Vancomycin-Pharmex lyophilized powder for solution for infusion 500 mg vial No. 1

Lyophilisate for preparation of solution for infusions Vancomycin - Farmex is used to treat infections caused by gram-positive microorganisms that are sensitive to the drug, including in patients with a history of allergy to penicillins and cephalosporins:

Composition

Active ingredient: vancomycin;

1 vial contains vancomycin hydrochloride equivalent to vancomycin 500 mg or 1000 mg;

Excipients: sodium hydroxide / diluted hydrochloric acid (possible presence due to the need for pH correction).

Contraindication

Hypersensitivity to vancomycin or to any other component of the drug.

Method of application

Vancomycin should be administered intravenously for the treatment of life-threatening infections. It should never be administered as a bolus injection or intramuscularly due to pain and possible necrosis at the injection site.

Reactions to the administration of the drug may depend on both the concentration of the solution and the rate of its administration. For the treatment of adults, it is recommended that the concentration during administration does not exceed 5 mg/ml, and the rate of administration does not exceed 10 mg/min. For individual patients who need to limit the amount of fluid administered, the drug can be administered with a concentration of up to 10 mg/ml, but the rate of administration should not exceed 10 mg/min. A high concentration of the administered drug increases the risk of adverse reactions.

The duration of treatment depends on the therapeutic indications for which the drug is used.

Application features

Pregnant women

The use of vancomycin in the first trimester of pregnancy is contraindicated. The appointment of vancomycin in the second and third trimesters of pregnancy is possible only for vital indications, when the expected benefit to the mother outweighs the risk to the fetus, while it is necessary to monitor the concentration of vancomycin in the blood serum.

Children

The drug can be used in children immediately after birth.

Drivers

During treatment with the drug, the ability to concentrate may decrease, which should be taken into account when driving a car or performing work that requires increased attention.

Overdose

Overdose is characterized by increased severity of side effects.

Treatment aimed at maintaining adequate filtration is recommended.

Vancomycin is poorly dialyzed. Excess vancomycin should be removed by hemofiltration and hemodialysis using polysulfone membranes.

No specific antidote is known.

Side effects

During or shortly after rapid administration of the drug, in isolated cases, anaphylactic reactions (hypotension, shortness of breath, dyspnea, urticaria or itching) and cardiac disorders (heart failure up to cardiac arrest) may occur. Rapid administration of the drug may also cause flushing of the upper body, pain or spasms of the chest and back muscles. These reactions usually resolve within 20 minutes, but may persist for several hours. Such reactions are practically non-existent with slow administration of the drug over 60 minutes.

Interaction

When vancomycin is administered during or immediately after surgery, the effects of muscle relaxants, such as succinylcholine, may be increased or prolonged.

Vancomycin should not be mixed with aminophylline or fluorouracil preparations, as the properties of vancomycin may be significantly weakened over time.

Medications that reduce intestinal peristalsis are contraindicated in pseudomembranous colitis.

Storage conditions

Store in the original packaging at a temperature not exceeding 25 °C.

Keep out of reach of children.

Shelf life - 3 years.