Instructions for Validol-Lubnypharm tablets No. 100
Composition
active ingredient: 1 tablet contains a solution of menthol in menthyl ester of isovaleric acid – 60 mg;
excipients: refined granulated sugar, calcium stearate.
Dosage form
Pills.
Main physical and chemical properties: solid, regular, round cylinders, the upper and lower surfaces of which are flat, the edges of the surfaces are beveled, with a dividing line, white or white with a yellowish tinge of color, with a characteristic menthol odor and a cooling taste. Gray inclusions and a powdery coating are allowed on the surface of the tablets.
Pharmacotherapeutic group
Combined cardiological drugs. ATX code C01E X.
Pharmacological properties
Pharmacodynamics
The drug has a calming effect on the central nervous system, and also causes a moderate reflex vasodilator (coronarolytic) effect by reflex irritation of sensitive nerve ("cold") receptors of the oral mucosa. Stimulation of receptors is accompanied by induction of the release of endorphins, enkephalins, dynorphins and other opioid peptides, which play an important role in reducing pain, normalizing vascular permeability and regulating other important mechanisms of the functioning of the cardiovascular and nervous systems. Under the influence of the drug, physiologically active compounds are released - histamine, kinins, etc.
Pharmacokinetics
When administered sublingually, the drug is absorbed from the oral mucosa. The therapeutic effect occurs after approximately 5 minutes.
After absorption, the drug is biotransformed in the liver and excreted in the urine in the form of glucuronides.
Indication
Mild angina attacks, neuroses, hysteria, sea and air sickness (symptomatic therapy); headache associated with taking nitrates.
Contraindication
Hypersensitivity to the components of the drug. Severe arterial hypotension, acute myocardial infarction.
Interaction with other medicinal products and other types of interactions
Reduces the severity of headaches caused by taking nitrates. Potentiation of sedative and antihypertensive effects is possible with simultaneous use with other psychotropic and antihypertensive drugs, opioid analgesics, anesthetics and alcohol.
Application features
In cases where pain in the heart area does not go away after taking the drug, it is necessary to consult a doctor to rule out acute coronary syndrome.
The drug contains sugar, which should be taken into account by patients with diabetes.
Use during pregnancy or breastfeeding
The use of the drug during pregnancy or breastfeeding is possible if, in the opinion of the doctor, the expected positive effect for the mother outweighs the potential risk to the fetus/child.
Ability to influence reaction speed when driving vehicles or other mechanisms
Caution is required in the first hours after taking the drug when driving vehicles or performing work that requires increased attention, as dizziness, drowsiness, and decreased psychomotor speed are possible.
Method of administration and doses
Keep the tablets in the mouth (under the tongue) until completely dissolved. A single dose for adults is 1-2 tablets; daily dose is 2-4 tablets.
If necessary, the daily dose can be increased. The maximum daily dose is 600 mg.
The duration of treatment is up to 7 days.
Children
There is no experience in using the drug to treat children.
Overdose.
Symptoms: headache, nausea, agitation, cardiac dysfunction, decreased blood pressure, central nervous system depression.
Treatment: drug withdrawal and symptomatic treatment.
Adverse reactions
Abdominal discomfort; hypersensitivity reactions including angioedema, urticaria, pruritus, rash.
With prolonged use, mild nausea, lacrimation, dizziness, short-term arterial hypotension, and drowsiness may occasionally occur, which quickly resolve on their own.
Expiration date
2 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
6 or 10 tablets in blisters; 10 tablets in a blister; 1 or 10 blisters in a cardboard pack.
Vacation category
Without a prescription.
Producer
JSC "Lubnypharm".
Location of the manufacturer and its business address
Ukraine, 37500, Poltava region, Lubny, Barvinkova st., 16.
