Soft capsules "Videoin" are used for the following indications:
prevention of rickets, including in premature newborns; prevention of vitamin D3 deficiency in high-risk patients who do not have absorption disorders; prevention of vitamin D3 deficiency in malabsorption; treatment of rickets and osteomalacia; maintenance therapy of osteoporosis.
Composition
The active substance is cholecalciferol (one capsule contains 25 mcg of cholecalciferol (vitamin D3 - 1000 IU)).
Excipients: α-tocopherol acetate, medium chain triglycerides.
Capsule shell: gelatin, glycerin.
Contraindication
Hypersensitivity to the components of the drug, hypercalcemia and/or hypercalciuria, idiopathic hypercalcemia of newborns, hypervitaminosis D, sarcoidosis, renal failure, urolithiasis, nephrolithiasis, tuberculosis. Pseudohypoparathyroidism (the need for vitamin D may be lower than during the period of normal sensitivity to the vitamin).
Method of application
The medicine should be administered orally.
Adults and older children (if able to swallow the capsule) should take the drug orally before or during meals, swallowing the capsule whole, with sufficient water.
For children from the second week of life or adults and older children (if swallowing is not possible), squeeze the contents of the capsule into a spoon (container) with liquid (milk, fruit juice) or other food.
If the contents of the capsule are added to a food bottle or plate, it is necessary to ensure that the food is completely consumed, otherwise it is not possible to guarantee the intake of the entire dose of the drug. The drug should be added to food immediately before consumption.
Application scheme (with the possibility of releasing liquid from the capsule)
Squeeze the contents of the capsule into a previously prepared clean spoon (container). To extract the contents of the capsule into a clean spoon (container) to collect the liquid contents, wash and dry your hands thoroughly.
With two fingers of one hand, take the capsule by the tail (for "fish") or the neck (for "bottles") and press so that the contents pass into the body of the capsule.
With two fingers of the other hand, slightly stretch and tightly squeeze the neck of the capsule. Slowly twist the tail or neck until it breaks off. Watch the neck so that the contents do not splash out when unscrewing the tail or neck.
After depressurizing the capsule, squeeze the contents as much as possible into a previously prepared clean spoon (container).
Recommended dosages
Prevention of rickets: the recommended dose is one capsule of 12.5 mcg (500 IU of vitamin D3) per day.
Prevention of rickets in premature newborns: the dose is determined by the doctor. The total recommended dose is one capsule of 25 mcg (1000 IU of vitamin D3) per day.
Prevention of vitamin D3 deficiency in high-risk patients without malabsorption: the recommended dose is one 12.5 mcg capsule (500 IU vitamin D3) per day.
Prevention of vitamin D3 deficiency in malabsorption: the dose is determined individually by the doctor. The total recommended dose is 3-5 capsules of 25 mcg (3000-5000 IU of vitamin D3) per day.
Treatment of rickets and osteomalacia: the dose is determined by the doctor individually, depending on the course and severity of the disease. The total recommended dose for the treatment of vitamin D3 deficiency for infants and children is 1-5 capsules of 25 mcg (1000-5000 IU of vitamin D3) per day.
Treatment lasts for a year.
Maintenance therapy for osteoporosis: the recommended dose is one capsule of 25 mcg (1000 IU of vitamin D3) per day.
Duration of use
The duration of treatment depends on the course and severity of the disease and is determined by the doctor individually.
Treatment of rickets and osteomalacia caused by vitamin D3 deficiency lasts for one year.
Children are prescribed the drug for the prevention of rickets, starting from the second week of life until the end of the first year of life. During the second year of life, further use of the drug may be necessary, especially in winter.
When using doses exceeding 1000 IU of vitamin D3 per day, as well as during continuous or long-term treatment, the level of creatinine in the blood and the level of calcium in the blood serum and urine should be regularly monitored. If necessary, the dose should be adjusted depending on the concentration of calcium in the blood serum.
Application features
Pregnant women
The drug should be used with caution in pregnant and breastfeeding women.
Children
The drug is used in children from the second week of life.
Drivers
There are no reports that the drug affects the ability to drive or use other mechanisms. However, it is recommended to exercise special caution when driving or operating other mechanisms, given the possibility of developing adverse reactions from the nervous system.
Overdose
In case of overdose, the following effects may develop: muscle weakness, loss of appetite, nausea, vomiting, constipation, polydipsia, polyuria, drowsiness, photosensitivity, pancreatitis, rhinorrhea, hyperthermia, decreased libido, conjunctivitis, hypercholesterolemia, increased transaminase activity, arterial hypertension, cardiac arrhythmia and uremia. Common symptoms are: pain in muscles and joints, headache, weight loss. Renal dysfunction develops with albuminuria, erythrocyturia and polyuria, increased potassium loss, hyposthenuria, nocturia and moderate increase in blood pressure.
In severe cases, corneal clouding is possible, less often - swelling of the optic nerve papilla, inflammation of the iris up to the development of cataracts.
Kidney stones and calcifications in soft tissues such as blood vessels, heart, lungs, and skin may form.
Cholestatic jaundice rarely develops.
Treatment
Overdose requires treatment of hypercalcemia. The drug should be discontinued. Depending on the degree of hypercalcemia, a low-calcium or calcium-free diet, plenty of fluids, forced diuresis induced by the administration of furosemide, and the administration of glucocorticoids and calcitonin are recommended.
With normal kidney function, the calcium level is significantly reduced by the introduction of an infusion solution of sodium chloride (3-6 liters over 24 hours) with the addition of furosemide, in some cases it is also necessary to use 15 mg/kg body weight/hour of sodium edetate, constantly monitoring the calcium level and ECG. In oligoanuria, on the contrary, hemodialysis is necessary. There is no specific antidote.
Side effects
Adverse reactions are usually not observed when used in recommended doses.
In case of individual hypersensitivity to the drug, which is rare, or as a result of using very high doses for a long period, hypervitaminosis D may occur.
From the cardiovascular system: arrhythmia, arterial hypertension.
Gastrointestinal tract: loss of appetite, nausea, vomiting, constipation, dry mouth, flatulence, abdominal pain, diarrhea, dyspepsia, pancreatitis.
From the nervous system: headache, drowsiness, mental disorders, depression.
From the urinary system: increased calcium levels in the blood and/or urine, urolithiasis and tissue calcification, uremia, polyuria.
Skin: hypersensitivity reactions, including urticaria, rash, itching.
Musculoskeletal system: myalgia, arthralgia, muscle weakness.
From the organs of vision: conjunctivitis, photosensitivity.
Metabolic: hypercholesterolemia, weight loss, polydipsia, increased sweating.
On the part of the hepatobiliary system: increased activity of aminotransferases.
On the part of the psyche: decreased libido.
There have also been reports of rhinorrhea, hyperthermia, and dry mouth.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C, out of the reach of children.
Shelf life - 2 years.
