Xavron solution for injection 1.5 mg/ml ampoule 20 ml No. 2




Xavron injection solution is indicated for:
Alleviation of neurological symptoms, manifestations of impairments in activities of daily living and functional disorders associated with acute ischemic stroke. Slowing the progression of functional disorders in patients with amyotrophic lateral sclerosis.Composition
Active ingredient: edaravone;
1 ml of 1.5 mg of edaravone;
Excipients: sodium metabisulfite (E 223), sodium chloride, sodium hydroxide, phosphoric acid, water for injections.
Contraindication
Severe renal failure.
Hypersensitivity to the components of the drug.
Method of application
Neurological symptoms associated with acute ischemic stroke, manifestations of impairment of daily activities, relief of various types of dysfunctions: 30 mg of edaravone (1 ampoule) twice a day, morning and evening, by infusion over 30 minutes. Before administration, the contents of the ampoule are dissolved in 100 ml of 0.9% sodium chloride. Therapy should be started within 24 hours after the onset of symptoms, the duration of treatment is at least 14 days.
Application features
Pregnant women
Not recommended for use.
Drivers
The drug is intended for use in a hospital setting.
Overdose
Cases of overdose have not been described.
Side effects
From the urinary system: acute renal failure, nephrotic syndrome. From the skin: rash, redness, edema, itching, erythema. From the digestive system: liver dysfunction, hepatic failure, fulminant hepatitis, jaundice. From the nervous system: insomnia, headache. From the cardiovascular system: increased blood pressure. From the blood: agranulocytosis, DIC syndrome, decreased red blood cell count, leukocytosis, leukopenia, decreased hematocrit, decreased hemoglobin, thrombocytosis, thrombocytopenia. From the respiratory system: acute lung injury syndrome, accompanied by pyrexia, cough, shortness of breath, chest X-ray abnormalities. From the gastrointestinal tract: nausea, vomiting. From the musculoskeletal system: rhabdomyolysis. On the part of the immune system: shock, anaphylactic shock (urticaria, decreased blood pressure, difficulty breathing, etc.).Interaction
When used simultaneously with antibiotics with a renal type of excretion (cefazolin sodium, cefotiam hydrochloride, piperacillin sodium, etc.), there is a possibility of increased renal dysfunction; in the case of combined use, careful observation should be carried out, regularly analyzing renal function.
Storage conditions
Store at a temperature not exceeding 25 °C in the original packaging.
Keep out of reach of children.
Shelf life - 2 years.
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