Instructions Troxerutin gel 2% tube 35 g
Composition
active ingredient: 1 g of gel contains troxerutin – 20 mg;
Excipients: methyl parahydroxybenzoate (E 218), carbomer, triethanolamine, disodium edetate, purified water.
Dosage form
Gel.
Main physicochemical properties: light yellow or yellow gel, transparent, of uniform consistency.
Pharmacotherapeutic group
Angioprotectors. Capillary stabilizing agents. Troxerutin.
ATX code C05C A04.
Pharmacological properties
Pharmacodynamics.
Troxerutin has angioprotective and phlebotonizing effect. Troxerutin accumulates selectively in the endothelial layer of veins, penetrates deeply into the subendothelial layer of the venous wall, and the concentration is higher than in neighboring tissues.
The drug prevents damage to cell membranes caused by oxidation. The antioxidant effect is manifested in the reduction and elimination of the oxidative properties of oxygen, inhibition of lipid peroxidation, protection of the vascular endothelium from the oxidative action of hydroxyl radicals. Troxerutin reduces increased capillary permeability and increases venous tone. The cytoprotective effect is manifested in the inhibition of neutrophil activation and adhesion, reduction of erythrocyte aggregation and increase of erythrocyte resistance to deformation, reduction of the release of inflammatory mediators.
The drug increases the venous-arterial reflex, prolongs venous filling time, reduces blood flow to the skin (in the supine position), and improves microcirculation and microvascular perfusion.
The action of the drug is aimed at reducing pain, improving trophism, and eliminating various pathological disorders associated with venous insufficiency.
Pharmacokinetics.
Due to the dosage form of the drug, Troxerutin ensures complete absorption of the active substance through the stratum corneum of the epidermis and penetration into the blood vessels in the subcutaneous tissue.
Indication
Troxerutin is used for the symptomatic treatment of the following diseases:
- venous insufficiency;
- prevaricose and varicose syndrome;
- superficial thrombophlebitis, phlebitis and post-phlebitic conditions;
- complex treatment of hemorrhoidal disease;
- swelling and pain due to injuries and varicose veins;
- muscle cramps (convulsive contraction of the calf muscles).
Contraindication
Hypersensitivity to troxerutin or any of the excipients of the drug. Troxerutin should not be applied to mucous membranes, open wounds and eczematous skin areas.
Special safety measures.
Prolonged use may cause hypersensitivity!
Patients with severe renal impairment are not recommended to use the drug for a long time. If the severity of the symptoms of the disease does not decrease during the use of the drug, you should consult a doctor.
Interaction with other medicinal products and other types of interactions
Enhances the effect of ascorbic acid on the structure and permeability of the vascular wall.
Use during pregnancy or breastfeeding
There are no clinical data on the use of the drug during pregnancy or breastfeeding. Therefore, use is permissible only as prescribed by a doctor, who will determine the benefit-risk ratio for the woman/the fetus (child).
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Method of administration and doses
The gel should be applied to the affected area in an even thin layer in the morning and evening, rubbing in with light massage movements until the drug is completely absorbed.
In chronic venous insufficiency, use combination therapy until symptoms disappear completely.
The dosage and duration of use of the drug are determined by the doctor, taking into account the severity and course of the disease.
Children
There are no contraindications for the use of the drug in children.
Overdose
No cases of overdose have been registered with topical application. In case of accidental ingestion of a large amount of the drug, general measures should be taken to eliminate the drug: induce vomiting, use symptomatic treatment. If indicated, peritoneal dialysis should be used.
Adverse reactions
In isolated cases, hypersensitivity reactions may occur, including skin irritation, erythema, pruritus, skin rash, dermatitis, angioedema. These symptoms usually disappear after discontinuation of the drug. The drug contains methyl parahydroxybenzoate (E 218), which may cause allergic reactions (possibly delayed).
Expiration date
2 years.
Do not use after the expiry date stated on the packaging.
Storage conditions
Store in original packaging at a temperature not exceeding 25 0C.
Keep out of reach of children.
Packaging
35 g of gel in tubes No. 1; in a cardboard pack.
Vacation category
Without a prescription.
Producer
Location of the manufacturer and its business address
61010, Ukraine, Kharkiv, 1 Hordienkivska St.
