Viagra odt orodispersible tablets 50 mg blister No. 2




Viagra ODT orodispersible tablets are recommended for use in men with erectile dysfunction, which is defined as the inability to achieve or maintain an erection of the penis necessary for successful sexual intercourse. Sexual arousal is required for Viagra ODT to be effective.
Composition
Active ingredient: sildenafil;
1 tablet contains 70.225 mg of sildenafil citrate, which is equivalent to sildenafil 50 mg;
Excipients: ludiflash (lure (E 421), crospovidone, polyvinyl acetate, povidone), croscarmellose sodium, microcrystalline cellulose, hydrophobic silicon dioxide, sucralose (E 955), indigo aluminum lake 30-36% (E 132), sweet taste enhancer, special natural component, lemon flavor, magnesium stearate.
Contraindication
Hypersensitivity to the active substance or to any of the excipients. Concomitant use with nitric oxide donors (such as amyl nitrite) or nitrates in any form is contraindicated, as sildenafil is known to affect the nitric oxide/cyclic guanosine monophosphate (cGMP) pathway and potentiate the hypotensive effect of nitrates. Concomitant use of phosphodiesterase-5 inhibitors (including sildenafil) with guanylate cyclase stimulators such as riociguat is contraindicated, as it may lead to symptomatic hypotension. Conditions in which sexual activity is not recommended (e.g. severe cardiovascular disorders such as unstable angina or severe heart failure). Loss of vision in one eye due to non-arteritic anterior ischemic optic neuropathy, regardless of whether this pathology is associated with previous use of phosphodiesterase-5 inhibitors or not. The presence of the following diseases: severe liver dysfunction, arterial hypotension (blood pressure below 90/50 mm Hg). Recent stroke or myocardial infarction and known hereditary degenerative retinal diseases such as retinitis pigmentosa (a small number of such patients have genetic disorders of the PDE of the retina), since the safety of sildenafil has not been studied in the case of such diseases.Method of application
The drug is administered orally.
The drug should be used immediately after removing the tablet from the blister. The tablet should be placed on the tongue, allowed to disintegrate, and then swallowed. The drug can be taken with or without water.
If a dose of 100 mg is required, the second tablet should be taken only after the first tablet has completely disintegrated.
It is recommended to use the drug on an empty stomach, since when the drug is used together with fatty food, there is a significant delay in absorption compared to taking the tablets on an empty stomach.
Application features
Pregnant women
Not intended for use by women.
Children
The drug is indicated for use by persons under the age of 18.
Drivers
With caution.
Overdose
The use of sildenafil at a dose of 200 mg did not lead to increased efficacy, but caused an increase in the number of cases of adverse reactions (headache, flushing, dizziness, dyspepsia, nasal congestion, visual disturbances).
In case of overdose, usual supportive measures should be applied as necessary. Acceleration of sildenafil clearance during hemodialysis is unlikely due to the high degree of binding of the drug to plasma proteins and the lack of elimination of sildenafil in the urine.
Side effects
The most commonly reported adverse reactions were headache, flushing, dyspepsia, nasal congestion, back pain, dizziness, nausea, hot flashes, visual disturbances, cyanopsia and blurred vision.
Interaction
Sildenafil is metabolized primarily by the cytochrome P450 (CYP) isoform 3A4 (major pathway) and isoform 2C9 (minor pathway). Therefore, inhibitors of these isoenzymes may decrease sildenafil clearance, and inducers of these isoenzymes may increase sildenafil clearance.
Storage conditions
Keep out of reach of children.
Store in original packaging to protect from moisture.
Shelf life - 3 years.
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