Pharmacological properties
Troxerutin is a drug with p-vitamin activity and a pronounced angioprotective effect. The drug reduces vascular tissue permeability and capillary fragility, promotes normalization and improvement of tissue trophism, reduces stagnant phenomena in veins and paravenous areas, exhibits anti-edematous and anti-inflammatory effects, increases the tone of smooth muscles of venous blood vessels; participates in redox processes; stabilizes the activity of hyaluronic acid in cell membranes, blocking the activity of hyaluronidase; increases the density of the vascular wall, reduces exudation of the liquid part of the plasma and diapedesis of formed blood elements. By reducing the manifestations of exudative inflammation in the vessels, troxerutin limits the adhesion of platelets to the surface of the vascular wall. After taking the capsule inside, the drug is well absorbed in the gastrointestinal tract. Cmax of the active substance in plasma is noted on average 2 hours after ingestion. It penetrates the blood-brain barrier well. It is metabolized in the liver to form several metabolites. It is partially excreted unchanged in the urine and bile.
Indication
capsules:
chronic venous insufficiency with the following manifestations: edema, trophic skin lesions, including leg ulcers; after surgical interventions in connection with varicose veins; varicose veins, including during pregnancy (II and III trimesters), superficial thrombophlebitis, phlebitis, periphlebitis, post-phlebitic conditions, post-thrombotic syndrome; hemorrhoids; in the complex treatment of diabetic retinopathy; paresthesias and cramps of the lower extremities at night and upon awakening; post-traumatic edema and hematomas.
gel:
prevention and treatment of varicose veins; pain and swelling of the extremities due to venous insufficiency; trophic disorders and ulcers in chronic venous insufficiency; thrombosis, thrombophlebitis; post-phlebitic conditions; closed injuries (including sports injuries).
Application
Capsules. Venorutinol is taken orally during meals, 1 capsule 2 times a day (morning and evening). Maintenance therapy - 1 capsule per day. Sometimes the desired effect is observed after using a dose of 600 mg (2 capsules) per day.
Gelatin capsules should be swallowed without chewing.
The duration of treatment is determined by the severity of the disease. Usually the course of treatment is 3-4 weeks.
Gel. The drug is used externally. The gel is applied in a thin layer in the morning and evening to the affected areas with light massage movements until it is completely absorbed into the skin. The course of treatment depends on the severity of the disease and can last up to 20 days.
Contraindication
Capsules.
hypersensitivity to troxerutin and/or any component of the drug; gastric and duodenal ulcer, chronic gastritis (in the acute phase); children's age.
Gel.
hypersensitivity to the components of the drug; age up to 14 years.
Side effects
Capsules. When using Venorutinol capsules, adverse reactions rarely occur.
Gastrointestinal side effects include nausea, vomiting, abdominal pain, diarrhea, and dyspepsia. In rare cases, erosive-ulcerative lesions of the digestive tract may occur.
Possible skin allergic reactions - urticaria, itching; rarely - headache, facial flushing, sleep disturbances.
Gel. In some cases, local hypersensitivity reactions occur - urticaria, dermatitis, eczema. Most of these manifestations quickly disappear after discontinuation of the drug.
Special instructions
Capsules. The drug is prescribed with caution to patients with severe liver and gallbladder diseases. Long-term use of venorutinol is not recommended for patients with severe renal dysfunction.
Venorutinol is used during meals, given that it irritates the gastric mucosa.
The drug contains lactose, therefore patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use this medicine.
Patients with lower extremity edema caused by heart, kidney, or liver disease should not use the drug, as it is not effective in these conditions.
Gel. Do not apply to damaged skin, avoid contact with eyes and mucous membranes. Can be applied under an occlusive dressing.
Use during pregnancy and breastfeeding.
Should not be used in the first 3 months of pregnancy.
In the II and III trimesters of pregnancy and during breastfeeding, the drug may be used under the supervision of a physician if the expected benefit to the mother outweighs the potential risk to the fetus/child.
If the drug is used in breastfeeding women, breastfeeding is recommended to be discontinued.
Children: The efficacy and safety of the drug in children have not been studied.
Ability to influence the reaction rate when driving vehicles or working with other mechanisms. There is no data on the ability of the drug to influence the reaction rate when driving vehicles or working with other mechanisms.
Interactions
Capsules. The drug enhances the effect of ascorbic acid in strengthening the structure and reducing the permeability of the vascular wall.
Capsules. Symptoms of side effects may increase (nausea, diarrhea, dyspepsia, abdominal pain and headache, sleep disturbances, skin allergic reactions).
Treatment is symptomatic. Stop taking the drug, induce vomiting or wash the stomach. If necessary, peritoneal dialysis can be prescribed.
Storage conditions
Capsules. in original packaging at a temperature not exceeding 25 °C.
Gel. In a dry place protected from light at a temperature of 15-25 °C.
