Instructions Troxerutin gel 2% tube 40 g
Composition
active ingredient: troxerutin;
1 g of gel contains 20 mg of troxerutin;
Excipients: carbomer, triethanolamine, disodium edetate, methyl parahydroxybenzoate (E 218), propylene glycol, purified water.
Dosage form
Gel 2%.
Main physicochemical properties: gel from yellow to light brown in color, transparent or slightly opalescent, with a faint characteristic odor, of uniform consistency.
Pharmacotherapeutic group
Angioprotectors. Capillary stabilizing agents. Bioflavonoids. Troxerutin. ATC code C05C A04.
Pharmacological properties
Pharmacodynamics.
The drug Troxerutin, gel 2%, is a mixture of bioflavonoids, which contains not less than 95% troxerutin. Troxerutin accumulates selectively in the endothelial layer of venules, penetrates deeply into the subendothelial layer of the venous wall, and the concentration is higher than in neighboring tissues. The drug prevents damage to cell membranes caused by oxidation.
The antioxidant effect is manifested in the reduction and elimination of the oxidative properties of oxygen, inhibition of lipid peroxidation, protection of the vascular endothelium from the oxidative action of hydroxyl radicals. Troxerutin reduces the increased permeability of capillaries and has a venotonic effect. The cytoprotective effect is the result of inhibition of neutrophil activation and adhesion, reduction of erythrocyte aggregation and increase of erythrocyte resistance to deformation, reduction of the release of inflammatory mediators.
Increases venous-arterial reflux, prolongs venous refill time, improves microcirculation and microvascular perfusion.
The action of the drug Troxerutin, 2% gel, is aimed at reducing swelling, pain, improving trophism and eliminating various pathological disorders associated with venous insufficiency.
Pharmacokinetics.
After topical application of Troxerutin gel, the active ingredient is easily released from the water-soluble gel base and penetrates the dermis after approximately 30 minutes, and into the subcutaneous fatty tissue after 2-5 hours.
Indication
Troxerutin, 2% gel, is used for the symptomatic treatment of the following diseases:
- venous insufficiency;
- prevaricose and varicose syndrome;
- superficial thrombophlebitis, phlebitis and post-phlebitic conditions;
- complex treatment of hemorrhoidal disease;
- muscle cramps (convulsive contraction of the calf muscles).
Contraindication
Hypersensitivity to troxerutin or to any of the excipients of the medicinal product. Troxerutin, 2% gel, should not be applied to mucous membranes, open wounds and eczematous skin areas.
Interaction with other medicinal products and other types of interactions
The drug enhances the effect of ascorbic acid on strengthening the structure and reducing the permeability of the vascular wall.
Application features
Hypersensitivity reactions are more common in patients with skin and/or allergic diseases.
Patients with severe renal impairment are not recommended to use the drug for a long time.
If the severity of the symptoms of the disease does not decrease when using the medicine, you should consult a doctor.
Use during pregnancy or breastfeeding.
There is no data on the negative effects of the drug when used during pregnancy or breastfeeding. However, the use of Troxerutin gel in the first trimester of pregnancy is not recommended.
The ability to influence the reaction speed when driving vehicles or other mechanisms.
Does not affect.
Method of administration and doses.
For skin use only.
Apply the gel to the affected area with an even thin layer 2 times a day (morning and evening), rubbing in with light massage movements until the medicine is completely absorbed. If necessary, you can apply a tight or elastic bandage. In chronic venous insufficiency, use combination therapy until the symptoms disappear completely.
The dosage and duration of use of the drug is determined by the doctor, taking into account the severity and course of the disease.
Children.
There are no contraindications for the use of the drug in children.
Overdose
No cases of overdose have been reported with topical application. In case of accidental ingestion of a large amount of the drug, general measures should be taken to remove the drug (e.g. induce vomiting) and symptomatic treatment should be administered. If necessary, peritoneal dialysis should be performed.
Adverse reactions
When using Troxerutin gel, skin irritation or allergic reactions, including redness, itching, skin rash, dermatitis, angioedema, may very rarely occur. Usually, these symptoms quickly disappear after discontinuation of the drug.
Expiration date
3 years.
The shelf life after first opening the tube is 6 months.
Storage conditions
Store at a temperature not exceeding 25 ° C. Do not freeze! Keep out of the reach of children.
Packaging
40 g or 100 g in tubes. One tube in a cardboard pack.
Vacation category
Without a prescription.
Manufacturer/applicant.
"Ternofarm" LLC.
Location of the manufacturer and address of its place of business / location of the applicant.
Ukraine, 46010, Ternopil, Fabrychna St., 4.
Phone/fax: (0352) 521-444, www.ternopharm.com.ua
