children.
Packaging
30 g or 50 g in a tube, 1 tube in a pack.
Vacation category
Without a prescription.
Producer
PrJSC "Pharmaceutical Company "Darnitsa".
Address
Ukraine, 02093, Kyiv, Boryspilska St., 13.
